74764-17-3 | Pyridine-derivatives

Related Products of 74764-17-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74764-17-3, name is N1-(Pyridin-2-yl)ethane-1,2-diamine. This compound has unique chemical properties. The synthetic route is as follows.

Step 6 (3S)-8-Amino-9-fluoro-2,3-dihydro-7-oxo-3-phenylmethyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid A mixture of (3S)-8-Amino-9,10-difluoro-2,3-dihydro-7-oxo-3-phenylmethyl-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (76.9 mg, 0.207 mmol), 2-(2-pyridylamino)ethylamine (41.8 mg, 0.303 mmol), and triethylamine (42.1 muL, 0.302 mmol) in DMSO (1.5 mL) was stirred at 100 C. for 3 h. The reaction mixture was poured into ice-water and the resulting precipitates were collected by filtration. Recrystallization of the filtered precipitates from CH2Cl2-EtOH gave (3S)-8-amino-9-fluoro-2,3-dihydro-7-oxo-3-phenylmethyl-10-[2-(2-pyridylamino)ethylamino]-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (55.4 mg, 55%) as a yellow powder. 1H NMR (400 MHz, CDCl3) delta 2.98-3.09 (2H, m), 3.71 (2H, br), 3.82 (2H, br), 3.97 (1H, d, J=11.0 Hz), 4.20 (1H, t, J=7.9 Hz), 4.33 (1H, d, J=11.0 Hz), 4.71 (1H, br), 5.75 (1H, br), 6.25 (2H, br), 6.44 (1H, d, J=7.9 Hz), 6.60 (1H, dd, J=6.7, 5.5 Hz), 7.11 (2H, d, J=6.7 Hz), 7.31-7.43 (4H, m), 8.07 (1H, s), 8.69 (1H, dd, J=5.5, 1.5 Hz), 15.1 (1H, s). HRESIMS (+): 490.19342 (calcd for C26H25FN5O4, 490.18906). [alpha]D27-204 (c 0.313, CHCl3).

According to the analysis of related databases, 74764-17-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Cociorva, Oana; Li, Bei; Szardenings, Katrin; Fukuda, Yasumichi; Nomura, Masahiro; Seto, Shigeki; Yumoto, Kazuhiro; Okada, Kyoko; Nakamura, Ayako; US2007/254866; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 74764-17-3, N1-(Pyridin-2-yl)ethane-1,2-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of N1-(Pyridin-2-yl)ethane-1,2-diamine, blongs to pyridine-derivatives compound. Quality Control of N1-(Pyridin-2-yl)ethane-1,2-diamine

Step 7 5-Amino-6-fluoro-1,4-dihydro-4-oxo-1-(tetrahydropyran-4-yl)-7-[2-(2-pyridylamino)ethylamino]-3-quinolinecarboxylic Acid A mixture of 5-amino-6,7-difluoro-1,4-dihydro-4-oxo-1-(tetrahydropyran-4-yl)-3-quinolinecarboxylic acid (45.0 mg, 0.139 mmol), 2-(2-pyridylamino)ethylamine (29.0 mg, 0.211 mmol), and triethylamine (0.029 mL, 0.209 mmol) in DMSO (1.0 mL) was stirred at 120 C. for 3 h. After dilution of the reaction mixture with 10% MeOH in CHCl3, the whole mixture washed with water, and the washing was extracted with 10% MeOH in CHCl3 two times. The combined the organic layer and the extracts washed with water, dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. Flash chromatography of the residue (10% MeOH in CHCl3) gave 5-Amino-6-fluoro-1,4-dihydro-4-oxo-1-(tetrahydropyran-4-yl)-7-[2-(2-pyridylamino)ethylamino]-3-quinolinecarboxylic Acid (54.0 mg, 88%) as a white powder. 1H NMR (400 MHz, DMSO-d6) delta 1.88-2.02 (4H, m), 3.40-3.60 (6H, m), 3.94-3.98 (2H, m), 4.71-4.78 (1H, m), 6.18 (1H, d, J=6.7 Hz), 6.46-6.51 (2H, m), 6.75 (1H, t, J=6.1 Hz), 6.94 (1H, br), 7.20 (1H, br), 7.34-7.38 (1H, m), 7.98-7.99 (1H, m), 8.47 (1H, s), 15.5 (1H, s). MS (ESI+) m/z 442 (M++H).

The synthetic route of 74764-17-3 has been constantly updated, and we look forward to future research findings.

Category: 74764-17-3

22-Sep News Extracurricular laboratory: Synthetic route of 74764-17-3

Sources of common compounds: 74764-17-3