Category: 72830-09-2

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, formurla is C8H11Cl2NO2. In a document, author is Nnabuike, Ginikachukwu G., introducing its new discovery. Product Details of 72830-09-2.

Copper(II) and Nickel(II) complexes of the non-steroidal anti-inflammatory drug indomethacin containing aromatic chelating N,N-donor ligand: Synthesis and structural studies

Two complexes [Cu(indo)(2)(phen)(H2O)];Cu-1 and [Ni(indo)(2)(phen)(H2O)(2)]center dot 1.5H(2)O;Ni-1, were synthesized by the reaction of their respective metal(II)acetates with indomethacin (indo) [1-(4chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid)] and a nitrogen donor heterocyclic ligand 1,10-phenanthroline (phen) in acetonitrile: water mixture (9:1 v/v), by refluxing at 80 degrees C for 3 h. The complexes were characterized by physicochemical, spectroscopic, and TG analysis. X-ray structural analysis showed that both complexes crystallizes in the triclinic space group P-1. Cu-1 consists of Cu(II) in square pyramidal geometry and coordinated to two monodentate indomethacin ligands, a bidentate 1,10phenanthroline, and one aqua ligand. Intermolecular O-H center dot center dot center dot O, C-H center dot center dot center dot O, C-H center dot center dot center dot Cl, Cl center dot center dot center dot Cl, and C-H center dot center dot center dot interactions in Cu-1 were responsible for the stability of the complex. Ni-1 is centrosymmetric and consists of Ni(II) in a distorted octahedral geometry, involving two trans monodentate indomethacin ligands, a bidentate 1,10-phenanthroline ligand, and two cis aqua ligands. There were two lattice water molecules outside the coordination sphere of Ni-1, that participated in extensive O-H center dot center dot center dot O interactions. The complex was further stabilized by C-H center dot center dot center dot O, C-H center dot center dot center dot pi, and pi…pi interactions. The monodentate coordination of the carboxylato oxygen of indomethacin ligand in the complexes was confirmed from the FTIR studies. TG analysis provided information on the stability and decomposition pattern of the complexes. (C) 2020 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 72830-09-2, Product Details of 72830-09-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Jiang, Xindong, once mentioned the new application about 72830-09-2, Safety of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Synthesis, properties and application of novel 5,6,5,6-tetracyclic pyrazine/pyrrole-fused unsymmetric bis(BF2) fluorescent dyes: BOPYPYs

Novel 5,6,5,6-tetracyclic pyrazine/pyrrole-fused unsymmetric bis(BF2) fluorescent dyes (BOPYPYs) were obtained by reaction of pyrrole-2-carboxaldehyde with 1-(pyrazin-2-yl)hydrazine in the presence of Et3N-BF3.Et2O for the first time. The absorption maxima of pyrazine-fused BOPYPY are obviously bathochromic shifts, in contrast to those of the reported BOPPY, indicating that the discrepant substitute groups between pyridine and pyrazine result in the remarkable wavelength difference. The new series of BOPYPYs possess high molar extinction coefficients, high fluorescence quantum yields, and larger Stokes shifts. A Knoevenagel reaction of BOPYPY with 4-dimethylaminobenzaldehyde smoothly produced the dye with the extension of pi-conjugation. Dimethylamino-containing BOPYPY as a pH-responsive fluorescent sensor could detect pH value. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 72830-09-2. The above is the message from the blog manager. Safety of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products, COA of Formula: C8H11Cl2NO2, 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, belongs to pyridine-derivatives compound. In a document, author is Subburu, Mahesh, introduce the new discover.

Effective photodegradation of organic pollutantsin the presence of mono and bi-metallic complexes under visible-light irradiation

The synthesis of new mono and bi-metallic complexes such as Zn (II) and Ag-Zn (II) complexes with organic functional group-based ligand (OFL) presented in the current work along with the exploration of their applicability in the photocatalytic degradation of organic dyes under visible-light irradiation. The Zn (II) complex obtained from organic functional group-based ligands, complexed with the donor atoms such as S and N under solvothermal conditions and Ag-Zn (II) complex formed through Ag ions complexed with pyridine ring nitrogen atom. These Zn(II)-complexes were systematically analyzed using the physicochemical studies and other spectroscopic techniques. From these facts, it is clarified that the complexes show square planar geometry with organic functional group-based ligands coordination via mercapto and azomethine groups. The reported complexes were used for the photodegradation of standard organic dye pollutants used in various textile and food processing industries. The complex [Ag-Zn(DCMPPT)(H2O)(OAc)] shows higher photocatalytic activity than [Zn (DCMPPT)(H2O)] because of the high surface area, low bandgap energy and further visible-light available for the initiation of (OH)-O-center dot radicals. To identify the active species in the photocatalytic process, the mechanism process also reported for the fast photodegradation of organic dye pollutants in the existence of some radical quenchers.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 72830-09-2. COA of Formula: C8H11Cl2NO2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Electric Literature of 72830-09-2, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, SMILES is COC1=C(OC)C(CCl)=NC=C1.[H]Cl, belongs to pyridine-derivatives compound. In a article, author is Huang, Yufei, introduce new discover of the category.

Catalytic Performance and Mechanism of Meso-Microporous Material beta-SBA-15-Supported FeZr Catalysts for CO2 Desorption in CO2-Loaded Aqueous Amine Solution

The huge energy consumption of rich amine solution regeneration severely restricts the large-scale application and promotion of the CO2 capture process by the amine method. In order to reduce the operating energy consumption during the CO2 capture process using amines, especially the energy consumption of absorbent regeneration, zeolite beta/SBA-15 (BS) has been synthesized in this work using the hydrothermal method with zeolite beta (beta) as the silicon source; beta was used to prepare the novel Zr@BS and Fe-Zr@BS catalysts for amine regeneration. Experiments for CO2 stripping were performed at 370.15 K using amine solvent [monoethanolamine (MEA)] with an initial CO2 loading of 0.50 mol CO2/mol amine. Additionally, all the materials were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, N-2 adsorption-desorption experiment, ammonia temperature-programmed desorption, and pyridine adsorption infrared spectroscopy. Also, the catalytic CO2 desorption performances of seven different catalysts (beta, SBA-15, three BS catalysts, Zr@BS, and Fe-Zr@BS) were investigated and assessed from the aspects of the cyclic capacity, desorption rate, and energy consumption. Experimental results indicated that the Fe-Zr@BS catalysts exhibited superior catalytic behaviors than other catalysts studied in this work, improving the desorption factor of MEA solution by 212% and bringing down the energy heat by 33% compared with 5 M MEA solution without catalysts. Furthermore, the Fe-Zr@BS catalysts show good stability and easy regeneration and do not influence absorption performance of the amine solution. Moreover, the possible catalytic mechanism for amine regeneration was proposed, and the stability of the material in terms of the structure of the material and the regeneration heat duty were also studied.

Electric Literature of 72830-09-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 72830-09-2 is helpful to your research.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Wang, Huibo, Product Details of 72830-09-2.

Carbon dots with positive surface charge from tartaric acid and m-aminophenol for selective killing of Gram-positive bacteria

Gram-positive bacteria are one of the most common pathogens causing severe and acute infection, and hospital infection caused by Gram-positive bacteria have increased significantly. Also, as antibiotics have been widely used, abusing of antibiotics is becoming an increasingly serious problem which is followed by dangerous drug resistance. Here, we developed a series of cationic carbon dots (CDs) with high-performance as antibacterial agents by using tartaric acid and m-aminophenol as precursors. The surface charge of these CDs can be regulated from +4.5 +/- 0.42 mV to +33.2 +/- 0.99 mV by increasing the contents of pyridine N and pyrrolic N in CDs. Further antibacterial experiments show that 250 mu g mL(-1) of CDs with +33.2 +/- 0.99 mV can selectively kill Gram-positive bacteria and the antibacterial efficiency can reach approximately >99%. These CDs with positive surface charge can be selectively absorbed on the cell walls of Staphylococcus aureus (S. aureus) via electrostatic interaction and then disturb their physiological metabolism, eventually leading to bacterial death. The present work provides a novel method to adjust the surface charge of CDs and apply these CDs as alternative antibacterial agents.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 72830-09-2, in my other articles. Product Details of 72830-09-2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Nichols, Asa W., Application In Synthesis of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reduction of dioxygen to water by a Co(N2O2) complex with a 2,2 ‘-bipyridine backbone

We report a Co-based complex for the reduction of O-2 to H2O utilizing decamethylferrocene as chemical reductant and acetic acid as a proton donor in methanol solution. Despite structural similarities to previously reported Co(N2O2) complexes capable of catalytic O-2 reduction, this system shows selectivity for the four-electron/four-proton reduction product, H2O, instead of the two-electron/two-proton reduction product, H2O2. Mechanistic studies show that the overall rate law is analogous to previous examples, suggesting that the key selectivity difference arises in part from increased favorability of protonation at the distal O position of the key intermediate Co(III)-hydroperoxide, instead of the proximal one. Interestingly, no product selectivity dependence is observed with respect to the presence of pyridine, which is proposed to bind trans to O-2 during catalysis.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 72830-09-2, in my other articles. Application In Synthesis of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 72830-09-2, Name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is , belongs to pyridine-derivatives compound. In a document, author is Li, Yong, Application In Synthesis of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Effects of ten vegetable oils on heterocyclic amine profiles in roasted beef patties using UPLC-MS/MS combined with principal component analysis

Soybean oil (SBO), rapeseed oil (RSO), peanut oil (PO), corn oil (CO), olive oil (OO), sunflower oil (SFO), rice germ oil (RGO), walnut oil (WO), torreya seed oil (TSO), and grapeseed oil (GSO) were used to investigate the formation of heterocyclic amines (HAs) in roasted beef patties. Seven HAs, including 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinolone (MeIQ), 2-amino-3methyl-3H-imidazo[4,5-f]quinoxaline (IQx), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-DiMeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 1-methyl-9H-pyrido[3,4-b]indole (harman), and 9Hpyrido[3,4-b]indole (norharman) were detected in control patties and patties with vegetable oils. GSO, SFO, and WO greatly reduced the content of PhIP and MeIQ. 1.25%TSO and 3.75% RGO showed higher inhibition effects on the more strongly mutagenic compounds (PhIP, MeIQ, IQx, 4,8-DiMeIQx, MeIQx). SBO, PO, and RSO promoted imidazoquin(ox)aline (MeIQ, MeIQx, 4,8-DiMeIQx, and IQx) and beta-carboline (harman and norharman); 1.25% SBO had the most significant promoting effect on total HA. This could be useful for the reduction of HA by selecting oils during cooking.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 72830-09-2, in my other articles. Application In Synthesis of 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Related Products of 72830-09-2 ,Some common heterocyclic compound, 72830-09-2, molecular formula is C8H11Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1: Preparation of Pantoprazole sodium compound of formula-la:Added a solution of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (50 grams in 250ml of water) to a solution of 49.8 grams of 5-difluoromethoxy 2-mercaptobenzimidazole, 500 ml water and sodium hydroxide (22.5 grams of flakes in 27.5 ml of water), slowly at 25-35C. Stirred the reaction mixture for 3 hours. Extracted the reaction mixture thrice with methylene chloride. Separated the organic and aqueous layer. Washed the organic layer with water. Cooled the organic layer to -5 to 0C. Added 550 grams of 3.1% sodium hypochlorite solution having pH 8.75 and assay 3.2 to the above reaction mixture at -5 to 0C. Stirred the reaction mixture for 3 hours at -5 to 0C. Quenched the reaction mixture with 56 grams of ammonium sulphate at below 10C. Stirred the reaction mixture for 30 minutes. Separated the organic and aqueous phases. Extracted the aqueous phase twice with methylene chloride. Washed the organic layer with water. Dried the organic phase over sodium sulphate. Distilled the solvent completely under reduced pressure at below 45C. Added 37.5 ml of acetone to the above crude and distilled the solvent completely under reduced pressure at below 45C. Dissolved the residue in 375 ml of acetone at 25-35C. Heated the reaction mixture to reflux temperature. Stirred the reaction mixture for 30 minutes at reflux temperature. Cooled the reaction mixture to 18-23C. Added aqueous sodium hydroxide solution (8.5 grams in 10 ml of water) at 18-23C. Stirred the reaction mixture for 1 hour at 18-23C. Cooled the reaction mixture to 0-5C. Stirred the reaction mixture for 3 hours. Filtered the solid and washed with acetone followed by washed with methylene chloride. The obtained solid is purified in acetone to get pure compound.The amount of sulfone compound of formula-6 and compound of formula- 1 present in the obtained solid was measured using HPLC and the results are as follows. Yield: 65 grams Example-3: Preparation of pantoprazole sodium sesquihydrate compound of formula-la:Added a solution of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (50 grams in 250ml of water) to a solution of 49.8 grams of 5-difluoromethoxy-2- mercaptobenzimidazole, 500 ml of water and aqueous sodium hydroxide (22.5 grams of flakes in 27.5ml of water), slowly at 25-350C. Stirred the reaction mixture for 3 hours. Extracted the reaction mixture thrice with methylene chloride. Separated the organic and aqueous layer. Washed the organic layer with water. Added 550 grams of 3.1% sodium hypochlorite having pH 8.75 and assay 3.2 to the above reaction mixture at 25-300C for 2 hours. Stirred the reaction mixture for 10 hours at 25-3O0C. Quenched the reaction mixture with water at 25-300C. Stirred the reaction mixture for 30 minutes at 25-300C. Separated the organic and aqueous phases. Extracted the aqueous layer with methylene chloride. Washed the organic phase twice with aqueous sodium hydroxide solution. Separated the phases. Cooled the aqueous layer to 10-150C. Adjusted the pH of the reaction mixture to 9.3 with aqueous acetic acid. Added 250 ml of methylene chloride. Stirred the reaction mixture for 15 minutes. Separated the organic phase. Extracted the reaction mixture with methylene chloride. Washed the organic layer with water. Distilled the solvent completely from organic layer at below 45C under reduced pressure. Added 37.5 ml of acetone to the crude and distilled the solvent completely under reduced pressure at below 45C. Dissolved the residue in 375 ml of acetone at 25-35C. Heated the reaction mixture to reflux temperature. Stirred the reaction mixture for 30 minutes at reflux temperature. Cooled the reaction mixture to 18-23C. Added aqueous sodium hydroxide solution (8.5 grams in 10 ml of water) at 18-23C. Stirred the reaction mixture for 1 hour at 18-23C. Cooled the reaction mixture to 0-50C and 35 ml of methylene chloride was added. Stirred the reaction mixture for 3 hours. Filtered the solid and washed with methylene chloride. The above obtained compound can optionally purified as follows.Acetone (400 ml) was added to the above obtained wet compound and heated to reflux. The obtained solution was treated with carbon and cooled the filtrate to 0-5C. Stirred for 2 hours. Filtered the precipitated solid and washed with 30 ml of chilled acetone followed by washing with 50 ml of methylene chloride. Methylene chloride (250 ml) was added to the obtained wet compound at 25-35C. Stirred the reaction mixture for 90 minutes at 25-350C. Filtered the precipitated solid and washed with 25 ml of methylene chloride. Dried the compound at 40-500C for 10 hours.Yield: 70 grams W.C : 5.9 %HPLC : 99.93 %; 0.02 % (Sulfone Impurity) PSD : before micronization : D (v, 0.1) is 0.4 mum ; D (v, 0.5) is 8.73 mum; D (v, 0.9) is 27.7 mum andD(4,3) is 12.02 mum.PSD : after micronization 😀 (v,0.1) is 1.75 mum; D (v,Q.5) is 4.92 mum; D (v,0.9) is 13.10 mum andD(4,3) is 6.35 mum.Exam…

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MSN LABORATORIES LIMITED; WO2008/1392; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 72830-09-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE I 4 Preparation of 5-chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (896 mg, 0.004 mol) was dissolved in 25 ml MeOH and treated with NaOH (390 mg, 0.008 mol) dissolved in 1.5 ml H2 O. 5-chloro-2-mercapto-1H-benzimidazole (812 mg, was added and the resulting mixture allowed to react for 2h at room temperature. The solvent was evaporated and the residue partitioned between 50 ml 2.5 % NaOH and 75 ml CH2 Cl2. The aqueous layer was separated and extracted twice with 25 ml CH2 Cl2. The organic layers were combined, washed with 25 ml H2 O, dried over MgSO and the solvent was evaporated. The crude product was triturated with approximately 5 ml of EtOAc saturated with NH3. The solid was collected and the mother liquor reprocessed furnishing 650 mg (48%) of the title compound as an off white powder. NMR data is given below.

According to the analysis of related databases, 72830-09-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AB Hassle; US4965269; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 72830-09-2

To the reaction flask was added 10 g of 2-chloromethyl-3,4-dimethoxypyridine hydrochloride(Compound 1), 10 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole(Compound 2), 100 ml of methylene chloride was added, and 130 g of a 10% sodium hydroxide solution was added dropwise, and the mixture was stirred at 20 to 30 C for 2 hours, Static separation, dichloromethane layer washed twice, each time with water 30ml,And then distilled under reduced pressure to give 16.6 g of a yellow oil (Intermediate 3);

The chemical industry reduces the impact on the environment during synthesis 72830-09-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Qilu Tianhe Huishi Pharmaceutical Co., Ltd.; Qin Chunxia; Li Baoyong; Wu Ke; Zhang Zhaozhen; Dong Tinghua; (6 pag.)CN105111187; (2017); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem