7356-60-7 | Pyridine-derivatives

10 Sep 2021 News Share a compound : 7356-60-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7356-60-7, Nicotinimidamide hydrochloride.

Synthetic Route of 7356-60-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7356-60-7, name is Nicotinimidamide hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

Compound F (9.15 g, 25 mmole),3-pyridinecarboxamidine hydrochloride (3.94g, 25mmole)And potassium hydroxide (1.68g, 30mmole) into a 500mL double-neck round bottom flask,Add 150 mL of ethanol and heat to reflux.After 3 hours of reaction,Leave to warm to room temperature, filter, wash the solid with ethanol,There was obtained 8.45 g of compound G as a white solid,The yield was 72.4%.

Reference:
Patent; E-RAY OPTOELECTRONICS TECHNOLOGY CO., LTD.; CHANGZHOU TRONLY E-RAY OPTOELECTRONICS MATERIAL CO., LTD.; HUANG, HEH LUNG; CHAO, TENG CHIH; GUO, HUANG MING; LIN, CHI JEN; CHANG, MIN JONG; (48 pag.)TWI672298; (2019); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The important role of 7356-60-7

The synthetic route of 7356-60-7 has been constantly updated, and we look forward to future research findings.

Electric Literature of 7356-60-7 , The common heterocyclic compound, 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Put compound A (10g, 23.03mmole) and 3,5-dibromobenzaldehyde (6.63g, 25.12mmole) in the reaction tank. After fully removing the water, add 150 ml of ethanol and start stirring. Then, sodium methoxide (0.33 g, 6.2 mmole) was added, and the mixture was stirred at room temperature for 16 hours. Thereafter, 3-Amidinopyridinium chloride (3.96 g, 25.13 mmole) and sodium hydroxide (1.6 g, 40.3 mmole) were added, and 30 ml of toluene was added thereto. The heating device was turned on and heated until 75 C and reacted overnight. After the reaction was completed, the solid was collected by filtration, heated and stirred with 250 ml of toluene, and the solid was filtered to obtain a milky white compound G (about 4.7 g).

The synthetic route of 7356-60-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yulei Optoelectric Technology Co., Ltd.; Huang Helong; Zhao Dengzhi; Xu Bowei; Lai Zhenchang; Yin Lijia; Zhang Minzhong; (32 pag.)CN110746412; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 7356-60-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7356-60-7, Nicotinimidamide hydrochloride.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7356-60-7, name is Nicotinimidamide hydrochloride. A new synthetic method of this compound is introduced below., Application In Synthesis of Nicotinimidamide hydrochloride

EXAMPLE 5 Synthesis of 4-(3-chlorophenyl)-N-(3,3-diphenylpropyl)-6-methyl-2-(pyridine-3-yl)-5-pyrimidinecarboxamide: The title compound was obtained by using 167 mg (0.400 mmol) of 2-acetyl-3-(3-chlorophenyl)-N-(3,3-diphenylpropyl) acrylamide, 94.5 mg (0.599 mmol) of 3-amidinopyridinium hydrochloride and 49.1 mg (0.599 mmol) of sodium acetate, in the same manner as that of Example 1. Yield: 72.0 mg (0.138 mmol) (35%) MS (ESI, m/z) 519 (M+H)+ 1H-NMR (CDCl3): 2.20 (2H, q), 2.68 (3H, s), 3.32 (2H, q), 3.79 (1H, t), 7.13-7.40 (13H, m), 7.76 (1H, dt), 7.83 (1H, t), 8.45 (1H, dd), 8.63 (1H, dt), 9.25 (1H, d).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7356-60-7, Nicotinimidamide hydrochloride.

Reference:
Patent; AJINOMOTO CO., INC.; US2004/9991; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 7356-60-7

Electric Literature of 7356-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-(3,5-Dibromophenyl)-1-(4-pyridin-3-ylphenyl)-acetone 3-(3,5-Dibromo-phenyl)-1-(4-pyridin-3- Yl-phenyl)-propanone (34 g, 76.73 mmole), 3-Amidinopyridinium chloride (18.02 g, 11.43 mmole),Potassium phosphate (57g, 268.56mmole),And 340 ml of xylene was placed in a reaction flask and heated to maintain a reflux of 140 C.After the reaction is completed, the temperature is lowered to 90 C.After adding 100 ml of deionized water and stirring for 5 minutes, the water layer was removed.After concentrating the organic layer until the solid precipitates,The solid was washed with ethyl acetate and filtered to give a white solid.After drying, 22 g of white solid 4-(3,5-dibromophenyl)-2-pyridin-3-yl-6-(4-pyridin-3-ylphenyl)-pyrimidine (4-(3, 5-Dibromo-phenyl)-2-pyridin-3-yl-6-(4-pyridin-3-yl-phenyl)-pyrimidine),The yield was 52.69%.

Reference:
Patent; E-ray Optoelectronics Technology Co Ltd; Huang, Heh Lung; Guo, Huang Ming; Chao, Teng Chih; Lin, Chi Jen; Chang, Min Jong; (53 pag.)TW2019/30287; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 7356-60-7

Brief introduction of Nicotinimidamide hydrochloride

Electric Literature of 7356-60-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7356-60-7, name is Nicotinimidamide hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

Compound B (124 g, 223.23 mmol),3-pyridinecarboxamidine hydrochloride (52.77g, 334.83mmol)With potassium phosphate (165.84g, 781.31mmol),1240 ml of xylene was placed in a reaction flask and heated with stirring to maintain reflux at 140 C.After the reaction was completed, the temperature was lowered to 90 C.Add 500ml of deionized water and stir for 5min.After removing the aqueous layer, the organic layer was concentrated to dryness and a solid precipitated out.The solid was washed with ethyl acetate and filtered to obtain a white solid.64g of white solid compound C was obtained after drying,Yield: 43.66%.

Extracurricular laboratory: Synthetic route of 7356-60-7

Reference of 7356-60-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7356-60-7, name is Nicotinimidamide hydrochloride, molecular formula is C6H8ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 3: To a solution of nicotinamidine hydrochloride (1 g, 6.35 mmol) in anhydrous DMF (12 mL) is added sodium salt of 2-dimethoxymethyl-3-hydroxy-acrylicacid methyl ester (1.46 g, 7.36 mmol) and the reaction mixture is heated at 1000C under N2 for 3 hours. After this time the reaction is cooled to room temperature and water (48 mL) is added. The precipitate is collected by filtration, washed with water and vacuum dried to afford 2-pyridin-3-yl- pyrimidine-5-carboxylic acid methyl ester (0.7 g, 51%). MS: 216 (M+H).

Reference:
Patent; SANOFI-AVENTIS; WO2008/121670; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem