Category: 72830-09-2

Related Products of 72830-09-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride. A new synthetic method of this compound is introduced below.

Examples; Starting compounds and intermediates; 2-(3,4-Dimethoxy-pyridine-2-ylmethylsulfanyl)-5-methoxy-3H-imidazo[4,5-b]pyridine A reaction mixture of 10.00 g (55.20 mmol) 5-methoxy-3H-imidazo[4,5-b]pyridine-2-thiol and 12.37 g (55.20 mmol) 2-chloromethyl-3,4-dimethoxy pyridinium chloride in isopropanol (200 ml) is stirred for 2 h under reflux. The mixture is concentrated, filtered and dried at 60C for 16 h. Afterwards the crude hydrochloride of the product is suspended in a mixture of water dichloromethane and is basified to pH 8 by adding sodium hydroxide solution (6 N). The mixture is extracted with dichloromethane three times. The combined organic layers are washed with water, dried over calcium chloride, concentrated in vacuo, reslurried in acetone and dried again in vacuo to give 14.76 g (44.4 mmol / 80 %) of the title product with a melting point of 157.0C (acetone).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, and friends who are interested can also refer to it.

Reference:
Patent; ALTANA PHARMA AG; WO2005/105799; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 72830-09-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride. A new synthetic method of this compound is introduced below.

Examples; Starting compounds and intermediates; 2-(3,4-Dimethoxy-pyridine-2-ylmethylsulfanyl)-5-methoxy-3H-imidazo[4,5-b]pyridine A reaction mixture of 10.00 g (55.20 mmol) 5-methoxy-3H-imidazo[4,5-b]pyridine-2-thiol and 12.37 g (55.20 mmol) 2-chloromethyl-3,4-dimethoxy pyridinium chloride in isopropanol (200 ml) is stirred for 2 h under reflux. The mixture is concentrated, filtered and dried at 60C for 16 h. Afterwards the crude hydrochloride of the product is suspended in a mixture of water dichloromethane and is basified to pH 8 by adding sodium hydroxide solution (6 N). The mixture is extracted with dichloromethane three times. The combined organic layers are washed with water, dried over calcium chloride, concentrated in vacuo, reslurried in acetone and dried again in vacuo to give 14.76 g (44.4 mmol / 80 %) of the title product with a melting point of 157.0C (acetone).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, and friends who are interested can also refer to it.

Reference:
Patent; ALTANA PHARMA AG; WO2005/105799; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 72830-09-2, Adding some certain compound to certain chemical reactions, such as: 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride,molecular formula is C8H11Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72830-09-2.

Example 1 : Preparation of Pantoprazole Sodium2-Mercapto-5-difluoromethoxy benzimidazole (50 g) was added to an aqueous solution of sodium hydroxide (21.3 g in 350 mL de-ionized water) at room temperature to obtain a clear solution. An aqueous solution of 2-chloromethyl-3, 4-dimethoxypyridine hydrochloride (50 g in 150 mL water) was added to the above solution over a period of about 2.0-2.5 hours. The reaction mixture was stirred vigorously for about 2-2.5 hours. Progress of the reaction was monitored by thin-layer chromatography. The reaction mixture was extracted with dichloromethane and washed with water. Organic layer was concentrated. Methanol (50 mL) was added to the organic layer. The reaction mixture was cooled to -5 to -200C. Aqueous solution of sodium hydroxide (11.8 g in 50 mL water) was added followed by addition of sodium hypochlorite solution (431 mL) in an aqueous solution of sodium hydroxide (20 g/ 100 mL) over a period of about 30 to about 45 minutes. The progress of the reaction was monitored by thin-layer chromatography. After completion of the reaction, the reaction mixture was quenched with 5% sodium hydrogen sulphite solution (500 mL). Water (500 mL) was added. pH of the reaction mixture was adjusted to 9.0-10.5. Layers were separated and the aqueous layer was extracted with dichloromethane. The combined dichloromethane layers were concentrated completely to obtain a red-brown colored residue.The residue was dissolved in acetone (375 mL). The reaction mixture was cooled to 20-250C. Aqueous solution of sodium hydroxide (9.2 g in 25 mL water) was added followed by addition of a seed crystal of pantoprazole sodium. The reaction mixture was stirred, cooled, stirred, filtered and washed with cold acetone to obtain crude pantoprazole sodium as a wet cake.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2009/10937; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloromethyl-3,4-dimethoxypyridinium chloride

10% NaOH solution (42.5 gm in 425 ml of water) is added drop wise to a solution of 5-(difluoromethoxy)-2-mercapto benzimidazole (100.0 gm; 0.462 moles) in methanol(350.0 ml) at 10-150C. To the above solution a clear solution of 2-chloro-3, 4-dimethoxy pyridine hydrochloride (105.5 gm.0.473 moles in 525 ml of methanol) was added at 10-150C. The reaction mass was maintained at 10-15C for 30 minutes. The temperature of the reaction mass was slowly raised to 2O0C. The reaction mass was maintained at 20-25 C for 2 hours. Further the temperature was raised to 400C and maintained at 400C. Completion of the reaction is monitored by TLC. After completion of the reaction methanol is evaporated under reduced pressure to get a residue. Chilled water (600 ml) was added to the residue and the reaction mass was extracted with methylene chloride (600 ml, 300 ml x 2). The organic layers were separated and evaporated under reduced pressure to obtain a residue. Isopropyl alcohol (50 ml) and hexane (600 ml) were added to the reaction mass. The reaction mass was cooled to 0-50C and maintained at 0-5C for 30 minutes. The reaction mass was filtered at 0-5C and washed with chilled hexane (100 ml). The solids were dried under vacuum at 4O0C; Dry wt-162 gm (Yield=95.3%); HPLC Purity=99.21% w/w.; Melting range=l 15-1170C (Lit.7mp-H5-1 18C); MS (ESI); 368.0(M+H) +.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Patent; MACLEODS PHARMACEUTICALS LIMITED; WO2009/66317; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 72830-09-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, molecular weight is 224.08, as common compound, the synthetic route is as follows.

EXAMPLE I 5 Preparation of 5-Carbethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole 5-Carbethoxy-2-mercapto-1H-benzimidazole (2.0 g, 9 mmol) and NaOH (0.36 g, 9 mmol) in H2 O (1 ml) were dissolved in ethanol (30 ml). 3,4-dimethoxy-2-chloromethylpyridine hydrochloride (~6.6 mmol) as a crude material were added and the mixture was heated to boiling. NaOH (0.26 g, 6.6 mmol) in H2 O (1 ml) was added and the reflux was continued for 6 hours. The solvent was evaporated off and the residue was diluted with methylene chloride and water. The organic phase was dried over Na2 SO4 and the solvent removed under reduced pressure. Crystallizing from CH3 CN gave the desired product (1.75 g, 71%).

Statistics shows that 72830-09-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Patent; Aktiebolaget Astra; US5430042; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 72830-09-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, molecular weight is 224.08, as common compound, the synthetic route is as follows.

4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenol (100 mg, 0.454 mmol), 1-1 (85 mg, 0.454 mmol), and 2C03 (157 mg, 1.136 mmol) were combined in a 50-mL round bottom flask with a stirbar. DMF (3.03 mL) was added, and the reaction mixture was heated to 90 C for 4 h. The reaction mixture was diluted with EtOAc (30 mL), and washed sequentially with sat. aq. NaHC03 (30 mL) and brine (30 mL). The combined organics were dried over MgS0 , filtered, and concentrated in vacuo to afford the title compound as a tan solid (155 mg, 78%, >85% pure), which was used in the subsequent step without further purification.

Statistics shows that 72830-09-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BRESLIN, Michael, J.; COX, Christopher, D.; RAHEEM, Izzat, T.; WO2011/53559; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Product Details of 72830-09-2, 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, belongs to pyridine-derivatives compound. In a document, author is Geng, Tong, introduce the new discover.

Selectivity and capacity of the core-shell demetalizers for removal of nickel and calcium ions from heavy oil through conventional electric desalination process

In this work, micron core-shell particles (P4VP@SiO2) are synthesized by chemically grafting poly(4-vinyl pyridine) (P4VP) onto the surface of SiO2 to explore their adsorption selectivity and capacity over nickel and calcium ions from heavy oil through conventional electric desalination process. FT-IR, TGA, elemental analysis (EA), SEM and TEM are employed to confirm the structure and grafting ratio of P4VP@SiO2. Then, the effects of various process conditions on nickel and calcium removal rates are investigated. It is found that, removal rates of nickel and calcium increase with increasing demetalizer concentration. Proper temperature and oil/water ratio favor two metals removal rates. Interestingly, both the experimental results and DFT calculations show that three demetalizers exhibit different adsorption selectivity and capacity for the two metals. The order of adsorption selectivity for nickel is PVP@SiO2 > PVIm@SiO2 > P4VP@SiO2(strong to weak). Moreover, the absorption capacity follows the sequence: P4VP@SiO2 > PVP@SiO2 > PVIm@SiO2, and the calcium absorption capacity of P4VP@SiO2 is much higher than the other two. The removal rates reach 68.2% for nickel and 62.2% for calcium by P4VP@SiO2, indicating that it possesses a great potential for removal of both nickel and calcium from heavy oil.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 72830-09-2. Product Details of 72830-09-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, formurla is C8H11Cl2NO2. In a document, author is Aganda, Kim Christopher C., introducing its new discovery. Product Details of 72830-09-2.

Visible-light-mediated direct C3-arylation of 2H-indazoles enabled by an electron-donor-acceptor complex

A mild visible-light-mediated, photocatalyst-free arylation of 2H-indazoles was developed. The formation of an electron donor-acceptor complex by 2H-indazoles and aryl diazonium salts in the presence of pyridine allows the direct arylation of 2H-indazoles under visible-light irradiation. This process provides an efficient route for the synthesis of C3-arylated-2H-indazoles, which are important scaffolds of various bioactive compounds.

If you are hungry for even more, make sure to check my other article about 72830-09-2, Product Details of 72830-09-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Synthetic Route of 72830-09-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, SMILES is COC1=C(OC)C(CCl)=NC=C1.[H]Cl, belongs to pyridine-derivatives compound. In a article, author is Werth, Jacob, introduce new discover of the category.

Cobalt Catalyzed Reductive Spirocyclopropanation Reactions

Cobalt pyridine-diimine (PDI) complexes catalyze the reductive spirocyclopropanation of terminal 1,3-dienes. gem-Dichlorocycloalkanes serve as carbene precursors and Zn is used as a terminal electron source. The reaction is effective for a range of gem-dichloro partners including those containing sulfur and nitrogen heterocycles. An example of an intramolecular Rh-catalyzed [5+2]-cycloaddition of a vinyl spirocyclopropane is demonstrated, providing rapid access to a complex tricyclic framework. Overall, this catalyst system is capable of suppressing the kinetically facile 1,2-hydride shift, which has hampered the development of Simmons-Smith reactions using Zn carbenoids possessing beta-hydrogen atoms.

Synthetic Route of 72830-09-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 72830-09-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, SMILES is COC1=C(OC)C(CCl)=NC=C1.[H]Cl, belongs to pyridine-derivatives compound. In a document, author is Regeni, Irene, introduce the new discover, Name: 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Coal-Tar Dye-based Coordination Cages and Helicates

A strategy to implement four members of the classic coal-tar dye family, Michler’s ketone, methylene blue, rhodamine B, and crystal violet, into [Pd2L4] self-assemblies is introduced. Chromophores were incorporated into bis-monodentate ligands using piperazine linkers that allow to retain the auxochromic dialkyl amine functionalities required for intense colors deep in the visible spectrum. Upon palladium coordination, ligands with pyridine donors form lantern-shaped dinuclear cages while quinoline donors lead to strongly twisted [Pd2L4] helicates in solution. In one case, single crystal X-ray diffraction revealed rearrangement to a [Pd3L6] ring structure in the solid state. For nine examined derivatives, showing colors from yellow to deep violet, CD spectroscopy discloses different degrees of chiral induction by an enantiomerically pure guest. Ion mobility mass spectrometry allows to distinguish two binding modes. Self-assemblies based on this new ligand class promise application in chiroptical recognition, photo-redox catalysis and optical materials.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 72830-09-2 is helpful to your research. Name: 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem