Reference of 74409-42-0 ,Some common heterocyclic compound, 74409-42-0, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2,3,5-trimethylpyridine 1-oxide (1.38 kg, 10.1 mol) was charged into 98% sulfuric acid (4.93 kg, 49.3 mol). 97% nitric acid (1.44 kg) was added dropwise to the solution over 50 minutes, and the solution was then heated for 4 hours at 85C. The reaction solution was charged into a mixture of ammonium hydrogencarbonate (10.6 kg) and water (9.0 L), and the resultant mixture was extracted with ethyl acetate (3.0 L × 3). The resultant organic layer was concentrated and then dried overnight under vacuum to obtain 1.50 kg of the title compound.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 74409-42-0, 2,3,5-trimethylpyridine 1-oxide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1875911; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem