Category: 716362-10-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 716362-10-6

Intermediate 4.3 To a solution of Intermediate 4.4 (2.5 g, 2.63 mmol) in NMP (20 mL) is added K2CO3 (9.2 g, 66.6 mmol) and isobutyl iodide (2.3 mL, 20 mmol). The resulting mixture is stirred at 80 C. for 40 min. Then cyclopropylamine (4.6 mL, 66.6 mmol) is added and the reaction mixture is stirred overnight at 110 C. After adding water, the mixture is extracted with AcOEt. The organic layer is washed with water, brine and dried over MgSO4. Recrystallization from EtOAc-n-hexane gives Intermediate 4.3: colorless crystal, ES-MS: M+H=265: BtRet=1.54 min.

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Reference:
Patent; Yokokawa, Fumiaki; Ehara, Takeru; Kawakami, Shimpei; Irie, Osamu; Suzuki, Masaki; Hitomi, Yuku; Toyao, Atsushi; US2008/319018; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

A solution of 315 6-chloro-4-methoxynicotinic acid (9.0 g, 47.97 mmol, 1.0 eq) and 296 2,6-dichloroaniline (7.77 g, 47.97 mmol, 1.0 eq) in 24 toluene (270 mL) was purged with nitrogen for 10 min at rt, followed by addition of 91 PCl3 (45 mL). The resulting solution was stirred at 100 C. for 48 h. The progress of reaction was monitored by LCMS. The reaction mixture was concentrated, basified with saturated solution of 56 NaHCO3 (500 mL), extracted with EtOAc (2×100 mL). The combined organic layers were washed with water (50 mL), with brine (50 mL), dried over Na2SO4, concentrated and purified by combi-flash [Silica gel 100-200 mesh; elution 0-30 19 EtOAc in 20 hexane] to afford the desired compound, 318 6-chloro-N-(2,6-dichlorophenyl)-4-hydroxynicotinamide (3.5 g, 22.98%) as an off white solid. (0428) LCMS: 317[M+1]+

With the rapid development of chemical substances, we look forward to future research findings about 716362-10-6.

Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 716362-10-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 716362-10-6 as follows.

6-Chloro-4-methoxynicotinic acid (18) was prepared according to Ehara et al., ACS Med. Chem. Lett. 2014, 5, 787-792. To a suspension of this compound (3.87 g, 9.97 mmol) in oxalyl chloride (25 mL, 37 g, 291.5 mmol) was added DMF (0.8 mL) followed by anhydrous CH2C12(10 mL) and the reaction mixture was stirred 2 h at 60 C. Afterwards the reaction mixture was concentrated using the argon flow and the residue was dried under reduced pressure affording the respective chloroanhydride (4.0 g, 100% crude) which was immediately used for the next step.To a solution of this compound in hot EtOAc (100 mL) was added 2,3,5,6-tetrafluorophenol (2.92 g, 19.35 mmol; vigorous gas evolution was observed). Thereafter, the mixture was cooled to ambient temperature, Et3N (2.68 mL, 1.96 g, 19.35 mmol) was added dropwise and the resulting suspension was stirred for 1 h. Afterwards, the reaction mixture was washed with H20 (3 X20 mL), brine (2×20 mL), dried and concentrated under reduced pressure. The residue was taken up in CH2Cl2(70 mL), the suspension was filtered, the filter cake was washed with CH2Cl2(50 mL). The collected dichloromethane fraction was concentrated under reduced pressure. The residue was recrystallized from hexane affording 14 (2.6 g, 44%) as a colorless solid. The mother liquor was concentrated by reduced pressure and the residue was purified by column chromatography (CH2Cl2:hexane=8:2.5) giving the second crop of 14 (0.8 g, total 58%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,716362-10-6, its application will become more common.

Reference:
Patent; UNIVERSITAeT ZU KOeLN; NEUMAIER, Bernd; ZLATOPOLSKIY, Boris; KRAPF, Philipp; RICHARZ, Raphael; DRZEZGA, Alexander; (49 pag.)WO2019/175405; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 716362-10-6, name is 6-Chloro-4-methoxynicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H6ClNO3

To a solution of the intermediate of step 3 (2.7 g, 14.4 mmol) in CH2Cl2 (75 mL) were added DIPEA (7.53 mL, 43.3 mmol) and HATU (5.49 g, 14.4 mmol) at 0 C. and RM was stirred for 15 min. O,N-Dimethyl-hydroxylamine hydrochloride (1.41 g, 14.4 mmol) was added at 0 C. and the RM was stirred at RT for 14 h. The RM was diluted with CH2Cl2 and was consecutively washed with water, sat. NaHCO3, sat. NH4Cl and brine. The organic layer was dried and the volatiles were removed under reduced pressure. The residue was purified by chromatography (SiO2, EtOAc/Hex) to yield the desired compound (3.1 g, 93%). [0353] LC-MS (Method 3): m/z [M+H]+=231.1 (MW calc.=230.65); Rt=2.61 min.

With the rapid development of chemical substances, we look forward to future research findings about 716362-10-6.

Reference:
Patent; GRUeNENTHAL GMBH; VOSS, FELIX; NORDHOFF, SONJA; WACHTEN, SEBASTIAN; WELBERS, ANDRE; RITTER, STEFANIE; US2015/166505; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem