Category: 717843-48-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 717843-48-6, name is 3-Bromo-6-methylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H5BrN2

Example 176 (7bR,11aS)-N-(2-Cyano-6-methyl-3-pyridinyl)-1,2,7b,8,9,10,11,11a-octahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-6-amine, bis hydrochloride salt A solution of tert-butyl (7bR,11aS)-6-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate from Example 56, Part B (300 mg, 0.89 mmol), 2-cyano-3-bromo-6-methylpyridine (200 mg, 1.02 mmol) and cesium carbonate (565 mg, 1.73 mmol) in anhydrous toluene (10 mL) was stirred under an argon atmosphere in a sealable test tube. The mixture was degassed with argon. [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium (II), complex with dichloromethane (35 mg, 0.043 mmol) was added and the reaction was sealed and heated at 160 C. in a microwave oven for 3600 sec. The reaction mixture was cooled, filtered through a pad of silica gel and concentrated in vacuo. Purification of the residue by flash column chromatography (silica gel, 10-50% EtOAc/hexanes) provided tert-butyl (7bR,11aS)-6-(2-cyano-6-methyl-3-pyridinyl)-amino-1,2,7b,10,11,11a-hexahydro-4H-[1,4]oxazepino[6,5,4-hi]pyrido[4,3-b]indole-9(8H)-carboxylate.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 717843-48-6, 3-Bromo-6-methylpicolinonitrile.

Reference:
Patent; Robichaud, Albert J.; Fevig, John M.; Mitchell, Ian S.; Lee, Taekyu; Chen, Wenting; Cacciola, Joseph; US2004/186094; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 717843-48-6, name is 3-Bromo-6-methylpicolinonitrile, the common compound, a new synthetic route is introduced below. COA of Formula: C7H5BrN2

A solution of 2-(tetaut-butoxycarbonylamino)phenylboronic acid (1.0 eq.) and 3-bromo-6-methylpicolinonitrile (from step 2) (1.0 eq.) in toluene (0.44 M) was mixed with tetrakis(t?phenyl-phosphine)palladium (5 mol%) and 2N aqueous potassium carbonate solution (2.0 eq.). The reaction was heated to 1000C and stirred overnight. After cooling to ambient temperature, the reaction content was diluted with 2% methanol in dichloromethane and water. The two phases were separated, and the aqueous layer was extracted twice with 2% methanol in dichloromethane. The combined organic layers were washed with brine, dried over anhydrous MgSO4, and concentrated en vacuo. The crude product was purified by flash chromatography on a COMBIFLASH system (ISCO) using 0-70% ethyl acetate in hexane to give 3- methylbenzo[f][l,7]naphthyridin-5-amine as a yellow solid. 1H NMR (methanol d-4): delta 8.85 (d, IH), 8.38 (d, IH), 7.72 (d, IH), 7.53-7.61 (m, 2H), 7.34-7.38 (dd, IH), 2.76 (s, 3H). LRMS [M+H] = 210.1

The synthetic route of 717843-48-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IRM LLC; NOVARTIS AG.; WO2009/111337; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 717843-48-6, 3-Bromo-6-methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C7H5BrN2, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5BrN2

(3) the 2 – bromo -6 – methyl -2 – cyano pyridine (25g, 127mmol) dissolved in the 1L in concentrated hydrochloric acid (HCl), mixture in 110 C stirring reaction under the condition of 2 days; removing the solvent to obtain crude product; the obtained crude product is dissolved in water, and addingNaHCO3, then filtered; the filtrate is ethyl acetate extraction, Na2SO4drying and vacuum concentrated to get the crude product 3 – bromo -6 – methyl -2 – picolinic acid; two product adds up the yield of 69.3%, about 19g.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,717843-48-6, 3-Bromo-6-methylpicolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; Suzhou Jianxiong Vocational and Technical College; Gu, Zhun; Wang, Yang; Jin, Chen; (7 pag.)CN106045902; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 717843-48-6, name is 3-Bromo-6-methylpicolinonitrile. A new synthetic method of this compound is introduced below., Formula: C7H5BrN2

Under vacuum,Crystal water with a mass ratio of 40:60:8 g (36.1 mmol) of zinc chloride is heated to melt and remove water.Under nitrogen protection, 75 ml of 1,2-dichloroethane was added in sequence.Compound 3 is 3-bromo-6-methyl-2-cyanopyridine 5.5g(27.9mmol),13 g (77 mmol) of monomethyl malonate potassium salt and 1.8 ml (11.0 mmol) of diisopropylethylamine were stirred and refluxed for 16 hours.After the system was cooled to room temperature, 20 ml of 6N hydrochloric acid was added.Returning again for 1 hour, separating the organic phase,The aqueous phase was extracted 3 times with dichloromethane.The organic phases were combined and dried over anhydrous magnesium sulfate.Remove organic solvent, purify,The compound 4 is obtained as methyl 3-(3-bromo-6-methylpyridine)-3-carbonylpropanoate, the yield is 82%, 6.6 g;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 717843-48-6, 3-Bromo-6-methylpicolinonitrile.

Reference:
Patent; Chinese Academy Of Sciences Xinjiang Physics And Chemistry Technology Institute; A Jiaikebaier·aisa; A Budula·yusupu; Huang Guozheng; Zhao Jiangyu; (20 pag.)CN108164461; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem