Category: 72811-73-5

Synthetic Route of 72811-73-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 72811-73-5, name is 4-(m-Tolylamino)pyridine-3-sulfonamide. This compound has unique chemical properties. The synthetic route is as follows.

Example 12; Preparation of torsemide [1]; A mixture of 4-m-tolylamino-3-pyridinesulfonamide [2], yellow powder with 98.0 % purity (0.5 % of 4-chloro-3-pyridinesulfonamide [4]) by HPLC (5.0 g, 19 mmol), 1 N aqueous solution of sodium hydroxide (19 mL, 19 mmol) and phenyl isopropylcarbamate (5.1 g, 23 mmol) was stirred at 90-100 C for 5 hours diluted with water (20 mL), cooled to 20-25 C, extracted with ter-butyl methyl ether (4 x 30 mL), neutralized with an 1 N aqueous solution of sulfuric acid at 20-25 C and stirred for 1 hour at 60-70 C. The precipitated solids were filtered off, washed on filter with hot water (20 mL) and acetone (20 mL) to give 5.6 g (85 %) of crude torsemide [1] 99.4 % purity (0.1 % of 4-m-tolylamino-3-pyridinesulfonamide [2]) by HPLC. A solution of sodium hydroxide (0.62 g, 16 mmol) in water (15 g) was added to a stirred suspension of crude torsemide [1] (5.0 g, 14 mmol) in water (45 g) at 20-30 C. The mixture was stirred at 20-30 C until a complete dissolution of the solids (pH 12.9) and charcoal SA (0.5 g) was added to the solution. After stirring for 2 hours, the obtained mixture was filtered off, cooled to 15-20 C and acidified to pH 4.6 with a 1 N solution of sulfuric acid in water (-28 mL, 28 mmol) at the same temperature. The obtained suspension was stirred for about 2 hours at 15-20 C and filtered. The solid was washed on the filter with water (50 g) and dried under reduced pressure at 55 i 5 C (water bath) to a constant weight to give 4.7 g of torsemide [1] as a white solid with 99.4 % purity by HPLC.

According to the analysis of related databases, 72811-73-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FINETECH LABORATORIES LTD.; WO2003/97603; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, molecular formula is C12H13N3O2S, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Zhang, Na, once mentioned the new application about 72811-73-5, Product Details of 72811-73-5.

Synthesis, characterization, and ethylene oligomerization with star iminopyridine nickel(II) complexes

A series of star iminopyridine ligands, containing different groups (H, CH3, Br) in the pyridine ring, have been synthesized and characterized by FT-IR, H-1 NMR, and UV-vis. The corresponding nickel(II) complexes have been prepared in good yields. The nature of the Ni complexes has been established by FT-IR, UV-vis, ESI-MS, and ICP. Upon activation with methylaluminoxane (MAO), the nickel complexes were able to oligomerize ethylene to produce C-4-C-18 fractions at activity of up to 10(5) g (mol Ni h)(-1). The influence of substituent, catalyst structure, solvent, co-catalyst, and reaction conditions on the catalytic activity and product selectivity was investigated. The results showed that substitution on the pyridine ring had large influence on the catalytic activity and product selectivity. The catalytic activity increased at first and then decreased with the increase of reaction temperature and Al/Ni molar ratio. However, the catalytic activity continuously increased with increasing reaction pressure. When toluene was used as solvent and MAO was used as co-catalyst, catalytic activity of 4.39 x 10(5) g (mol Ni h)(-1) and 31.93% selectivity of higher carbon olefins (C-8-C-18) were obtained at 10 degrees C, Al/Ni molar ratio 500, and the reaction pressure 1.0 MPa.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 72811-73-5, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, SMILES is CC1=CC=CC(NC2=C(C=NC=C2)S(N)(=O)=O)=C1, belongs to pyridine-derivatives compound. In a article, author is Vidal, Alessio, introduce new discover of the category.

Stereoisomeric Control in [RuCl2(PTA)(2)(2L)] Complexes (2L=2py or bpy): From Theoretical Calculations to a 2+2 Metallacycle of Pyridylporphyrins

Treatment of the Ru(II) precursor cis,cis,trans-[RuCl2(dmso-S)(2)(PTA)(2)] (1, PTA=1,3,5-triaza-7-phosphaadamantane) with 2,2 ‘-bipyridine (bpy) in refluxing ethanol selectively affords cis,cis-[Ru(bpy)Cl-2(PTA)(2)] (2), whereas with pyridine (py), under the same conditions, it gives trans,cis,cis-[RuCl2(PTA)(2)(py)(2)] (6). The slightly less stable stereoisomer of 2, cis,trans-[Ru(bpy)Cl-2(PTA)(2)] (3), is obtained selectively through a different synthetic route. Isomers 2 and 3 are thermally stable, but cleanly equilibrate upon irradiation of an aqueous solution of either one with blue light. Intrigued by the stereoisomeric outcome in the preparations of this homogeneous set of complexes, we also investigated 2, 3, and 6 (and the mono-pyridine complex trans,mer-[RuCl2(py)(PTA)(3)] (7)) through a topological analysis of the electron density map using the quantum theory of atoms in molecules (QTAIM). The wealth of acquired experimental and calculated data allow us to discuss the stereochemical preferences of the [RuCl2(PTA)(2)(2 L)] complexes (2 L=bpy or 2py) in terms of electronic and steric contributions. The results of this speculative study on model complexes are transferable to similar systems. As an example, our findings from the reactivity of 1 towards pyridine allowed us to prepare the 2+2 pyridylporphyrin metallacycle trans,cis,cis-[RuCl2(PTA)(2)(4 ‘-cisDPyP)](2) (10, 4 ‘-cisDPyP=5,10-(4 ‘-pyridyl)-15,20-(phenyl)-porphyrin), whose X-ray molecular structure is also reported.

Reference of 72811-73-5, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 72811-73-5 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In an article, author is Esrafili, Leili, once mentioned the application of 72811-73-5, Computed Properties of C12H13N3O2S, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, molecular formula is C12H13N3O2S, molecular weight is 263.32, MDL number is MFCD00661332, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Selective detection and removal of mercury ions by dual-functionalized metal-organic frameworks: design-for-purpose

In this study, through introducing a new functional group into the structure, the performance and efficiency of MOFs as a sensor for heavy metal cations have been improved. It was observed that the N1,N3-di(pyridine-4-yl) malonamide ligand (-NH-CO-CH2-CO-NH-)(S), one of the pillar linkers, has not directly entered into the structure of the synthesized MOFs. To solve this issue, three new structures based on copper metal-organic frameworks and amide-functionalized pillar ligands (-NH-CO-), TMU-46, 47 and 48 have been synthesized under hydrothermal conditions. An exciting aspect of the acylamide pillar ligands is their efficient detection ability of Hg2+ (mercury ion) in the presence of other heavy metal cations such as Cd2+ (cadmium), Cu2+ (copper), and Cr3+ (chromium). Due to their chelating effect on heavy metal cations, we hypothesized that decoration of the MOF wall with both malonamide and acylamide struts would promote their Lewis basic properties, and improve the removal capacity of heavy metal ions. A new linker, containing suitable functional group malonamide (S) to enhance Hg2+ cation sensing, was successfully exchanged and the produced material was labeled TMU-46S, TMU-47S and TMU-48S. Designing dual-functionalized MOFs is our design-for-purpose approach for the decoration of MOF walls by suitable functional groups resulting in high removal capacity and sensitivity of heavy metal ions. To the best of our knowledge, this is the first report of a mixed amide-malonamide based MOF which provides a proper coordination site to coordinate strongly to Hg2+ ions, along with 714 mg g(-1) maximum adsorption capacity and 186 087 M-1Ksv. Generally, we attributed the impressive Hg2+ sensing of TMU-48S to synergistic effects of both hydrophilic chelating malonamide and acylamide functional groups. Hence, the results represent an effective strategy in designing and developing multi-functional MOF-based materials and their application in removal processes and environmental protection efforts.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, molecular formula is C12H13N3O2S. In an article, author is Sowmehesaraee, Mahsa Seifpanah,once mentioned of 72811-73-5, SDS of cas: 72811-73-5.

Fabrication of lead iodide perovskite solar cells by incorporating zirconium, indium and zinc metal-organic frameworks

The study aimed to investigate the role of the metal-organic frameworks in the perovskite solution, and their effects on perovskite crystal, absorption, film formation, and device performance. Three supramolecular compounds of Zirconium(IV), Indium(III) and Zinc(II) with proton transfer compound, obtained from 2,6-pyridine-dicarboxylic acid and 2,6-pyridinediamine, were synthesized, and characterized and used as additives in perovskite solar cells. The additives with different amounts were added to the CH3NH3PbI3 solutions to control the morphology of the perovskite layer during the film formation process. More importantly, the metal-organic frameworks serving as additives can help to form a better perovskite layer with fewer voids between CH3NH3PbI3 domains during phase transformation. The findings showed that using a 2 wt% of zinc metal-organic framework in the perovskite layer achieved yields results in the performance of perovskite solar cells. As a result, the current density (Jsc) of the new device increased from 7.02 to 9.36 mA/cm(2), and the Fill-Factor (FF) of the device improved from 0.42 to 0.62 for 2 wt% of zinc metal-organic framework. Also, the PCE (Efficiency) of perovskite solar cells achieved more than 90% of improvement after adding 2 wt% of zinc metal-organic framework as an additive in HTM-free conditions. FE-SEM and XRD studied the morphology of this new perovskite layer.

Interested yet? Keep reading other articles of 72811-73-5, you can contact me at any time and look forward to more communication. SDS of cas: 72811-73-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application of 72811-73-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, SMILES is CC1=CC=CC(NC2=C(C=NC=C2)S(N)(=O)=O)=C1, belongs to pyridine-derivatives compound. In a article, author is Opoku, Henry, introduce new discover of the category.

Random copolymerization of regiorandom polythiophene to improve planarity, aggregation and hole-transport

Charge transport in semiconducting conjugated polymers mainly devolves on the solid-state ordering of polymer chains with respect to its packing and orientation. Therefore, controlling the inter- and intra-molecular interactions of polymer chains is vital for achieving high performance conjugated polymers for electronic applications. Herein, by a macromolecular design scheme, we optimized the microstructure of a regiorandom poly (thiophene) copolymer for efficient charge transport. By introducing side chain-free phenyl and pyridyl units into the backbone, we achieved regiorandom polymers possessing improved inter- and intra-molecular interactions with a much closer pi-pi molecular stacking and a larger size of crystallites. Improved charge carrier motion and transport in both vertical and horizontal directions were revealed when the resulting phenyl and pyridyl substituted polymers were applied as hole-transporting materials in organic field-effect transistors, diode-like space-charge-limited current devices, and perovskite solar cells. Particularly, the pyridyl substituted polymer exhibited more than two times higher charge carrier mobilities in the above mentioned device configurations compared with the pristine regiorandom poly (thiophene).

Application of 72811-73-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 72811-73-5 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, SMILES is CC1=CC=CC(NC2=C(C=NC=C2)S(N)(=O)=O)=C1, in an article , author is Wzgarda-Raj, Kinga, once mentioned of 72811-73-5, Formula: C12H13N3O2S.

The role of sulfur interactions in crystal architecture: experimental and quantum theoretical studies on hydrogen, halogen, and chalcogen bonds in trithiocyanuric acid-pyridine N-oxide co-crystals

Four new multicomponent crystals of trithiocyanuric acid with pyridine N-oxide derivatives have been synthesized. Trithiocyanuric acid affects the solid state molecular architecture of all the co-crystals. Various patterns of its intermolecular interactions responsible for crystal packing, including hydrogen, halogen and chalcogen bonds, have been recognized. The most characteristic pattern is formed via N-H center dot center dot center dot S hydrogen bonds, linking trithiocyanuric acid molecules into R-2(2)(8) synthons, which are further joined into linear, zig-zag double chain, cyclic, or infinite 2D supramolecular patterns. Using experimental X-ray and theoretical DFT geometric properties, the energy and electron density distribution of various trithiocyanuric acid interactions have been analyzed and characterized. This allowed the classification of the observed N-H center dot center dot center dot S hydrogen bonds as strong ones. There is an electron donating interaction of the N-oxide group with the trithiocyanuric acid ring center observed in two crystal structures. As shown in this article, the trithiocyanuric acid ring possesses electron deficiency and Lewis acid character. Therefore, it may be an acceptor of stabilizing contacts with electron donors, among others, the N-oxide group, which is known as a relatively strong Lewis base.

Interested yet? Read on for other articles about 72811-73-5, you can contact me at any time and look forward to more communication. Formula: C12H13N3O2S.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, molecular formula is C12H13N3O2S, Computed Properties of C12H13N3O2S, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Dawar, Khadim, once mentioned the new application about 72811-73-5.

Effects of the nitrification inhibitor nitrapyrin and the plant growth regulator gibberellic acid on yield-scale nitrous oxide emission in maize fields under hot climatic conditions

Nitrification inhibitors are widely used in agriculture to mitigate nitrous oxide (N2O) emission and increase crop yield. However, no concrete information on their mitigation of N2O emission is available under soil and environmental conditions as in Pakistan. A field experiment was established using a silt clay loam soil from Peshawar, Pakistan, to study the effect of urea applied in combination with a nitrification inhibitor, nitrapyrin (2-chloro-6-tri-chloromethyl pyridine), and/or a plant growth regulator, gibberellic acid (GA(3)), on N2O emission and the nitrogen (N) uptake efficiency of maize. The experimental design was a randomized complete block with five treatments in four replicates: control with no N (CK), urea (200 kg N ha(-1)) alone, urea in combination with nitrapyrin (700 g ha(-1)), urea in combination with GA(3) (60 g ha(-1)), and urea in combination with nitrapyrin and GA(3). The N2O emission, yield, N response efficiency, and total N uptake were measured during the experimental period. The treatment with urea and nitrapyrin reduced total N2O emission by 39%-43% and decreased yield-scaled N2O emission by 47%-52%, relative to the treatment with urea alone. The maize plant biomass, grain yield, and total N uptake increased significantly by 23%, 17%, and 15%, respectively, in the treatment with urea and nitrapyrin, relative to the treatment with urea alone, which was possibly due to N saving, lower N loss, and increased N uptake in the form of ammonium; they were further enhanced in the treatment with urea, nitrapyrin, and GA(3) by 27%, 36%, and 25%, respectively, probably because of the stimulating effect of GA(3) on plant growth and development and the reduction in biotic and abiotic stresses. These results suggest that applying urea in combination with nitrapyrin and GA(3) has the potential to mitigate N2O emission, improve N response efficiency, and increase maize yield.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 72811-73-5 help many people in the next few years. Computed Properties of C12H13N3O2S.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Reference of 72811-73-5, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, SMILES is CC1=CC=CC(NC2=C(C=NC=C2)S(N)(=O)=O)=C1, belongs to pyridine-derivatives compound. In a article, author is Shiels, Oisin J., introduce new discover of the category.

Reactivity Trends in the Gas-Phase Addition of Acetylene to the N-Protonated Aryl Radical Cations of Pyridine, Aniline, and Benzonitrile

A key step in gas-phase polycyclic aromatic hydrocarbon (PAH) formation involves the addition of acetylene (or other alkyne) to a-type aromatic radicals, with successive additions yielding more complex PAHs. A similar process can happen for N-containing aromatics. In cold diffuse environments, such as the interstellar medium, rates of radical addition may be enhanced when the a-type radical is charged. This paper investigates the gas-phase ion-molecule reactions of acetylene with nine aromatic distonic sigma-type radical cations derived from pyridinium (Pyr), aniliniutn (Anl), and benzonitrilium (Bzn) ions. Three isomers are studied in each case (radical sites at the ortho, meta, and para positions). Using a room temperature ion trap, second-order rate coefficients, product branching ratios, and reaction efficiencies are measured. The rate coefficients increase from para to ortho positions. The second-order rate coefficients can be sorted into three groups: low, between 1 and 3 x 10 – molecule(-1) s(-1) (3Anl and 4Anl); intermediate, between 5 and 15 X 10(-12) cm(3) molecule(-1) s(-1) (2Bzn, 3Bzn, and 4Bzn); and high, between 8 and 31 X 10(-11) cm(3) molecule(-1) s(-1) (2Anl, 2Pyr, 3Pyr, and 4Pyr); and 2Anl is the only radical cation with a rate coefficient distinctly different from its isomers. Quantum chemical calculations, using M06-2X-D3(0)/6-31++G(2df,p) geometries and DSD-PBEP86-NL/aug-cc-pVQZ energies, are deployed to rationalize reactivity trends based on the stability of prereactive complexes. The G3X-K method guides the assignment of product ions following adduct formation. The rate coefficient trend can be rationalized by a simple model based on the prereactive complex forward barrier height.

Reference of 72811-73-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 72811-73-5.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 72811-73-5, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 72811-73-5, Name is 4-(m-Tolylamino)pyridine-3-sulfonamide, SMILES is CC1=CC=CC(NC2=C(C=NC=C2)S(N)(=O)=O)=C1, belongs to pyridine-derivatives compound. In a article, author is Sim, Jaeuk, introduce new discover of the category.

gamma-Functionalization of alpha,beta-Unsaturated Nitriles under Mild Conditions: Versatile Synthesis of 4-Aryl-2-Bromopyridines

The front cover picture, designed by Jaeuk Sim from the group of Heesoon Lee and Jae-Kyung Jung, illustrates the synthesis of 4-aryl-2-halopyridines via gamma-functionalization of alpha,beta-unsaturated nitriles. Our method features enamine formation at the gamma-position of vinylogous nitriles followed by cyclization to heteroaromatics. In commemoration of Christmas, this picture depicts the reagents gathered around the Christmas tree to create diverse heterocycles through the enamine intermediates. Details of this work can be found in the Update on pages xxxx-xxxx (J. Sim, M. Viji, J. Rhee, H. Jo, S. J. Cho, Y. Park, S.-Y. Seo, K.-Y. Jung, H. Lee, J.-K. Jung, Adv. Synth. Catal. 2019, 361, xxxx-xxxx; DOI: 10.1002/adsc.201901002).

Electric Literature of 72811-73-5, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 72811-73-5 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem