These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-52-4, its application will become more common.
Electric Literature of 7250-52-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 7250-52-4 as follows.
Example 13: Synthesis of 3-aminomethyl-4-methylpyridine EPO 100106] A round bottom flask was charged with 0.45g (3.3OmM) of 4- methylnicotinamide (27). The flask was flushed with argon, and 5OmL of dry THF was added by syringe. The resulting solution was cooled to 0 dg C, and 2.5mL (4.96mM) of a 2M solution of borane-dimethylsulfde complex (in THF) was added. A bubbler was attached, and the solution was allowed to warm to RT overnight. The solution was quenched with MeOH, and dried and evaporated to give 0.38g (95%) of 3-aminomethyl- 4-methylpyridine (28).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7250-52-4, its application will become more common.
Reference:
Patent; PHARMACOPEIA DRUG DISCOVERY, INC.; WO2006/108103; (2006); A1;,
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