Category: 73870-24-3

Application of 73870-24-3 ,Some common heterocyclic compound, 73870-24-3, molecular formula is C6H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Cytosine-pyridine (2) was obtained by mixing cytosine (0.65 g,5.93 mmol, 3 eq) and KI (10 mg, catalytic amount) in 10 mL of dry DMF. After degassing the suspension with argon for 15 min, NaH(0.118 g, 4.9 mmol, 2.5 eq) was added and the mixture was stirredfor 30 min. A solution of 4-(bromomethyl)pyridine hydrobromide(0.5 g, 1.97 mmol, 1 eq) in 4 mL of dry DMF was slowly added to themixture. The mixture was stirred at 40C overnight and the reac-tion progress was followed by TLC. The crude was dried undervacuum and then washed with a minimum amount of water. Theproduct was puried by column chromatography (silica gel, MeOH:Et3N: DCM 1:0.2:20) affording compound 2 (120 mg, 30%) as awhite powder; dH (500 MHz, DMSO-d6) 4.87 (2H, s, Ha), 5.73 (1H, d,3J 7.2 Hz, Hb), 7.08 (1H, s, brd, NH), 7.17 (2H, d,3J 6.0 Hz, Hm),7.21 (1H, s, brd, NH), 7.69 (1H, d,3J 7.2 Hz, Hc), 8.50 (2H, d,3J 6.0 Hz, Ho); dC (126 MHz, DMSO-d6) 50.6 (Ca), 93.9 (Cb), 122.0(Cm), 146.1 (Cc), 147.0 (Cp), 149.7 (Co), 155.7 (Cd), 166.1 (Ce); HRMS(ESI): MH, found 203.0934. C10H10N4O requires 203.0927; IR(cm1): 3337.24, 3115.39, 1652.03, 1597.71, 1486.09, 1423.17,1384.39, 1369.72, 1278.91, 1208.06, 1130.29, 965.29, 815.97, 781.56,704.43, 682.80, 567.57, 521.43, 474.65, 405.44.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73870-24-3, its application will become more common.

Reference:
Article; Bulach, Veronique; Hosseini, Mir Wais; Jouaiti, Abdelaziz; Kyritsakas, Nathalie; Tufenkjian, Elsa; Tetrahedron; vol. 76; 9; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 73870-24-3 ,Some common heterocyclic compound, 73870-24-3, molecular formula is C6H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3 To a suspension of NaH (170 mg of a 60% dispersion in mineral oil, 4.25 mmol) in anhydrous DMF (20 ml) is added 2,2,2-trifluoro-N-{4-[(2,2,2-trifluoro-acetylamino)-methyl]-piperidin-4-yl}-acetamide hydrochloride) (500 mg, 1.4 mmol) followed by 4-bromomethylpyridine hydrobromide (350 mg, 1.4 mmol). The reaction mixture is stirred at room temperature for 3 hours. The reaction mixture is quenched with sat. NH4Cl solution and is concentrated in vacuo. The residue is purified by column chromatography (basic alumina, MeOH/DCM) to obtain 2,2,2-Trifluoro-N-[1-pyridin-4-ylmethyl-4-(2,2,2-trifluoro-acetylamino)-piperidin-4-ylmethyl]-acetamide as off-white solid; [M+H]+ 413.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Vertex Pharmaceuticals Incorported; US2011/98311; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 73870-24-3 ,Some common heterocyclic compound, 73870-24-3, molecular formula is C6H7Br2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Compounds 20-26 (1 equiv.) were dissolved in DMF followed by the addition of potassium carbonate (1 – 3 equiv.) and the corresponding benzyl- or pyridinylderivate (1-2 equiv.). This mixture was allowed to stir at various temperatures and timespans, all of which are further specified at the corresponding compounds reported below. The crude product was then purified by either normal phase or reversed phase flash chromatography to yield compounds 30-36 and 40-46. The exact conditions of these purifications are reported below for each compound individually.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,73870-24-3, its application will become more common.

Reference:
Patent; VIB VZW; UNIVERSITEIT ANTWERPEN; UNIVERSITEIT GENT; VANDENABEELE, Peter; VANDEN BERGHE, Tom; AUGUSTYNS, Koen; HOFMANS, Sam; VAN DER VEKEN, Pieter; DEVISSCHER, Lars; (66 pag.)WO2019/154795; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 73870-24-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.73870-24-3, name is 4-(Bromomethyl)pyridine hydrobromide, molecular formula is C6H7Br2N, molecular weight is 252.93, as common compound, the synthetic route is as follows.

[00385] To a mixture of 53-1 (60 mg, 0.187 mmol, 1.00 eq) and 53-2 (85 mg, 0.336 mmol, 1.80 eq, HBr) in DMF (3 mL) was added K2C03 (100 mg, 0.723 mmol, 3.87 eq) in one portion at 25C. The mixture was stirred at 80 C for 3.5 h. LCMS showed the starting material was consumed completely and one main peak with the desired MS was detected. TLC showed one new spot was formed. The reaction mixture was extracted with EtOAc (40 mL) and washed with brine (30 mL*4). The organic layer was dried with anhydrous Na2S04, filtered, and concentrated under vacuum. The residue was purified by flash silica gel chromatography and then by prep-HPLC (basic condition) to provide the title compound (11.77 mg, 28.5 umol, 15.3% yield). LCMS (ESI): RT = 1.120 min, mass calc. for C20Hi5F3N6O 412.13, m/z found 413.0[M+H]+. 1HNMR (400MHz, DMSO-i_) 58.65- 8.55 (m, 3H), 8.01 (d, J=8.00 Hz, 1H), 7.47 – 7.37 (m, 2H), 7.33 (br d, J=5.20 Hz, 2H), 7.30 – 7.24 (m, 2H), 7.23- 7.17 (m, 2H), 7.06 (t, J=6.80 Hz, 1H), 6.12 (s, 2H).

Statistics shows that 73870-24-3 is playing an increasingly important role. we look forward to future research findings about 4-(Bromomethyl)pyridine hydrobromide.

Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73870-24-3, name is 4-(Bromomethyl)pyridine hydrobromide. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 4-(Bromomethyl)pyridine hydrobromide

Sodium hydride {3.0 g, 125 mmol, 10 eq. (5.0 g of 60%> NaH in oil)} was added to a solution of galeterone (1, 5.0 g, 12.9 mmoL, 1 eq.) in THF (80 mL) at 0C under argon atmosphere. A white precipitate formed and after stirring for one minute, DMF (5.0 mL) was added and the reaction mixture was allowed to stir for 10 minutes at room temperature. The reaction mixture was placed at 0C and lithium carbonate (5.0 g, 67.7 mmoL, 5 eq. ) was added, followed immediately by 4-(bromomethyl)pyridine hydrobromide (14, 10 g, 39.5 mmoL, 3 eq.) and the reaction mixture was allowed to stir at 0C for 30 minutes. The reaction mixture was removed from 0C and stirring continued at ambient temperature for 18 hours under argon atmosphere. The color of the reaction mixture changed from clear to dark red during the 18-hour period. After 18 hours, the reaction mixture was placed at 0C, water (30 mL) was added to quench unreacted NaH, and the mixture was stirred for 10 minute. Volatile (THF) were removed in vacuo and water (70 mL) was added to the residue aqueous phase. The aqueous phase was extracted with ethyl acetate (EtOAc) (150 mL x 3). Ethyl acetate extract was washed with brine (80 mL x 2), dried with anhydrous Na2SO4 and concentrated in vacuo to give a dark red crude product. Purification by flash chromatography using 3% MeOH/EtOAc as eluent afforded compound galeterone 3beta-pyridine methoxylate (3) as a white solid (3.78 g, 7.88 mmoL, 61%), mp 177-179C. Rf= 0.31 (5% MeOH/EtOAc).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide.

Reference:
Patent; UNIVERSITY OF MARYLAND, BALTIMORE; NJAR, Vincent C.O.; PURUSHOTTAMACHAR, Puranik; MURIGI, Francis; (33 pag.)WO2017/223320; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 73870-24-3, blongs to pyridine-derivatives compound. SDS of cas: 73870-24-3

Will contain compound 16 (150 mg, 0.386 mmol), Potassium carbonate (138 mg, 1.0 mmol), 4-bromomethylpyridine hydrobromide (102 mg, 0.403 mmol) the mixture with DMF (5 mL) was stirred at room temperature overnight.Water (20 mL) was added and extracted with ethyl acetate (20 mL¡Á3).The combined organic phases were washed sequentially with water (15 mL) and brine (15 mL). Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.The product is purified by column chromatography (200-300 mesh silica gel,Ethyl acetate: dichloromethane = 1:1 to 10:1 elution),2-[4-Methoxy-3-(pyridin-4-ylmethoxy)-phenyl]-5,7-bis(methoxymethoxy)-4H-benzopyran-4-one (17) (144 mg).The yield was 77.8%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Xin Element Pharmaceutical Technology Co., Ltd.; Shi Dongfang; Fu Changjin; Cheng Xi; Gong Weiwei; Gu Jie; Zhang Min; Li Pengfei; Yang Yan; Jin Wenqing; (57 pag.)CN110294732; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

73870-24-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 73870-24-3, name is 4-(Bromomethyl)pyridine hydrobromide, molecular formula is C6H7Br2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Compounds 20-26 (1 equiv.) were dissolved in DMF followed by the addition of potassium carbonate (1 – 3 equiv.) and the corresponding benzyl- or pyridinylderivate (1-2 equiv.). This mixture was allowed to stir at various temperatures and timespans, all of which are further specified at the corresponding compounds reported below. The crude product was then purified by either normal phase or reversed phase flash chromatography to yield compounds 30-36 and 40-46. The exact conditions of these purifications are reported below for each compound individually.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIB VZW; UNIVERSITEIT ANTWERPEN; UNIVERSITEIT GENT; VANDENABEELE, Peter; VANDEN BERGHE, Tom; AUGUSTYNS, Koen; HOFMANS, Sam; VAN DER VEKEN, Pieter; DEVISSCHER, Lars; (66 pag.)WO2019/154795; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem