Category: 716362-10-6

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

Triethylamine (7.0 mL, 51 mmol) was added to a suspension of 6-chloro-4-methoxynicotinic acid (2.615 g, 13.94 mmol, Intermediate 132) in MeCN (93 mL). N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (3.74 g, 19.5 mmol), HOBt (2.64 g, 19.5 mmol), and N,O-dimethylhydroxylamine hydrochloride (2.05 g, 21.0 mmol) were added, and the resulting mixture was stirred at rt for 3 days. After this time, the mixture was concentrated, and the residue was dissolved in EtOAc and water. The layers were mixed and separated, and the aqueous layer was extracted five times with EtOAc. The organic layers were combined, dried with anhydrous MgSO4, filtered, and concentrated. The residue was purified by silica gel chromatography (0?20% EtOAc/hexanes) to provide the title compound.

The synthetic route of 716362-10-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Wolin, Ronald L.; Fourie, Anne M.; Xue, Xiaohua; (85 pag.)US2019/382350; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

Triethylamine (7.0 mL, 51 mmol) was added to a suspension of 6-chloro-4-methoxynicotinic acid (2.615 g, 13.94 mmol, Intermediate 132) in MeCN (93 mL). N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (3.74 g, 19.5 mmol), HOBt (2.64 g, 19.5 mmol), and N,O-dimethylhydroxylamine hydrochloride (2.05 g, 21.0 mmol) were added, and the resulting mixture was stirred at rt for 3 days. After this time, the mixture was concentrated, and the residue was dissolved in EtOAc and water. The layers were mixed and separated, and the aqueous layer was extracted five times with EtOAc. The organic layers were combined, dried with anhydrous MgSO4, filtered, and concentrated. The residue was purified by silica gel chromatography (0?20% EtOAc/hexanes) to provide the title compound.

The synthetic route of 716362-10-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Wolin, Ronald L.; Fourie, Anne M.; Xue, Xiaohua; (85 pag.)US2019/382350; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 716362-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 6-chloro-N,4-dimethoxy-N-methylnicotinamide (3) (0673) To a solution of 6-chloro-4-methoxynicotinic acid (1, 25.0 g, 133.6 mmol) in dichloromethane (300 mL), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (38.44 g, 200.5 mmol), 1-hydroxybenzotriazole (30.40 g, 200.4 mmol) and N,N-diisopropylethylamine (69.8 mL, 400.8 mmol) were added at 0 C. and stirred the mixture for 5 min. N, O-dimethylhydroxylamine hydrochloride (2, 19.56 g, 200.53 mmol) was then added at same temperature and the reaction was stirred for 16 h at room temperature. After completion, reaction mass was diluted with dichloromethane and washed with cold water. The organic layer was separated and dried over sodium sulphate, filtered and concentrated to give crude. The crude was re-crystallised in ethanol to afford 6-chloro-N,4-dimethoxy-N-methylnicotinamide (3) as white solid. Yield: 19.3 g, 62%; MS (ESI) m/z 231.17 [M+1]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; eFFECTOR Therapeutics, Inc.; ERNST, Justin T.; REICH, Siegfried H.; SPRENGELER, Paul A.; TRAN, Chinh Viet; PACKARD, Garrick Kenneth; XIANG, Alan X.; NILEWSKI, Christian; MICHELS, Theo; (478 pag.)US2017/145026; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 716362-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 6-chloro-N,4-dimethoxy-N-methylnicotinamide (3) (0673) To a solution of 6-chloro-4-methoxynicotinic acid (1, 25.0 g, 133.6 mmol) in dichloromethane (300 mL), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (38.44 g, 200.5 mmol), 1-hydroxybenzotriazole (30.40 g, 200.4 mmol) and N,N-diisopropylethylamine (69.8 mL, 400.8 mmol) were added at 0 C. and stirred the mixture for 5 min. N, O-dimethylhydroxylamine hydrochloride (2, 19.56 g, 200.53 mmol) was then added at same temperature and the reaction was stirred for 16 h at room temperature. After completion, reaction mass was diluted with dichloromethane and washed with cold water. The organic layer was separated and dried over sodium sulphate, filtered and concentrated to give crude. The crude was re-crystallised in ethanol to afford 6-chloro-N,4-dimethoxy-N-methylnicotinamide (3) as white solid. Yield: 19.3 g, 62%; MS (ESI) m/z 231.17 [M+1]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; eFFECTOR Therapeutics, Inc.; ERNST, Justin T.; REICH, Siegfried H.; SPRENGELER, Paul A.; TRAN, Chinh Viet; PACKARD, Garrick Kenneth; XIANG, Alan X.; NILEWSKI, Christian; MICHELS, Theo; (478 pag.)US2017/145026; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 716362-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 6-chloro-4-methoxynicotinic acid (12 g, 64 mmol) in 50C12 (60 ml) was refluxed for 4 hours. The resulting solution was concentrated under vacuum, and the residue was azeotroped with toluene (30 ml) to afford a yellow solid, which was added intotBuOH (50 ml) and stirred at room temperature overnight. The reaction mixture partitioned between aq.NaOH (200 ml, 5%) and DCM (100 mL), and the aq. phase was extracted with DCM (2 x 100 mL). The organic layers were washed with brine (100 mL), dried over Na2504 and concentrated to afford tert-butyl 6-chloro-4-methoxynicotinate as yellow solid. ?H NIVIR(CDC13, 400 IVIHz) 8.60 (s, 1H), 6.87 (s, 1H), 3.92 (s, 3H), 1.54 (s, 9H). LC/MS (m/z): 244(M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; UJJAINWALLA, Fez; TAN, John Qiang; DANG, Qun; SINZ, Christopher J.; WANG, Ming; CHEN, Yili; CAI, Jiaqiang; DU, Xiaoxing; (41 pag.)WO2016/54806; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 716362-10-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 6-chloro-4-methoxynicotinic acid (12 g, 64 mmol) in 50C12 (60 ml) was refluxed for 4 hours. The resulting solution was concentrated under vacuum, and the residue was azeotroped with toluene (30 ml) to afford a yellow solid, which was added intotBuOH (50 ml) and stirred at room temperature overnight. The reaction mixture partitioned between aq.NaOH (200 ml, 5%) and DCM (100 mL), and the aq. phase was extracted with DCM (2 x 100 mL). The organic layers were washed with brine (100 mL), dried over Na2504 and concentrated to afford tert-butyl 6-chloro-4-methoxynicotinate as yellow solid. ?H NIVIR(CDC13, 400 IVIHz) 8.60 (s, 1H), 6.87 (s, 1H), 3.92 (s, 3H), 1.54 (s, 9H). LC/MS (m/z): 244(M+H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; UJJAINWALLA, Fez; TAN, John Qiang; DANG, Qun; SINZ, Christopher J.; WANG, Ming; CHEN, Yili; CAI, Jiaqiang; DU, Xiaoxing; (41 pag.)WO2016/54806; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6ClNO3

Triethylamine (7.0 mL, 51 mmol) was added to a suspension of 6-chloro-4-methoxynicotinic acid (2.615 g, 13.94 mmol, Intermediate 66) in MeCN (93 mL). N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (3.74 g, 19.5 mmol), HOBt (2.64 g, 19.5 mmol), and N,O-dimethylhydroxylamine hydrochloride (2.05 g, 21.0 mmol) were added, and the resulting mixture was stirred at rt for 3 days. After this time, the mixture was concentrated, and the residue was dissolved in EtOAc and water. The layers were mixed and separated, and the aqueous layer was extracted five times with EtOAc. The organic layers were combined, dried with anhydrous MgSO4, filtered, and concentrated. The residue was purified by silica gel chromatography (0?20% EtOAc/hexanes) to provide the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; Janssen Pharmaceutica NV; Goldberg, Steven; Martin, Connor L.; Fennema, Elizabeth G.; Kummer, David A.; Nishimura, Rachel T.; Fourie, Anne M.; Xue, Xiaohua; (94 pag.)US2019/382373; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 716362-10-6

Intermediate 4.3 To a solution of Intermediate 4.4 (2.5 g, 2.63 mmol) in NMP (20 mL) is added K2CO3 (9.2 g, 66.6 mmol) and isobutyl iodide (2.3 mL, 20 mmol). The resulting mixture is stirred at 80 C. for 40 min. Then cyclopropylamine (4.6 mL, 66.6 mmol) is added and the reaction mixture is stirred overnight at 110 C. After adding water, the mixture is extracted with AcOEt. The organic layer is washed with water, brine and dried over MgSO4. Recrystallization from EtOAc-n-hexane gives Intermediate 4.3: colorless crystal, ES-MS: M+H=265: BtRet=1.54 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 716362-10-6, 6-Chloro-4-methoxynicotinic acid.

Reference:
Patent; Yokokawa, Fumiaki; Ehara, Takeru; Kawakami, Shimpei; Irie, Osamu; Suzuki, Masaki; Hitomi, Yuku; Toyao, Atsushi; US2008/319018; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A solution of 315 6-chloro-4-methoxynicotinic acid (9.0 g, 47.97 mmol, 1.0 eq) and 296 2,6-dichloroaniline (7.77 g, 47.97 mmol, 1.0 eq) in 24 toluene (270 mL) was purged with nitrogen for 10 min at rt, followed by addition of 91 PCl3 (45 mL). The resulting solution was stirred at 100 C. for 48 h. The progress of reaction was monitored by LCMS. The reaction mixture was concentrated, basified with saturated solution of 56 NaHCO3 (500 mL), extracted with EtOAc (2×100 mL). The combined organic layers were washed with water (50 mL), with brine (50 mL), dried over Na2SO4, concentrated and purified by combi-flash [Silica gel 100-200 mesh; elution 0-30 19 EtOAc in 20 hexane] to afford the desired compound, 318 6-chloro-N-(2,6-dichlorophenyl)-4-hydroxynicotinamide (3.5 g, 22.98%) as an off white solid. (0428) LCMS: 317[M+1]+

With the rapid development of chemical substances, we look forward to future research findings about 716362-10-6.

Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 716362-10-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 716362-10-6 as follows.

6-Chloro-4-methoxynicotinic acid (18) was prepared according to Ehara et al., ACS Med. Chem. Lett. 2014, 5, 787-792. To a suspension of this compound (3.87 g, 9.97 mmol) in oxalyl chloride (25 mL, 37 g, 291.5 mmol) was added DMF (0.8 mL) followed by anhydrous CH2C12(10 mL) and the reaction mixture was stirred 2 h at 60 C. Afterwards the reaction mixture was concentrated using the argon flow and the residue was dried under reduced pressure affording the respective chloroanhydride (4.0 g, 100% crude) which was immediately used for the next step.To a solution of this compound in hot EtOAc (100 mL) was added 2,3,5,6-tetrafluorophenol (2.92 g, 19.35 mmol; vigorous gas evolution was observed). Thereafter, the mixture was cooled to ambient temperature, Et3N (2.68 mL, 1.96 g, 19.35 mmol) was added dropwise and the resulting suspension was stirred for 1 h. Afterwards, the reaction mixture was washed with H20 (3 X20 mL), brine (2×20 mL), dried and concentrated under reduced pressure. The residue was taken up in CH2Cl2(70 mL), the suspension was filtered, the filter cake was washed with CH2Cl2(50 mL). The collected dichloromethane fraction was concentrated under reduced pressure. The residue was recrystallized from hexane affording 14 (2.6 g, 44%) as a colorless solid. The mother liquor was concentrated by reduced pressure and the residue was purified by column chromatography (CH2Cl2:hexane=8:2.5) giving the second crop of 14 (0.8 g, total 58%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,716362-10-6, its application will become more common.

Reference:
Patent; UNIVERSITAeT ZU KOeLN; NEUMAIER, Bernd; ZLATOPOLSKIY, Boris; KRAPF, Philipp; RICHARZ, Raphael; DRZEZGA, Alexander; (49 pag.)WO2019/175405; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem