Category: 74784-70-6

Related Products of 74784-70-6, Adding some certain compound to certain chemical reactions, such as: 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine,molecular formula is C6H5F3N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74784-70-6.

Example 100 [6-TRIFLUOROMETHYL-2- [4- (3-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL]-3H-] [IMIDAZO [4, 5-B] PYRIDINE,] trifluoroacetic acid salt. (a) [3-NITRO-5-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE.] To a 250-mL, round-bottomed flask was added [5-TRIFLUOROMETHYL-PYRIDIN-] 2-ylamine (8.3 g, 51.2 mmol, Matrix Scientific) and H2SO4 (49 mL). The resulting mixture was cooled to [0 C,] and [HN03] (8.2 mL) was added dropwise. The mixture was heated to [80 C] for [48] h, cooled to room temperature and added dropwise into a vigorously stirred ice-water (500 mL). After the addition, the mixture was basified to pH 9 with [1 ON NAOH] and extracted with EtOAc (2 x [500] mL). The combined organic extracts were dried over [MGS04] and filtered. The solvent was removed in vacuo and the residue was purified by silica gel column chromatography, eluting with [ETOAC/HEXANE] (1: 2) to give the title compound as a yellow solid. MS (ESI, positive ion) m/z: 208 (M+1).

According to the analysis of related databases, 74784-70-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2004/35549; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 74784-70-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74784-70-6 as follows.

To a de-gassed mixture of 3- [3- (trifluoromethyl) pyridin-2-yl] pyrido [2,3-b] pyrazin-8- amine (72 mg, 0.25 MMOL), cesium carbonate (162 mg, 0.5 mmol), 2-amino-trifluoromethyl pyridine (45 mg, 0.25 mmol) in dioxane (5 mL) under nitrogen, add PD2DBA3 (11 mg) and xantphos (7 MG). Stir the mixture AT 100C for 3 hours, cool, add water (10 mL) and extract with EtOAc. Dry over NA2SO4, concentrate under vacuum. Purify by chromatography eluting with DICHLOROMETHANE/METHANOL/AMMONIUM hydroxide mixture to give the title compound. MS 437 (M + 1).’H NMR 6 (CDCI3) 9.42 (1H, s), 9.28 (1H, s), 9.11 (1H, d), 8.95 (1H, d), 8. 90 (IH, d), 8.72 (1H, s), 8.25 (1H, d), 7.89 (1H, d), 7.61 (1H, dd), 7.13 (1H, d).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74784-70-6, its application will become more common.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7652; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74784-70-6 ,Some common heterocyclic compound, 74784-70-6, molecular formula is C6H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 614-(Aminomethyl)-l-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-N-(5-(trifluoromethyl)pyridin-2- yl)piperidine-4-carboxamide; 6 IA. ferf-Butyl 4-cyano-4-(5-(trifluoromethyl)pyridin-2-ylcarbamoyl)piperidine- 1 – carboxylateHATU (1121 mg, 2.95 mmol) was added in one portion to l-(tert-butoxycarbonyl)-4- cyanopiperidine-4-carboxylic acid (Example 26A) (500mg, 1.97 mmol) and DIPEA (1.030 ml, 5.90 mmol) in DMA (5ml) at 2O0C under nitrogen. The resulting solution was stirred at 20 0C for 10 minutes then 2-amino-5-(trifluoromethyl)pyridine (383 mg, 2.36 mmol) added. The reaction mixture was stirred at 50 0C for 6 hours then at 20 0C for 18 hours. The reaction mixture was diluted with EtOAc (50 mL), and washed sequentially with water (2 x 50 mL) and saturated brine (50 mL). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 20 to 40% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford and triturated with diethyl ether to afford tert-butyl 4- cyano-4-(5-(trifluoromethyl)pyridin-2-ylcarbamoyl)piperidine-l -carboxylate (554 mg, 70.7 %) as a white solid.IH NMR (400.13 MHz, DMSO-d6) delta 1.42 (9H, s), 2.00 – 2.07 (2H, m), 2.25 (2H, d), 2.97 (2H, s), 4.04 (2H, d), 8.19 – 8.27 (2H, m), 8.80 (IH, t), 11.38 (IH, s) MS m/e M-H 397

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 74784-70-6, 5-(Trifluoromethyl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74784-70-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, molecular weight is 162.1125, as common compound, the synthetic route is as follows.

Sodium hydride (60% in paraffin oil, 0.0907 g, 2.27 mmol) was washed twice under Ar with n-hexane (2 ml). A solution of 2-amino-5-chloropyridine (0.250 g, 1.51 mmol) in 2-MeTHF (2.0 ml) was added slowly. The brown-red suspension was stirred until no more gas evolution was observed and then 3-methyl-2-oxazolidinone (0.3 12 g, 3.02 mmol) wasadded. The resulting reaction mixture was stirred at room temperature for 20 h. The reaction was quenched by careful addition of water and diluted with EtOAc. Phases were separated and aqueous phase was extracted with EtOAc (2x). The combined organic layers were washed with brine, dried over anhydrous Na2504 and evaporated under reduced pressure to afford a crude residue (0.457 g). Quantitative 1H NMR analysis using trimethoxy benzeneas an internal standard indicated purity of 45% (52% chemical yield). The crude product was purified by silica gel chromatography (eluting with 1-4% MeOH in DCM) to afford 1-(2- hydroxyethyl)-1 -methyl-3-[5-(trifluoromethyl)-2-pyridyl]urea (0.177 g, 99% purity, 44%) as a pale yellow solid.1H NMR (400MHz, d6DMSO) 69.56 (br, 1H), 8.56 (dd, J = 1.5, 0.7 Hz, 1H), 8.03 (dd, J =9.0, 2.6 Hz, 1H), 7.97-7.93 (m, 1H), 5.42 (br, 1H), 3.62 (q, J = 4.9 Hz, 2H), 3.46-3.38 (m,2H), 2.96 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 74784-70-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; SMITS, Helmars; GHORAI, Sujit, Kumar; (25 pag.)WO2017/186624; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 74784-70-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a sealed tube, dissolve 4-(5-chloro-l,8-naphthyridin-2-yl)-5-(trifluoromethyl)- pyrimidin-2-ol (237 mg, 0.725 mmol), 2-amino-5-trifluoromethyl-pyridme (176 mg, 1.09 mmol), and CS2CO3 (709 mg, 2.18 mmol) in dry dioxane (7 mL). Bubble argon through the solution for five minutes. Add Pd2dba3 (66 mg, 0.0725 mmol) and xantphos (42 mg, 0.0725 mmol) and bubble argon through the solution for an additional five minutes. Seal the tube and heat at HOC overnight. Cool the mixture and dilute with Et2O. Filter the solution through Celite. Discard the filtrate. Wash the Celite bed with MeOH. Concentrate the methanolic filtrate under reduced pressure. Purify the crude residue by silica gel chromatography eluting with CH2Cl2ZMeOH (90/10) to yield the title compound. LC/MS (MH+) 453.10.

According to the analysis of related databases, 74784-70-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROGEN CORPORATION; WO2006/81388; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74784-70-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 74784-70-6 as follows.

Step A: 3-nitro-5-(trifluoromethyl) pyridin-2-amine To a solution of 5~(trifluoromethyl)pyridine-2-amine (l.lg, 6.79mmol) dissolved in sulfuric acid (2OmL) at room temperature was added nitric acid (0.475 g, 6.79mmol). After heating to 700C for Ihr, the reaction mixture was cooled to room temperature and diluted with EtOAc and ice. The organic layer was separated, washed with sat. sodium bicarbonate aq. and brine, dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure and chromatographed on silica gel eluting with a gradient solvent mixture (5% MeOH-DCM to 15% MeOH-DCM) to give the title compound (680 mg). LC/MS: m/z 208(M+H). 1H-NMR (500MHz, CD3OD): delta 8.60 (d, 1H), 8.67 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,74784-70-6, its application will become more common.

Reference:
Patent; MERCK & CO., INC.; WO2009/152072; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74784-70-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, molecular weight is 162.1125, as common compound, the synthetic route is as follows.

EXAMPLE 13-(4-Methylsulfonyl)phenyl-2-pyrrolidin-1-yl-5-trifluoromethylpyridineStep 1: 2-Amino-3-bromo-5-trifluoromethylpyridine To a solution of 2-amino-5-trifluoromethylpyridine (9 g) in acetic acid (75 mL) at r.t. was added bromine (5.8 mL) slowly. After 1 h, the acid was neutralized by the careful addition of sodium hydroxide (10 N) at 0C. The resulting orange precipitate was dissolved in ether and washed successively with saturated potassium carbonate, saturated Na2SO3 and brine, dried and concentrated. The residual solid was stirred vigorously in hexane for 1 h to provide, after filtration, the title compound as a white solid (10.2 g).

Statistics shows that 74784-70-6 is playing an increasingly important role. we look forward to future research findings about 5-(Trifluoromethyl)pyridin-2-amine.

Reference:
Patent; MERCK FROSST CANADA & CO.; EP1015431; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 74784-70-6

Phenyl chloroformate (620mg, 3.96 mmol) was added to a solution of 5-(trifluoromethyl)pyridin-2-amine (615 mg, 3.79 mmol) and pyridine (323 mg, 4.08 mmol) in ACN (50 mL) at 0C. After stirring the solution overnight at room temperature, the reaction was quenched with H20. The resulting precipitate was filtered, dried and used without further purification. The product was a white solid (905mg, 3.21 mmol, 84% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74784-70-6, 5-(Trifluoromethyl)pyridin-2-amine.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce; KODANI, Sean; (110 pag.)WO2017/160861; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74784-70-6, name is 5-(Trifluoromethyl)pyridin-2-amine, molecular formula is C6H5F3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 5-(Trifluoromethyl)pyridin-2-amine

To a solution of phenyl carbonochloridate (1.72 g, 1 1.0 mmol) in dichloromethane (20.0 ml_) was added 5-(trifluoromethyl)pyridin-2-amine (1.62 g, 10.0 mmol) at room temperature under N2. Pyridine (0.870 g, 1 1.0 mmol) was then added to the reaction at 0 C and the resulting mixture stirred for 0.5 h. The reaction mixture was poured into water and extracted with ethyl acetate followed by drying with sodium sulfate. After concentration, the residue was purified with the column chromatography (eluent: dichloromethane: petroleum ether (1 :2)) to afford 1.2 g of the title compound. NMR (400 MHz, DMSO) d 1 1 .24 (s, 1 H), 8.70 (d, J = 0.9 Hz, 1 H), 8.18 (dd, J = 8.9, 2.3 Hz, 1 H), 7.99 (d, J = 8.8 Hz, 1 H), 7.43 (dd, J = 1 1.0, 4.8 Hz, 2H), 7.31 – 7.18 (m, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 74784-70-6.

Reference:
Patent; SYNGENTA CROP PROTECTION AG; SYNGENTA CHINA INVESTMENT COMPANY LIMITED; SCHAETZER, Juergen, Harry; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; STOLLER, Andre; GAGNEPAIN, Julien, Daniel, Henri; HALL, Roger, Graham; RENDINE, Stefano; LU, Long; YANG, Jianzhong; CHEN, Ruifang; (113 pag.)WO2020/30754; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 74784-70-6 ,Some common heterocyclic compound, 74784-70-6, molecular formula is C6H5F3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of l-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)-4-methyl-iH-pyrazole-3- carboxylic acid (1.00 g, 2.65 mmol) in DCM (20 ml) was added 5 drops of DMF followed by 5 ml oxalyl chloride. The reaction mixture was stirred for one hour at room temperature, concentrated and the crude acid chloride redissolved in DCM (20 ml). DMAP (0.98 g, 8.03 mmol) was added followed by 5-(trifluoromethyl)pyridine-2-amine (0.49 g, 3 mmol). The reaction mixture was stirred at room temperature overnight then water was added and the product extracted with DCM (x2). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Flash chromatography (heptane – heptane : EtOAc 90 : 10) gave 0.67 g (49%) of the title compound as a colorless solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 74784-70-6, 5-(Trifluoromethyl)pyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67443; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem