Reference of 74420-00-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74420-00-1, name is 4-Amino-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 100 mg (321 pmol) 6-bromo-8-methyl-2H-spiro[cyclohexane-1 3- imidazo[1,5-a]pyridine]-1,5-dione (GAS-No: 1849592-70-6; PGT Int. AppI. (2015), WO 2015200481) and 47 mg (353 pmol) 1 H-pyrrolo[2,3-b]pyridin-4-amine (GAS-No: 74420-00-1) in 12 mL 1 ,4-dioxane was added 314 mg cesium carbonate and the mixture was degassed and purged with argon several times. 20 mg 4,5-bis(diphenylphosphino)-9,9-dim ethylxanthene, 16 mg 2-(dicyclohexyl-phosphino)-2,4,6-triisopropylbiphenyl, 7.7 mg palladium(ll)acetate and 31 mg tris(dibenzylideneacetone)dipalladium(0) were added and the mixture was stirred at 1000 for 2 hours. The mixtu re was concentrated and the residue purified by flash chromatography (Biotage SNAP cartridge NH 28 g,methanol :dichloromethane) followed by preparative TLC (methanol :dichloromethane) to give 8 mg (7%) of the title compound.LC-MS: m/z = 364.5 [M¡ÂH].1HNMR (400 MHz, DMSO-d6), 6 [ppm]= 1 .24 (1 H), 1 .48 (2H), 1 .57-1 .80 (5H), 2.43 (3H),3.03 (2H), 6.48 (1 H), 7.06 (1 H), 7.21 (1 H), 7.35 (1 H), 8.09 (1 H), 8.20 (1 H), 10.04 (1 H), 11.62 (1H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74420-00-1, 4-Amino-1H-pyrrolo[2,3-b]pyridine.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAYER AKTIENGESELLSCHAFT; KLAR, Ulrich; BOHLMANN, Rolf; SCHAeCKE, Heike; SUeLZLE, Detlev; MENZ, Stephan; PANKNIN, Olaf; (249 pag.)WO2018/134148; (2018); A1;,
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