Category: 71702-01-7

Related Products of 71702-01-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71702-01-7, name is 5-Bromo-6-chloronicotinonitrile, molecular formula is C6H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(a) Preparation of 3-bromo-2-chloro-5-formylpyridine 3-Bromo-2-chloro-5-cyanopyridine (8.6 g) in 90% formic acid (40 ml) and water (10 ml) were treated with Raney nickel/aluminum alloy (8.0 g) and the mixture stirred and heated to 55-60 for 6 hours. The mixture was left to stand for two days, and then filtered. The filtrate was diluted to 500 ml with water and extracted with ether (2*250 ml). The ether extract was washed with aqueous sodium carbonate, dried, and evaporated to give an oil. The oil was diluted with toluene which was then removed under reduced pressure. The residue was diluted with a little ether, the solution filtered, and the filtrate evaporated to give an oil identified as the required aldehyde.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 71702-01-7, 5-Bromo-6-chloronicotinonitrile.

Reference:
Patent; Imperial Chemical Industries Limited; US4317913; (1982); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 71702-01-7, name is 5-Bromo-6-chloronicotinonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C6H2BrClN2

Step 5; 3-Bromo-4- (3-bromo-5-cyano-pyridin-2-yloxy)-benzyl]- (3-methyl-butyl)-carbamic acid tert-butyl ester; Heat a mixture of the phenol obtained in step 4 (677 mg, 1.82 mmol), 5-Bromo-6-chloro- nicotinonitrile (395 mg, 1.82 mmol), K2CO3 (277 mg, 2.0 mmol) and DMF (22 mL) at 100C under N2 atmosphere overnight. Cool at room temperature. Pour into ice-water and extract with EtOAc. Dry the organic layer over Na2SO4. Eliminate the solvent. Purify by flash chromatography on silica gel (eluent : hexane/EtOAc 8/1) to afford the title compound (860 mg, 85%). H-NMR (CDCl3, 300 MHz): 8.30 (d, 1H, J= 2.0 Hz), 8.19 (d, 1H, J= 2.0 Hz), 7.53 (s, 1H), 7.29 (m, 1H), 7.18 (d, 1H, J= 8.3 Hz), 4.43 (m, 2H), 3.19 (m, 2H), 1.58-1. 42 (m, 12H), 0.90 (d, 6H, J= 6.5 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 71702-01-7, 5-Bromo-6-chloronicotinonitrile.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/90337; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem