Category: 71777-70-3

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71777-70-3, name is Ethyl 4-ethoxypicolinate, molecular formula is C10H13NO3, molecular weight is 195.22, as common compound, the synthetic route is as follows.HPLC of Formula: C10H13NO3

To a solution of ethyl 4-ethoxypicolinate (3.44 g, 17.43 mmol) and 4-methoxy acetophenone (2.62 g, 17.43 mmol) in THF (100 mL) and DMSO (50 mL) was added NaH (1.4 g, 34.80 mmol). The resulting mixture was stirred at 95 C. for 6 h. The reaction mixture was cooled to rt and quenched with water (100 mL). The mixture was extract with EtOAc (3×150 mL) and concentration to a yellow solid. The solid was washed with hexanes to afford the diketone (3.6 g, 69%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,71777-70-3, Ethyl 4-ethoxypicolinate, and friends who are interested can also refer to it.

Reference:
Patent; RVX Therapeutics Inc.; McLure, Kevin G.; Young, Peter R.; US2013/281396; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 71777-70-3, Ethyl 4-ethoxypicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 71777-70-3, blongs to pyridine-derivatives compound. Recommanded Product: 71777-70-3

Step-2: 4-Ethoxypicolinohydrazide: To a 0 C cooled solution of ethyl 4-ethoxypicolinate (5.0 g, 25.6 mmol) in ethanol (20 mL) was added hydrazine hydrate (6.0 g, 120 mmol) drop-wise. After stirring for 2 h at RT, the separated out solid was filtered. The solid residue was washed with water (50 mL) and dried to yield 5.80 g (99%) of the title compound as white solid HNMR (400 MHz, DMSO) delta 9.82 (brs, 1H, D20 exchangeable), 8.40 (d, = 5.5 Hz, 1Eta), 7.46 (d, = 2.5 Hz, 1Eta), 7.09(dd, = 5.5 &2.5HZ, 1Eta), 4.54 (brs, 2Eta, D20 exchangeable), 4.11(q, = 7.0Hz, 2Eta), 1.38 (t, = 7.0Hz,3H); GC-MS (m/z) 181(M)+.

The synthetic route of 71777-70-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUPIN LIMITED; IRLAPATI, Nageswara, Rao; SHAIKH, Zubair, Abdul Wajid; KARCHE, Vijay, Pandurang; DESHMUKH, Gokul, Keruji; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2013/164769; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 71777-70-3, Ethyl 4-ethoxypicolinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 71777-70-3, blongs to pyridine-derivatives compound. Recommanded Product: 71777-70-3

Step-2: 4-Ethoxypicolinohydrazide: To a 0 C cooled solution of ethyl 4-ethoxypicolinate (5.0 g, 25.6 mmol) in ethanol (20 mL) was added hydrazine hydrate (6.0 g, 120 mmol) drop-wise. After stirring for 2 h at RT, the separated out solid was filtered. The solid residue was washed with water (50 mL) and dried to yield 5.80 g (99%) of the title compound as white solid HNMR (400 MHz, DMSO) delta 9.82 (brs, 1H, D20 exchangeable), 8.40 (d, = 5.5 Hz, 1Eta), 7.46 (d, = 2.5 Hz, 1Eta), 7.09(dd, = 5.5 &2.5HZ, 1Eta), 4.54 (brs, 2Eta, D20 exchangeable), 4.11(q, = 7.0Hz, 2Eta), 1.38 (t, = 7.0Hz,3H); GC-MS (m/z) 181(M)+.

The synthetic route of 71777-70-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUPIN LIMITED; IRLAPATI, Nageswara, Rao; SHAIKH, Zubair, Abdul Wajid; KARCHE, Vijay, Pandurang; DESHMUKH, Gokul, Keruji; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2013/164769; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 71777-70-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.71777-70-3, name is Ethyl 4-ethoxypicolinate, molecular formula is C10H13NO3, molecular weight is 195.22, as common compound, the synthetic route is as follows.

To a solution of ethyl 4-ethoxypicolinate 198 (1 .6 g, 8.2 mmol) in concentrated H2SO4 (80 mL) was added NBS (2.7 g, 14.8 mmol). The reaction was stirred at room temperature overnight then quenched by addition of saturated aqueous NaHCCb (150 mL). The aqueous layer was extracted with DCM (3 x 130 mL) and the combined organic layers dried ( a2S04) and concentrated to give the title compound as a yellow solid (2.0 g, 91 %). 1H NMR (400 MHz, CDCI3) delta 8.67 (s, 1 H), 7.63 (s, 1 H), 4.94-4.40 (m, 2H), 4.29-4.23 (m, 2H), 1 .54-1 .51 (0853) (m, 3H), 1 .46-1 .42 (m, 3H); LCMS-C: RT 2.59 min; m/z 274.0, 276.0 [M+H]+

Statistics shows that 71777-70-3 is playing an increasingly important role. we look forward to future research findings about Ethyl 4-ethoxypicolinate.

Reference:
Patent; CTXT PTY LTD; BERGMAN, Ylva Elisabet; FOITZIK, Richard Charles; MORROW, Benjamin Joseph; CAMERINO, Michelle Ang; WALKER, Scott Raymond; LAGIAKOS, H. Rachel; FEUTRILL, John; STEVENSON, Graeme Irvine; STUPPLE, Paul Anthony; (222 pag.)WO2016/34673; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem