Category: 74976-31-1

Synthetic Route of 74976-31-1, Adding some certain compound to certain chemical reactions, such as: 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine,molecular formula is C7H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 74976-31-1.

To a solution of6-chloro-1H-pyrrolo[3,2-c]pyridine (5.00 g, 32.8 mmol) in DMF(20 mL) was added NaH (1.57 g, 39.3 mmol) at 0C. The reaction mixture was stirred for1 h, then SEM-Cl (6.56 g, 39.3 mmol) was added at 0C. The reaction mixture wasstirred at room temperature for 1 h, then quenched with HzO (100 mL) and extracted withDCM (3 x 100 mL). The organic layer was separated and washed with brine (3 x 10025 mL), then dried over anhydrous NazS04 and concentrated in vacuo. The crude materialwas purified by column chromatography (10-15% EtOAc in hexanes) to afford the titlecompound (7.00 g, 75%) as a yellow oil. DH (400 MHz, CD30D) -0.07 (s, 9H), 0.87 (t, J7.83 Hz, 2H), 3.52 (t, J7.83 Hz, 2H), 5.57 (s, 2H), 6.71 (d, J2.93 Hz, 1H), 7.50 (d, J3.42Hz, 1H), 7.64 (s, 1H), 8.61 (s, 1H). HPLC-MS (method 6): MH+ m/z 283.3, RT 2.1230 minutes.

According to the analysis of related databases, 74976-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; DEBOVES, Herve Jean Claude; FOLEY, Anne Marie; FOULKES, Gregory; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; QUINCEY, Joanna Rachel; SCHULZE, Monika-Sarah Elisabeth Dorothea; SELBY, Matthew Duncan; SMALLEY, Adam Peter; TAYLOR, Richard David; TOWNSEND, Robert James; ZHU, Zhaoning; (278 pag.)WO2018/229079; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 74976-31-1 , The common heterocyclic compound, 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C7H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-chloro-1H-pyrrolo[3,2-c]pyridine (153 mg, 1.00 mmol) in DMF (5 mL) were added PhSO2Cl (195 mg, 1.10 mmol) and Cs2CO3 (653 mg, 2.01 mmol), and the resulting mixture was stirred at 60 C. for 3 h then concentrated under reduced pressure. The residue was treated with H2O (20 mL), and the mixture was extracted with EtOAc (3*10 mL). The combined organic layers were washed with sat. aq. NaCl, dried over MgSO4, filtered and concentrated under reduced pressure to give the crude title compound as a yellow solid (290 g, 99%), which was used without further purification. MS (ES+) C13H9ClN2O2S requires: 292, found: 293 [M+H]+.

The synthetic route of 74976-31-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; JONES, Philip; CROSS, Jason Bryant; CARROLL, Christopher L.; MCAFOOS, Timothy Joseph; MANDAL, Pijus Kumar; US2019/298729; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74976-31-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

6-chloro-i H-pyrrolo[3,2-c]pyridine (100 mg) and 2-bromopyrimidine (83 mg) was taken in Dioxane (3 ml) along with K3P04 (300 mg), diaminocyclohexane (ii mg) and Cul (6 mg). The reaction mixture was purged with Nitrogen and heated tol 10 00 for 1.2 hrs in microwave. The reaction mass was quenched with the addition of water and extracted with ethyl acetate. The ethyl acetate layer was dried and concentrated under reduced pressure to obatained the crudeproduct. The crude product was purified using silica gel column chromatography to obtaine pure product (80 mg).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74976-31-1, 6-Chloro-1H-pyrrolo[3,2-c]pyridine.

Reference:
Patent; BASF SE; VYAS, Devendra; VALLINAYAGAM, Ramakrishnan; SHINDE, Harish; SAMBASIVAN, Sunderraman; ADISECHAN, Ashokkumar; WACH, Jean-Yves; (91 pag.)WO2017/45955; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 74976-31-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74976-31-1, name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

Into a 100 mL 3-necked round-bottom flask was added a solution of 6-chloro- lH-pyrrolo [3, 2- c]pyridine (1.00 g, 6.55 mmol) in N,N-dimethylformamide (10 mL), potassium hydroxide (1.40 g, 24.9 mmol). The reaction mixture was stirred for 20 min at room temperature, then I2 (1.66 g, 6.54 mmol, 1.00) was added to the solution. The reaction mixture was stirred for additional 30 min at room temperature. The reaction mixture was diluted with H20 (50 mL) and the solids were collected by filtration. The solids were dried under reduced pressure overnight to afford 6-chloro- 3-iodo-lH-pyrrolo[3,2-c]pyridine (1.70 g, 93.0%) as a yellow solid. LCMS (ESI): RT (min) = 1.321, [M+H]+ = 279, method = N.

According to the analysis of related databases, 74976-31-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; HANAN, Emily; HEFFRON, Timothy; PURKEY, Hans; ELLIOTT, Richard Leonard; HEALD, Robert; KNIGHT, Jamie; LAINCHBURY, Michael; SEWARD, Eileen M.; WO2014/81718; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, SMILES is ClC1=CC(NC=C2)=C2C=N1, in an article , author is Wahyuono, Ruri Agung, once mentioned of 74976-31-1, Name: 6-Chloro-1H-pyrrolo[3,2-c]pyridine.

Structure of Ni(OH)(2) intermediates determines the efficiency of NiO-based photocathodes – a case study using novel mesoporous NiO nanostars

We report the wet chemical synthesis of mesoporous NiO nanostars (NS) as photocathode material for dye-sensitized solar cells (DSSCs). The growth mechanism of NiO NS as a new morphology of NiO is assessed by TEM and spectroscopic investigations. The NiO NS are obtained upon annealing of preformed beta-Ni(OH)(2) into pristine NiO with low defect concentrations and favorable electronic configuration for dye sensitization. The NiO NS consist of fibers self-assembled from nanoparticles yielding a specific surface area of 44.9 m(2) g(-1). They possess a band gap of 3.83 eV and can be sensitized by molecular photosensitizers bearing a range of anchoring groups, e.g. carboxylic acid, phosphonic acid, and pyridine. The performance of NiO NS-based photocathodes in photoelectrochemical application is compared to that of other NiO morphologies, i.e. nanoparticles and nanoflakes, under identical conditions. Sensitization of NiO NS with the benchmark organic dye P1 leads to p-DSSCs with a high photocurrent up to 3.91 mA cm(-2) whilst the photoelectrochemical activity of the NiO NS photocathode in aqueous medium in the presence of an irreversible electron acceptor is reflected by generation of a photocurrent up to 23 mu A cm(-2).

Interested yet? Read on for other articles about 74976-31-1, you can contact me at any time and look forward to more communication. Name: 6-Chloro-1H-pyrrolo[3,2-c]pyridine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry, like all the natural sciences, HPLC of Formula: C7H5ClN2, begins with the direct observation of nature— in this case, of matter.74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, SMILES is ClC1=CC(NC=C2)=C2C=N1, belongs to pyridine-derivatives compound. In a document, author is Li, Jun-Xia, introduce the new discover.

Two mononuclear zinc(II) complexes constructed by two types of phenoxyacetic acid ligands: syntheses, crystal structures and fluorescence properties

Two new mononuclear complexes, [Zn(3-Hcpa)(2)(H2O)(4)] (1) and [Zn(3,5,6-tcpa)(2)(H2O)(4)] [Zn(3,5,6-tcpa)(2)(H2O)(2)] (2) (3-H(2)cpa=3-carboxy-phenoxyacetic acid, 3,5,6-Htcpa=3,5,6-trichloro pyridine-2-oxyacetic acid), were synthesized and structurally characterized. The single-crystal X-ray diffraction analysis showed that in 1 the Zn-II ion lies on an inversion center of an octahedron formed by four aqua ligands and two carboxy oxygen atoms of two unidentate 3-Hcpa(-) anions in trans-arrangement. Complex 2 is a co-crystal consisting of two discrete and stereochemically different complexes: one with an octahedrally, and the other a tetrahedrally coordinated zinc center. The six-coordination about the first Zn-II ion comprises four oxygen atoms from water (H2O) molecules and two from the carboxy groups of monodentate trans-related 3,5,6-tcpa(-) ligands. The four-coordination about the second Zn-II ion is comprised of two H2O ligands and two unidentate carboxy oxygen atoms from 3,5,6-tcpa(-) ligands. O-H center dot center dot center dot O hydrogen bond and/or Cl center dot center dot center dot Cl halogen bond interactions play an important part in construction of the three-dimensional (3D) networks for 1 and 2. The photoluminescence spectra reveal that both 1 and 2 display luminescent properties in the violet region.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 74976-31-1. HPLC of Formula: C7H5ClN2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C7H5ClN2, belongs to pyridine-derivatives compound, is a common compound. In a patnet, author is Nemati, Firouzeh, once mentioned the new application about 74976-31-1, Recommanded Product: 74976-31-1.

Cu2O/Nano-CuFe2O4 as a Magnetically Recoverable Catalyst for Ligand-Free Synthesis of Imidazo[1,2-a] Pyridines and 3-Aroylimidazo[1,2-a] Pyridines

Cu2O/nano-CuFe2O4 was found as an efficient and magnetically separable heterogeneous catalyst for the solvent-free synthesis of imidazo[1,2-a] pyridine derivatives. This nano-magnetic composite is also extended as a well-run and recoverable catalyst for the synthesis of 3-aroylimidazo[1,2-a] pyridine derivatives using air as the green oxidant under ligand and additive-free conditions. Readily available, inexpensive starting materials, simple procedure, short reaction time, ease of preparation of the catalyst, stability the catalyst to air and compatibility it with a wide variety of substrates are merits of the presented methodology. Furthermore, the catalyst was easily separated by an external magnet. It recovered and reused five times without significant loss of catalytic activity.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 74976-31-1. The above is the message from the blog manager. Recommanded Product: 74976-31-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C7H5ClN2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, molecular formula is C7H5ClN2. In an article, author is Jin, Songyang,once mentioned of 74976-31-1.

Phosphoric Acid Mediated Light-Induced Minisci C-H Alkylation of N-Heteroarenes

Herein, we report an environmentally-friendly light-induced Minisci alkylation of N-heteroarenes with a broad substrate scope using diphenyl phosphate as catalyst under metal- and photocatalyst-free conditions. The radical precursor redox-active esters (RAEs) were introduced as alkylating reagents for the functionalization of N-heteroarene derivatives including pyridine, quinoline, and isoquinoline. Mechanistic studies suggested that diphenyl phosphate played a key role via hydrogen bonding in the catalytic cycle.

If you¡¯re interested in learning more about 74976-31-1. The above is the message from the blog manager. COA of Formula: C7H5ClN2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Synthetic Route of 74976-31-1, Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. The appropriate choice of redox mediator can avoid electrode passivation and overpotential. 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, SMILES is ClC1=CC(NC=C2)=C2C=N1, belongs to pyridine-derivatives compound. In a article, author is Cisneros, Sebastian, introduce new discover of the category.

Effects of SiO2-doping on high-surface-area Ru/TiO2 catalysts for the selective CO methanation

Aiming at a better understanding of the role of electronic / chemical modifications of the support on the per-formance of high specific surface area Ru/TiO2 catalysts in the selective CO methanation, we prepared and examined four different Ru/TiO2 catalysts with similar Ru loading and similar high specific surface area, but with the support doped with different amounts of Si (0-12 wt.% SiO2). Their activity for methane formation exhibits a volcano-shaped dependence on the SiO2 content, with a maximum between 4 and 8 wt.%. The CO adsorption properties showed distinct differences, with the weakest CO adsorption strength for the most active catalysts. Based on the results of a variety of different characterization techniques and pyrrole/pyridine adsorption measurements, the higher activity / lower CO adsorption strength cannot be explained by a single property, such as particle size, but must rather be caused by a complex combination of different effects.

Synthetic Route of 74976-31-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 74976-31-1.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 74976-31-1, Name is 6-Chloro-1H-pyrrolo[3,2-c]pyridine, formurla is C7H5ClN2. In a document, author is Wang, Yonghui, introducing its new discovery. Computed Properties of C7H5ClN2.

Self-assembled flower-like MnO2 grown on Fe-containing urea-formaldehyde resins based carbon as catalyst for oxygen reduction reaction in alkaline direct methanol fuel cells

The urea-formaldehyde resins carbon (UFC) and Fe-containing UFC (Fe-UFC) have been prepared by direct carbonization of urea-formaldehyde resins (UF resins) without any surfactants. On this basis, N-doped materials of UFC/MnO2 and Fe-UFC/MnO2 composites were successfully synthesized by the situ redox method. UF resins played both roles of carbon source and nitrogen source. The specific surface areas are 265.7m(2).g(-1) and 229.4 m(2).g(-1) for UFC/MnO2 and Fe-UFC/MnO2, respectively. Direct methanol fuel cells (DMFCs) were assembled with the prepared catalyst as cathode catalyst, polymer fiber membrane (PFM) as electrolyte film and PtRu/C as anode catalyst. DMFCs and cyclic voltammetry (CV) performance tests indicate that Fe-UFC/MnO2-based DMFC displays superior oxygen reduction reaction (ORR) catalytic activity than UFC/MnO2 owing to Fe-N-x existing and a large number of pyridine-N in Fe-UFC/MnO2. The lone pair electrons of pyridine-N can coordinate with transition metal elements and form Fe-N-x groups on Fe-UFC/MnO2, which can be used as the electrocatalytic active sites for ORR. On the other hand, the presence of iron on the prepared catalyst can reduce the band gap, facilitate the transfer from Mn-III to Mn-IV, and provide free electrons for adsorbed O-2 or active oxygen species, thus accelerating the conductivity and ORR catalytic efficiency.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 74976-31-1 help many people in the next few years. Computed Properties of C7H5ClN2.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem