Synthetic Route of 72830-08-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-08-1, name is (3,4-Dimethoxypyridin-2-yl)methanol, molecular formula is C8H11NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Add 9.22 kg of toluene,Add at room temperature2-hydroxymethyl-3,4-dimethoxypyridine 1.5kg,Cool down to 3 C ~ 10 C,Add 1.63 kg of thionyl chloride within 1 to 2 hours at 3 to 10 C.After the addition, the mixture was stirred at 5 to 10 C for 1 hour.Increase the temperature to 35 C ~ 40 C within 1 hour,Incubate at 35-40 C for 4 hours.After TLC detection, the temperature control is 35-40 C.Vacuum distilling thionyl chloride for 3 to 4 hours, adding 9 kg of toluene, and cooling to 20 to 25 C.Centrifugal filtration, 0.64 L of toluene washed filter cake, drained,Drying at 50-55 C for 6-8 hours,2-Chloromethyl-3,4-dimethoxypyridine hydrochloride (III) was obtained.
According to the analysis of related databases, 72830-08-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chengdu Tiantaishan Pharmaceutical Co., Ltd.; Wang Jing; Jiang Wei; Xie Xiaofei; Zeng Yehao; Wang Wei; Gong Shiyu; Zhao Dongming; (29 pag.)CN109354587; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem