Category: 72587-18-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72587-18-9, name is 2-Chloro-5-(trifluoromethyl)pyridin-3-amine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H4ClF3N2

The preparation of 3-amino-2,6-dichloro-5-trifluoromethyl-pyridine from 3-amino-2- chloro-5-trifluoromethyl-pyridine was as follows. A solution of 3-amino-2-chloro-5- trifluoromethyl-pyridine (5 g) (prepared as described in EP 178260, EP 272824) and N- chlorosuccinimide (3.7 g) in acetonitrile (125 ml) was stirred at ambient temperature for 16 hours. The reaction mixture was poured into water, extracted with ethyl acetate, dried over sodium sulfate and then concentrated in vacuo. Chromatography on silica gel (eluent: hexane / ethyl acetate 3:1) afforded 3-amino-2,6-dichloro-5-trifluoromethyl-pyridine (3.5 g): MS (ES+) 231 / 233 / 235 (MH+); IH NMR (400 MHz, CDCl3) 4.34 (s, 2H), 7.35 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 72587-18-9.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; WO2009/138219; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 72587-18-9 ,Some common heterocyclic compound, 72587-18-9, molecular formula is C6H4ClF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(4) 2.50 g of 6-chloro-3- (ethanesulfonyl) pyridine-2-carboxylic acid,And 30 mL of toluene were added 1.31 g of thionyl chloride,And one drop of DMF were heated under reflux for 3 hours.The reaction mixture was concentrated and dissolved in 30 mL of tetrahydrofuran, and under ice cooling,1.97 g of 3-amino-2-chloro-5- (trifluoromethyl) pyridine,And triethylamine (1.10 g) were added dropwise thereto.After stirring at room temperature for 3 hours,The reaction mixture was added to ice water and extracted with ethyl acetate.The obtained organic layer was washed with saturated brine,After drying over anhydrous magnesium sulfate, it was concentrated.The residue was subjected to silica gel column chromatography,2.4 g of Intermediate 36 described below was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72587-18-9, 2-Chloro-5-(trifluoromethyl)pyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sumitomo Chemical; Ikari, Kaori; (123 pag.)JP2019/6686; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem