Category: 72093-04-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72093-04-0, name is 3-Chloro-4-methylpyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 72093-04-0

To a solution of lithium diisopropylamide (6mL, 2M in THF, l2mmol) in 5mL THF at -70C was added under argon a solution of 3-chloro-4-methylpyridine (1 .28g, leq, 1 Ommol) in 5mL THF. The mixture was stirred for 5mm at -70C and then allowed to reach -3 0C. Thereafter the mixture was cooled down to – 70C and a solution of 1-chloro-3,3-dimethylbutan-2-one (2.7g. 2eq, 2Ommol) in 5mL THF was added. Then the mixture was allowed to reach ambient temperature and stirred for lh. Thereafter the mixture wascooled to 0C and saturated aqueous ammonium chloride solution was added. After extraction with ethyl acetate and evaporation of the solvent the cmde material was purified via column chromatography over silica gel (eluent cyclohexane ethyl acetate gradient). After evaporation of the solvent 2g (8 1%) of 4-[(2- tert-butyloxiran-2-yl)methyl]-3-chloropyridine were obtained as colourless oil.MS (ESI): 226.1 ([M+H]+)

The synthetic route of 72093-04-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; HOFFMANN, Sebastian; SUDAU, Alexander; DAHMEN, Peter; WACHENDORFF-NEUMANN, Ulrike; BERNIER, David; BRUNET, Stephane; LACHAISE, Helene; VIDAL, Jacky; GENIX, Pierre; COQUERON, Pierre-Yves; GEIST, Julie; VORS, Jean-Pierre; KENNEL, Philippe; MILLER, Ricarda; WO2014/167010; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 72093-04-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72093-04-0, name is 3-Chloro-4-methylpyridine, molecular formula is C6H6ClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

30 mol of the compound 3-chloro-4-methylpyridine was dissolved in an aqueous solution containing 1.2 times the molar amount of methylamine, and then 0.2 mol of cuprous chloride was added thereto, and then heated to 140-150 degrees, and the raw material disappeared. The heating was stopped, cooled to room temperature, and the reaction liquid was extracted with dichloromethane, and then the organic phase was concentrated to give product 4, and the reaction yield was 65%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 72093-04-0, 3-Chloro-4-methylpyridine.

Reference:
Patent; Gansu Haotian Pharmaceutical Co., Ltd.; Xue Jijun; Yang Bo; Li Xuehai; Wang Shijiao; Qi Tafamingrenqingqiubugongkaixingming; (12 pag.)CN108689915; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 72093-04-0, name is 3-Chloro-4-methylpyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 72093-04-0

To a solution of lithium diisopropylamide (6mL, 2M in THF, l2mmol) in 5mL THF at -70C was added under argon a solution of 3-chloro-4-methylpyridine (1 .28g, leq, 1 Ommol) in 5mL THF. The mixture was stirred for 5mm at -70C and then allowed to reach -3 0C. Thereafter the mixture was cooled down to – 70C and a solution of 1-chloro-3,3-dimethylbutan-2-one (2.7g. 2eq, 2Ommol) in 5mL THF was added. Then the mixture was allowed to reach ambient temperature and stirred for lh. Thereafter the mixture wascooled to 0C and saturated aqueous ammonium chloride solution was added. After extraction with ethyl acetate and evaporation of the solvent the cmde material was purified via column chromatography over silica gel (eluent cyclohexane ethyl acetate gradient). After evaporation of the solvent 2g (8 1%) of 4-[(2- tert-butyloxiran-2-yl)methyl]-3-chloropyridine were obtained as colourless oil.MS (ESI): 226.1 ([M+H]+)

The synthetic route of 72093-04-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; HOFFMANN, Sebastian; SUDAU, Alexander; DAHMEN, Peter; WACHENDORFF-NEUMANN, Ulrike; BERNIER, David; BRUNET, Stephane; LACHAISE, Helene; VIDAL, Jacky; GENIX, Pierre; COQUERON, Pierre-Yves; GEIST, Julie; VORS, Jean-Pierre; KENNEL, Philippe; MILLER, Ricarda; WO2014/167010; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 72093-04-0, name is 3-Chloro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C6H6ClN

To a mixture of 2-amino-N,N-dimethylbenzamide (1.3 g, 6.77 mmol), 3-chloro-4-methylpyridine (0.745 mL, 6.77 mmol), Palladium acetate (0.150 g) and BINAP (0.60 g) in 1,4-dioxane (10 mL) was added NaH (0.677 g, 16.93 mmol) and the resulting mixture was heated at 100 C. for 2 hours. The solvent was removed under reduced pressure. The residue obtained was taken into dichloromethane (50 mL) and filtered through celite. The filtrate was washed with water (50 mL), dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified using flash column chromatography (SiO2) to provide 0.450 g of the desired product as a dark oil.

With the rapid development of chemical substances, we look forward to future research findings about 72093-04-0.

Reference:
Patent; ArQule, Inc.; US2010/249108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 72093-04-0 , The common heterocyclic compound, 72093-04-0, name is 3-Chloro-4-methylpyridine, molecular formula is C6H6ClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 32 Compound CM A solution of diisopropylamine (1.23 mL)in dry tetrahydrofuran (15 mL) is stirred and cooled to -70 C. under a nitrogen atmosphere. To this is added a 2.5M solution of n-butyl lithium in hexanes (3.52 mL) at -70 C. The mixture is stirred for 30 minutes then a solution of 3-chloro-4-methylpyridine (1.02 g) in dry tetrahydrofuran (10 mL) is added. The mixture is stirred for a further 40 minutes. A solution of 3-cyclopentyloxy-4,N-dimethoxy-N-methylbenzamide (2.23 g) in dry tetrahydrofuran (10 mL) is added and the mixture stirred at -70 C. for 30 minutes, -40 C. for 30 minutes, 0 C. for 30 minutes, and room temperature for 1 hour. A mixture of ethanol and hydrochloric acid 19:1 (40 mL) is added and then the reaction mixture is partitioned between brine (40 mL) and diethyl ether (40 mL). The ethereal phase is dried over sodium sulfate and concentrated in vacuo to give a pale yellow solid (3.0 g). The solid is triturated with diethyl ether and then purified by flash chromatography (ethyl acetate eluent on a silica column) to give a solid (1.6 g). The solid is triturated with diethyl ether, collected and dried to afford 1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(3-chloropyrid-4-yl)ethanone (1.35 g) as a cream solid m.p. 124-125 C. ?Elemental analysis: C,66.2; H,5.89; N,4.12%; calculated for C19 H20 ClNO3: C,65.99; H,5.83;[N,4.05%.]

The synthetic route of 72093-04-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rhone-Poulenc Rorer Limited; US5679696; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem