Category: 72509-76-3

Singh, Bharpoor published the artcileMouth dissolving tablets: an innovative deviation in drug delivery system, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is mouth dissolving tablet drug delivery system mental disability.

The main aim of novel drug delivery system is to develop a dosage form which is easy to administer, free from side effects, exhibit immediate release and offer enhanced bioavailability for better patient compliance. To achieve such results oral drug delivery system, preferably, tablets are the most widely accepted dosage forms which offer numerous advantages. Beside those advantages, Dysphagia is the most common disadvantage of conventional tablets which is associated with number of conditions like sudden exposure of allergies, mental disability, motion sickness, unconsciousness, unavailability of water etc. To get rid from these problems several innovative drug delivery systems have been developed like Mouth Dissolving Tablets (MDT′s) which dissolve in saliva within a few seconds, when put on tongue. These tablets can be administered anywhere and anytime, without the need of water and are thus quite suitable for children, elderly and mentally disabled patients.

Journal of Pharmaceutical Sciences and Research published new progress about AIDS (disease). 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Guillemoto, Q. published the artcileTransfer of trace organic compounds in an operational soil-aquifer treatment system assessed through an intrinsic tracer test and transport modelling, Related Products of pyridine-derivatives, the main research area is trace organic compound transport modeling soil aquifer treatment system; Degradation; Reactive transport model; Soil-aquifer treatment; Sorption; Trace Organic Compounds.

Soil Aquifer Treatment (SAT) can provide supplementary treatment of trace organic compounds (TrOCs) such as pharmaceutical and industrial compounds present in Secondary Treated Wastewater (STWW). Concern on presence of unregulated TrOCs in natural systems has raised recently as well as the interest in SAT systems for remediation. The present study quantifies, at the field scale over35 m of lateral groundwater flow, the effectiveness of the Agon-Coutainville SAT system (Manche, Normandy, France) for TrOCs removal by sorption and biodegradation through monitoring of seven TrOCs (oxazepam, carbamazepine, benzotriazole, tolyltriazole, caffeine, paracetamol, ibuprofen) and major inorganic compounds as intrinsic tracers in STWW and groundwater during a 34-day STWW infiltration experiment during operational use of the SAT. Cationic exchanges and mixing between groundwater and STWW during the experiment were highlighted by major ions and geochem. simulations. Due to the low thickness of the unsaturated zone, a 1D anal. solution of the advection-dispersion equation (ADE) was applied on chloride data. Chloride was used as conservative intrinsic tracer to calibrate the horizontal flow and transport parameters such as the aquifer dispersion coefficient (D) and the average pore water velocity (ν) allowing estimation of the groundwater residence time. Transport and attenuation of the TrOCs were simulated assuming first-order degradation constant (μ) and linear retardation coefficient (R), calibrated to simulate the observed temporal changes in the breakthrough of TrOCs. Sorption was found to play a role in the transport of TrOCs, notably for oxazepam with a higher linear retardation coefficient value of 2.2, whereas no significant differences of retardation were observed for carbamazepine, tolyltriazole, benzotriazole (1.37, 1.35, 1.36 resp.). Estimated first order degradation rate constants, between 0.03d-1 for carbamazepine and 0.09d-1 for tolyltriazole, were generally high compared to the literature, possibly due to favorable redox conditions and important microbial activities within the system. This study provides evidence of the efficiency of the Agon-Coutainville SAT system for the removal of TrOCs.

Science of the Total Environment published new progress about Biodegradation. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Related Products of pyridine-derivatives.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Liuxi published the artcileEvaluation of polysaccharide-based chiral stationary phases in modern SFC-MS/MS for enantioselective bioanalysis., Product Details of C18H19Cl2NO4, the main research area is polysaccharide chiral stationary phase supercritical fluid chromatog mass spectrometry; supercritical fluid chromatog tandem mass spectrometry polysaccharide; SFC–MS/MS; chiral bioanalysis; chiral stationary phase; enantiomer; enantioselective bioanalysis; supercritical fluid chromatography.

Aim: The applicability of polysaccharide-based chiral stationary phases in modern supercritical fluid chromatog. (SFC)-MS/MS for chiral bioanal. was evaluated. Materials & methods: Ten popular polysaccharide-based chiral stationary phases (CSPs) were tested using a set of 23 drugs against three cosolvents. The effect of temperature and backpressure on separation was examined Results: The recommended order of CSPs for screening was determined Methanol with 0.1% NH4OH is proven to be the first choice of cosolvent. Temperature of 40°C and backpressure of 10 or 15 MPa are recommended starting conditions. Phospholipid elution profiles on the polysaccharide-based CSPs were reported for the first time under SFC conditions. Conclusion: A simplified screening protocol with straightforward method optimization approaches was generated for SFC chiral assay development in a reasonable time frame with a high success rate.

Bioanalysis published new progress about Blood analysis. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Product Details of C18H19Cl2NO4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Agin, Fatma published the artcileElectroanalytical Methods for Determination of Calcium Channel Blockers, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is review serum calcium channel blocker differential pulse voltammetry.

Background: Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanal. methods are very powerful anal. methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clin. samples at extremely low concentrations (10-50 ng/mL). The purpose of this review is to gather electroanal. methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biol. media selected mainly from current articles. Methods: This review mainly includes recent determination studies of calcium channel blockers by electroanal. methods from pharmaceutical dosage forms and biol. samples. The studies of calcium channel blockers electroanal. determination in the literature were reviewed and interpreted. Results: There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs. Conclusion: Electroanal. methods especially voltammetric methods supply reproducible and reliable results for the anal. of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatog. methods.

Current Analytical Chemistry published new progress about Blood analysis. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Namera, Akira published the artcileHigh-throughput monospin extraction for quantification of cardiovascular drugs in serum coupled to high-performance liquid hromatography-mass spectrometry, Application In Synthesis of 72509-76-3, the main research area is serum pindolol carazolol high performance liquid chromatog mass spectrometry.

A novel method coupling spin column extraction with high-performance liquid chromatog.-mass spectrometry was developed for simultaneous extraction of β -blockers and calcium channel blockers from human serum. Sample loading, washing, and elution were accomplished via centrifugation of the column, in which mixed-mode monolithic silica bonded to a C18 reversed phase, and a cation-exchange phase was packed in a spin column. The serum sample (0.2 mL) pH was adjusted to 3 and the analytes adsorbed onto the column were eluted with 0.1 mL MeOH containing 2% NH3. The recov eries of the tested drugs were 76-108%. A linear curve was observed up to a concentration of 500 ng/mL of the target drugs in serum (r20 0.996). The intra-day relative standard deviations at three different concentrations were 0.6-9.6%. The limits of detection were 2 ng/mL. The proposed method was successfully applied to clin. and forensic cases.

Acta Chromatographica published new progress about Blood pressure. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application In Synthesis of 72509-76-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Takaoka, Ryota published the artcileModel-based meta-analysis of changes in circulatory system physiology in patients with chronic heart failure, SDS of cas: 72509-76-3, the main research area is meta analysis chronic heart failure circulatory system.

Meta-anal. of changes in circulatory system physiol. in patients with chronic heart failure. To characterize and compare various medicines for chronic heart failure (CHF), changes in circulatory physiol. parameter during pharmacotherapy were investigated by a model-based meta-anal. (MBMA) of circulatory physiol. The clin. data from 61 studies mostly in patients with heart failure with reduced ejection fraction (HFrEF), reporting changes in heart rate, blood pressure, or ventricular volumes after treatment with carvedilol, metoprolol, bisoprolol, bucindolol, enalapril, aliskiren, or felodipine, were analyzed. Seven cardiac and vasculature function indexes were estimated without invasive measurements using models based on appropriate assumptions, and their correlations with the mortality were assessed. Estimated myocardial oxygen consumption, a cardiac load index, correlated excellently with the mortality at 3, 6, and 12 mo after treatment initiation, and it explained differences in mortality across the different medications. The anal. based on the present models were reasonably consistent with the hypothesis that the treatment of HFrEF with various medications is due to effectively reducing the cardiac load. Assessment of circulatory physiol. parameters by using MBMA would be insightful for quant. understanding of CHF treatment.

CPT: Pharmacometrics & Systems Pharmacology published new progress about Blood pressure. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, SDS of cas: 72509-76-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Xuan published the artcileA chemometric strategy for accurately identifying illegal additive compounds in health foods by using ultra-high-performance liquid chromatography coupled to high resolution mass spectrometry, Safety of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is health food illegal additive compound UHPLC HRMS identification chemometrics.

The accurate identification of unknown illegal additive compounds in complex health foods continues to be a challenging task in routine anal., because massive false pos. results can be screened with ultra-high-performance liquid chromatog. coupled to high-resolution mass spectrometry-based untargeted techniques and must be manually filtered out. To address this problem, we developed a chemometric-based strategy, in which data anal. was first performed by using XCMS, MS-DIAL, Mzmine2, and AntDAS2, to select those that provided acceptable results to extract common features (CFs), which can be detected by all of the selected methods. Then, CFs whose contents were significantly higher in the suspected illegal additive group were screened. Isotopic, adduct, and neutral loss ions were marked based on the CFs by using a new adaptive ion annotation algorithm. Fragment ions originating from the same compound were identified by using a novel fragment ion identification algorithm. Finally, a resp. mass spectrum was constructed for each screened compound to benefit compound identification. The developed strategy was confirmed by using a complex Chinese health food, Goujiya tea. The features of all illegal additive compounds were precisely screened by the developed strategy, and massive false pos. features from the current data anal. method were greatly reduced. The constructed resp. mass spectra can benefit compound identification and avoid the risk of identifying ions from the same illegal compound as different compounds Moreover, unknown compounds that are contained in an illegal compound library can be screened.

Analytical Methods published new progress about Blood pressure. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Safety of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Perez-Baeza, Mireia published the artcileComparative modelling study on enantioresolution of structurally unrelated compounds with amylose-based chiral stationary phases in reversed phase liquid chromatography-mass spectrometry conditions, Computed Properties of 72509-76-3, the main research area is modeling enantioresoln amylose based chiral stationary phase; reversed phase liquid chromatog mass spectrometry; Amylose-based chiral stationary phases. Reversed phase liquid chromatography. Enantioresolution modelling and description. Discriminant partial least squares. Feature selection.

Polysaccharide-based chiral stationary phases (CSPs) are the most used chiral selectors in HPLC. These CSPs can be used in normal, polar organic and aqueous-organic mobile phases. However, normal and polar organic mobile phases are not adequate for chiral separation of polar compounds, for the anal. of aqueous samples and for MS detection. In these situations, reversed phase conditions, without the usual non-volatile additives incompatible with MS detection, are preferable. Moreover, in most of the reported chiral chromatog. methods, retention is too large for routine work. In this paper, the chiral separation of 53 structurally unrelated compounds is studied using three com. amylose-based CSPs -coated amylose tris(3,5-dimethylphenylcarbamate) (Am1), coated amylose tris(5-chloro-2-methylphenylcarbamate) (Am2), and immobilized amylose tris(3-chloro-5-methylphenylcarbamate) (Am3)-. Chiral separations are carried out using acetonitrile/ammonium bicarbonate (pH = 8.0) mixtures, reversed mobile phases compatible with MS detection. To provide realistic conditions for routine anal., maximum retention factors are set to 15. Retention and enantioresoln. behavior of compounds in those CSPs are compared. On the other hand, to compare and describe the resolution ability of these CSPs, 58 structural variables of the compounds are tested to model for the first time a categorical enantioresoln. (CRs) for Am1 and Am3 CSPs. Discriminant partial least squares, for one response categorical variable (DPLS1) is used for feature selection, modeling. The final DPLS1 models showed good descriptive ability.

Journal of Chromatography A published new progress about Carbonyl group. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Computed Properties of 72509-76-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ines Silva, Maria published the artcileSmall scale in vitro method to determine a potential bioequivalent equilibrium solubility range for fed human intestinal fluid, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is human intestinal fluid potential bioequivalent equilibrium solubility; BCS; DCS; aprepitant; bioavailability; bromocriptine; carvedilol; fed intestinal fluid; felodipine; fenofibrate; ibuprofen; indomethacin; itraconazole; phenytoin; probucol; solubility; tadalafil; valsartan; zafirlukast.

Intestinal drug solubility is a key parameter controlling oral absorption but varies both intra and inter individuals and between the fasted and fed states, with food intake known to alter the bioavailability of many compounds Intestinal solubility can be measured in vitro either using sampled fed human intestinal fluid (FeHIF) or simulated fed intestinal fluid (SIF) but neither approach is optimal. FeHIF is difficult to obtain and variable, while for fed SIF multiple recipes are available with no consensus on the ideal version. A recent study characterised FeHIF aspirates using a multidimensional approach and calculated nine simulated media recipes that covered over ninety percent of FeHIF compositional variability. In this study the equilibrium solubility of thirteen drugs have been measured using the nine simulated media recipes and compared to multiple previous design of experiment (DoE) studies, which have examined the impact of fed SIF media components on solubility The measured nine media solubility data set is only statistically equivalent to the large scale 92 media DoE in 4 out of 13 drug comparisons, but has improved equivalence against small scale DoEs (9 or 10 media) with 6 out of 9 or 10 out of 12 (9 and 10 media resp.) equivalent Selective removal of non-biorelevant compositions from the 92 media DoE improves statistical equivalence to 9 out of 13 comparisons. The results indicate that solubility equivalence is linked to media component concentrations and compositions, the nine media system is measuring a similar solubility space to previous systems, with a narrower solubility range than the 92 point DoE but equivalent to smaller DoE systems. Phenytoin and tadalafil display a narrow solubility range, a behavior consistent with previous studies in fed and fasted states and only revealed through the multiple media approach. Custom DoE anal. of the nine media results to determine the most statistically significant component influencing solubility does not detect significant components. Indicating that the approach has a low statistical resolution and is not appropriate if determination of media component significance is required. This study demonstrates that it is possible to assess the fed intestinal equilibrium solubility envelope using the nine media recipes obtained from a multi-dimensional anal. of fed HIF. The derivation of the nine media compositions coupled with the results in this study indicate that the solubility results are more likely to reflect the fed intestinal solubility envelope than previous DoE studies and highlight that the system is worthy of further investigation.

European Journal of Pharmaceutics and Biopharmaceutics published new progress about Bioavailability. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Alhalaweh, Amjad published the artcileMolecular drivers of crystallization kinetics for drugs in supersaturated aqueous solutions, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is drug crystallization kinetics supersaturated aqueous solution; crystallization; glass; in silico modeling; physicochemical properties; precipitation; supersaturation.

In this study, we explore mol. properties of importance in solution-mediated crystallization occurring in supersaturated aqueous drug solutions Furthermore, we contrast the identified mol. properties with those of importance for crystallization occurring in the solid state. A literature data set of 54 structurally diverse compounds, for which crystallization kinetics from supersaturated aqueous solutions and in melt-quenched solids were reported, was used to identify mol. drivers for crystallization kinetics observed in solution and contrast these to those observed for solids. The compounds were divided into fast, moderate, and slow crystallizers, and in silico classification was developed using a mol. K-nearest neighbor model. The topol. equivalent of Grav3 (related to mol. size and shape) was identified as the most important mol. descriptor for solution crystallization kinetics; the larger this descriptor, the slower the crystallization Two electrotopol. descriptors (the atom-type E-state index for -Caa groups and the sum of absolute values of pi Fukui(+) indexes on C) were found to sep. the moderate and slow crystallizers in the solution The larger these descriptors, the slower the crystallization With these 3 descriptors, the computational model correctly sorted the crystallization tendencies from solutions with an overall classification accuracy of 77% (test set).

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystallization. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Recommanded Product: 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem