Application of 72583-83-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72583-83-6, name is 1-Methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine, molecular formula is C7H8N4, molecular weight is 148.17, as common compound, the synthetic route is as follows.
In a vial, to a mixture of intermediate 5 (0.02 g, 0.07 mmol), 7-methoxy-4,5- dihydronaphtho[l,2-d]thiazol-2-amine (0.02 g, 0.07 mmol) was added BOP (0.030 g, 0.069 mmol), DMF (0.3 mL), and DIEA (0.060 ml, 0.35 mmol). After 72 h, the reaction mixture was filtered and subjected to reverse phase HPLC purification to afford Example 1 (4.4 mg, 9.9 %). NMR (500MHz, OMSO-d6) delta 8.34 – 8.04 (m, 2H), 7.85 – 7.81 (m, 1H), 7.80 – 7.73 (m, 1H), 7.58 (d, J=8.2 Hz, 1H), 7.42 – 7.29 (m, 2H), 7.27 – 7.12 (m, 2H), 6.91 – 6.79 (m, 2H), 3.83 (s, 2H), 3.33 (br s, 1H), 3.02 – 2.93 (m, 2H), 2.92 – 2.84 (m, 2H), 3.77 (s, 3H). LCMS m/z = 505.0 (M+H)+; HPLC purity > 96% with retention time 1.81 min. [method A]
The chemical industry reduces the impact on the environment during synthesis 72583-83-6, I believe this compound will play a more active role in future production and life.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; ORWAT, Michael J.; PINTO, Donald J. P.; (183 pag.)WO2019/14300; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem