Category: 7418-65-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 7418-65-7, name is 4-Aminonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 7418-65-7

[00323] Compound A9 (3 g, 21.72 mmol) in MeOH (50 mL) was cooled to 0 C and H2S04 was added dropwise, after the addition, the mixture was stirred at 0 C for 30 mm, then the mixture was heated to 80 C overnight. TLC showed the reaction was completed, the mixture was acidized to pH 8 with NaHCO3, then the solution was extracted with EA three times, the organic layer was washed with water and brine, dried over Na2SO4, evaporated to get the product A9-1 (3 g, purity : 90% on TLC) without further purification. ?H NMR (400 M, DMSO) 8.66 (s, 2 H), 8.07 (d, J= 6Hz, 1H), 7.27 (s, 2 H), 6.68 (d, J= 5.6 Hz, 1H), 3.81 (s, 3H) ppm.

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Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH; BRADNER, James, E.; MCKEOWN, Michael, R.; RAHL, Peter, B.; YOUNG, Richard, A.; MARINEAU, Jason, J.; WO2014/71247; (2014); A1;,
Pyridine – Wikipedia,
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Related Products of 7418-65-7, Adding some certain compound to certain chemical reactions, such as: 7418-65-7, name is 4-Aminonicotinic acid,molecular formula is C6H6N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7418-65-7.

(E)-[6-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino]]-3-pyhdinecarboxylic acid (FT104)A suspension of (£)-3-(3,4-dimethoxyphenyl)-2-propenoic acid (1.0 g, 4.8 mmol) in CH2CI2 (10 mL) was treated with oxalyl chloride (1.6 ml_, 19 mmol). The solution was stirred at rt for 1 h and the solvent was removed under reduced pressure to give the acid chloride as a yellow solid. 4-Aminonicotinic acid (0.73 g, 5.3 mmol) was added to a solution of the acid chloride (4.8 mmol) in pyridine (5.0 mL) and the suspension was heated to reflux and stirred for 5 d. The solution was diluted with water and the precipitate was collected by filtration providing (£)-[6-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2- propenyl]amino]]-3-pyridinecarboxylic acid (0.25 g, 16%) as a colourless solid; mp 258- 260 0C; deltaH (500 MHz, DMSO-d6) 3.80 (s, 3H, OCH3), 3.83 (s, 3H, OCH3), 6.82 (d, J = 15.5 Hz, 1H1 CH=CHCO), 7.00 (d, J5.ibeta. = 8.0 Hz, 1 H, H5′), 7.23 (dd, J6.>beta. = 8.0, J2,6. = 2.0 Hz, 1 H1 H6′), 7.33 (s, J2, 6. = 2.0 Hz, 1H, H2′), 7.62 (d, J = 15.5 Hz, 1H, CH=CHCO), 8.60 (d, J5,6 = 8.0 Hz, 1 H, H5), 8.63 (d, J5j6 = 8.0 Hz, 1H, H6), 9.03 (s, 1H, H2); HRMS (ESI) calculated for C17H14N2O4 [M+H]+ 329.1132, found 329.1129; vmax 1140, 1262, 1488, 1623, 2938, 3543 cm”1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7418-65-7, 4-Aminonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FIBROTECH THERAPEUTICS PTY LTD; WILLIAMS, Spencer John; ZAMMIT, Steven; KELLY, Darren James; JAMES, Ian William; WO2010/144959; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7418-65-7, name is 4-Aminonicotinic acid. A new synthetic method of this compound is introduced below., Quality Control of 4-Aminonicotinic acid

Example 88; 7V-Methyl-4-(2-(2-oxoindolin-5-ylaniino)-5-(trifluoromethyl)pyridin-4- ylamino)nicotinamide; 4-Amino-lambda’-inethylnicotinamide; To the mixture of 4-aminonicotinic acid (691 mg, 5.0 mmol), methylamine hydrogen chloride (410 mg, 1.2 eq), EDC (1.15 g, 1.2 eq), HOBt (810 mg, 1.2 eq) in DMF (2OmL) was added DIEA (3.0 mL, 3.0 eq). The mixture was stirred at room temperature overnight. It was concentrated and dissolved in EtOAc. It was washed with saturated NaHCO3 solution. It was concentrated and purified by silica gel with chromatography (0%~20% MeOH/DCM) to obtain the desired product 4-amino-7V- methylnicotinamide.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 7418-65-7, 4-Aminonicotinic acid.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2008/115369; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 7418-65-7 , The common heterocyclic compound, 7418-65-7, name is 4-Aminonicotinic acid, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2-Methyl-4H-pyrido[4,3-d][1,3]oxazin-4-one (17): The suspension of 16 (1.0 g, 7.3 mmol) in 6 mL of acetic anhydride was stirred under reflux for 2 h. The resulting orange solution was cooled to RT. The reaction mixture was concentrated in vacuo and the product was recrystallized from EtOAc to afford 0.65 g of compound 17 (56% yield).

The synthetic route of 7418-65-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HYDRA BIOSCIENCES, INC.; Chong, Jayhong A.; Fanger, Christopher; Larsen, Glenn R.; Moran, Magdalene M.; Ng, Howard; Ripka, Amy; Underwood, Dennis John; Weigele, Manfred; Zhen, Xiaoguang; (83 pag.)US9486455; (2016); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem