With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72537-17-8, name is 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, molecular formula is C6H2ClF4N, molecular weight is 199.53, as common compound, the synthetic route is as follows.Quality Control of 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine
500mL glass bottle,48.6 g (0.243 mol) of 2-fluoro-3-chloro-5-trifluoromethylpyridine,Dichlorohexane 200g,40.4 g (0.247 mol) of 30% sodium cyanide,4 g (0.018 mol) of benzyltriethylammonium chloride,Warmed to 20 C,Timed reaction 10h,After the water treatment,After the oil phase is recovered from dichloroethane,100-110 C / 15 mmHg fractions were collected.46.7 g of a colorless liquid 2-cyano-3-chloro-5-trifluoromethylpyridine was obtained.The content of 2-cyano-3-chloro-5-trifluoromethylpyridine in the product was 99.6% (GC)The total yield of the two-step reaction is 90.1%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,72537-17-8, 3-Chloro-2-fluoro-5-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.
Reference:
Patent; Inner Mongolia Jiaruimi Fine Chemical Co., Ltd.; Dong Yongxia; Xiang Bin; Li Jun; (5 pag.)CN107286087; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem