Category: 72830-09-2

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, molecular weight is 224.08, as common compound, the synthetic route is as follows.72830-09-2

1.5 equiv of 2-chloromethyl pyridine hydrochloride, 1.5 equiv of K2CO3 and 0.15 equiv of KI were added to a magnetically stirred solution of 1.0 equiv of 5 or 12 (2.0mmol) in a mixture of acetone (15 mL) and EtOH (15 mL). The reaction mixture was stirred constantly at 45 C for about 4 h. When the reaction was finished, as monitored by HPLC-MS, enough water (50 mL) was added. Then the reaction mixture was extracted with DCM (20 mL ¡Á 3). The organic phase was combined and concentrated under reduced pressure to give crude compound 6 or 13. For a typical compound of 6, for example, 2-[(3,4-dimethoxypyridin-2-yl)methylthio]-6-nitro-5-(piperidin-1-yl)-1H-benzimidazole, the orange powder was obtained in 91% yield, with an HPLC purity >98%.

Statistics shows that 72830-09-2 is playing an increasingly important role. we look forward to future research findings about 2-Chloromethyl-3,4-dimethoxypyridinium chloride.

Reference:
Article; Yan, Yu; Liu, Zijie; Zhang, Jianjun; Xu, Ruiming; Hu, Xiao; Liu, Gang; Bioorganic and Medicinal Chemistry Letters; vol. 21; 14; (2011); p. 4189 – 4192;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

72830-09-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example I 2 Preparation of 5-chloro-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazole 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (896 mg, 0.004 mol) was dissolved in 25 ml MeOH and treated with NaOH (390 mg, 0.008 mol) dissolved in 1.5 ml H2 O. 5-chloro-2-mercapto-1H-benzimidazole (812 mg, 0.0044 mol) was added and the resulting mixture allowed to react for 2h at room temperature. The solvent was evaporated and the residue partitioned between 50 ml 2.5 % NaOH and 75 ml CH2 Cl2. The aqueous layer was separated and extracted twice with 25 ml CH2 Cl2. The organic layers were combined, washed with 25 ml H2 O, dried over MgSO4 and the solvent was evaporated. The crude product was triturated with approximately 5 ml of EtOAc saturated with NH3. The solid was collected and the mother liquor reprocessed furnishing 650 mg (48%) of the title compound as an off white powder.

The chemical industry reduces the impact on the environment during synthesis 72830-09-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Aktiebolaget Hassle; US5019584; (1991); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The common heterocyclic compound, 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride, molecular formula is C8H11Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 72830-09-2

General procedure: 2-Chloromethyl pyridine hydrochloride (0.8 g, 5.0 mmol), 2-chloromethyl-4-methoxy-3-methylpyridine hydrochloride (1.0 g, 5.0 mmol), 2-chloromethyl-4-methoxy-3,5-dimethylpyridine hydrochloride (1.1 g, 5.0 mmol), 2-chloromethyl-3,4-dimethoxypyridine hydrochloride (1.12 g, 5.0 mmol), K2CO3 (1.1 g, 8.0 mmol) and KI (1.32 g, 8 mmol) were added to a magnetically stirred solution of 9 (1.24 g, 5.0 mmol) in a mixture of acetone (30 ml) and ethanol (30 ml). The reaction mixture was stirred constantly at 60 C for about 8 h. When the reaction was finished, as monitored by TLC, water (100 ml) was added. Then the reaction mixture was extracted with DCM (30 ml ¡Á 4). The organic phase was combined and concentrated under reduced pressure gave crude compounds 11a-d.

The synthetic route of 72830-09-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; El-Nezhawy, Ahmed O.H.; Biuomy, Ayman R.; Hassan, Fatma S.; Ismaiel, Ayman K.; Omar, Hany A.; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1661 – 1670;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem