Application of 7418-66-8, Adding some certain compound to certain chemical reactions, such as: 7418-66-8, name is 4-Aminonicotinamide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7418-66-8.
To a stirred solution of 4-aminopyridine-3-carboxamide (500 mg, 3.65 mmol), 4-tert-butoxy-4-oxo-butanoic acid (762 mg, 4.38 mmol), TEA (1 mL, 7.29 mmol) in DMF (10 mL), 50%T3P solution in EtOAc (3.5 mL, 5.5 mmol) was added at RT and stirred for 12 h (TLCindicated complete consumption of starting material). The reaction mixture was quenchedwith water (50 mL) and extracted with DCM (2 x 35 mL). The combined organic extractswere washed with brine (30 mL), dried over Na2S04, concentrated under reduced pressure togive the crude product which was purified by column chromatography (100-200 silica gel, 20g, 10% MeOH-10% NH40H-DCM) to afford tert-butyl4-[(3-carbamoyl-4-pyridyl)amino]-4-oxo-butanoate (500 mg, 47%) as a yellow solid.1H NMR [400 MHz, CDCh]: J 11.74 (s, 1H), 9.07 (s, 1H), 8.69 (d, J = 5.2 Hz, 1H), 8.52 (d,J = 5.2 Hz, 1H), 7.11 (brs, 1H), 5.83 (brs, 1H), 2.75-2.70 (m, 2H), 2.68-2.63 (m, 2H), 1.44 (s,9H). LCMS (ESI+): m/z: 316.59 [M+Nat.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7418-66-8, 4-Aminonicotinamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
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