Synthetic Route of 7340-22-9, Adding some certain compound to certain chemical reactions, such as: 7340-22-9, name is 3-(2-pyridyl)acrylicacid,molecular formula is C8H7NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7340-22-9.
General procedure: Add the acid (III) to the dried 10 mL round bottom flask and add the solvent to dichloromethane.Stirring was started, then 1.1 eq of oxalyl chloride was added to 0.1 eq of N,N-dimethylformamide, and the reaction was treated after 2 h.Concentration in vacuo gave the compound acid chloride (IV). Compound 2 was dissolved in DCM and 1.5 eq of triethylamine (TEA) was added.After stirring for 1-2 min, add 1.2 eq of acid chloride and stir at room temperature for 1 h.The reaction was completely detected by TLC, quenched with distilled water and extracted three times with DCM.The organic phase was combined, dried over anhydrous Na2SO4, filtered, and then evaporated.(Petroleum ether / ethyl acetate) gave the title compound 37-42 (white amorphous solid).
According to the analysis of related databases, 7340-22-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nankai University; Chinese Academy Of Medical Sciences Xueyebing Hospital (Xueyexue Institute); Tianjin Shang De Yaoyuan Technology Co., Ltd.; Zhang Quan; Chen Yue; Gao Yingdai; Ding Yahui; Li Ye; Lian Lihui; Ge Weizhi; (22 pag.)CN109206389; (2019); A;,
Pyridine – Wikipedia,
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