Category: 75073-11-9

Application of 75073-11-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75073-11-9, name is 5-Iodo-6-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of concentrated hydrochloride acid (233ml_) at 0C was added 5-iodo-6-methyl-pyridin-2-ylamine (25 g, 107 mmol, 1 eq) followed by addition of pre-dissolved sodium nitrite (29.5g, 427mmol, 4eq) in water (150ml_) in drop wise manner over period of 30 minutes. Resulting reaction mixture was stirred at room temperature for 16 hours. After complete consumption of starting material, reaction mixture was cooled to 0C, and pH was adjusted to 12 by saturated aqueous sodium hydroxide solution, extracted with DCM (3x200ml_). Combined organic layer was dried over anhydrous Na2S04 and concentrated under reduced pressure to get brown oil (20g, crude). Crude was purified by column chromatography using silica gel (100-200 mesh). Desired compound was eluted at 4% ethyl acetate in hexane to get title compound as brown oil (8g, 30%). H NMR (400 MHz, CDCI3)8: 2.69 (s, 3H), 6.88 (d, J = 8.04 Hz, 1 H), 7.95 (d, J = 8.24 Hz, 1 H). LC-MS (m/z): 254.0 (M+H).

According to the analysis of related databases, 75073-11-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZOETIS LLC; MENON, Sanjay; SHEEHAN, Susan M.K.; VAILLIANCOURT, Valerie A.; WO2014/39484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 75073-11-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 75073-11-9, name is 5-Iodo-6-methylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of concentrated hydrochloride acid (233ml_) at 0C was added 5-iodo-6-methyl-pyridin-2-ylamine (25 g, 107 mmol, 1 eq) followed by addition of pre-dissolved sodium nitrite (29.5g, 427mmol, 4eq) in water (150ml_) in drop wise manner over period of 30 minutes. Resulting reaction mixture was stirred at room temperature for 16 hours. After complete consumption of starting material, reaction mixture was cooled to 0C, and pH was adjusted to 12 by saturated aqueous sodium hydroxide solution, extracted with DCM (3x200ml_). Combined organic layer was dried over anhydrous Na2S04 and concentrated under reduced pressure to get brown oil (20g, crude). Crude was purified by column chromatography using silica gel (100-200 mesh). Desired compound was eluted at 4% ethyl acetate in hexane to get title compound as brown oil (8g, 30%). H NMR (400 MHz, CDCI3)8: 2.69 (s, 3H), 6.88 (d, J = 8.04 Hz, 1 H), 7.95 (d, J = 8.24 Hz, 1 H). LC-MS (m/z): 254.0 (M+H).

According to the analysis of related databases, 75073-11-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZOETIS LLC; MENON, Sanjay; SHEEHAN, Susan M.K.; VAILLIANCOURT, Valerie A.; WO2014/39484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 75073-11-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.75073-11-9, name is 5-Iodo-6-methylpyridin-2-amine, molecular formula is C6H7IN2, molecular weight is 234.04, as common compound, the synthetic route is as follows.

PREPARATION 3 Diethyl 2-{[(5-iodo-6-methyl-2-pyridinyl)amino]methylene}malonate A solution of 2-amino-5-iodo-6-picoline (Prep 2 4.48 g) and diethyl ethoxymethylenemalonate (4.25 mL) is heated at 95 C. for 1.5 h. The reaction is cooled to room temperature. Hexanes (20 mL) are added and the resulting solid is filtered, washed with a minimal amount of hexanes, and dried to give the desired enamine (6.45 g, 83%). Physical Characteristics are as follows: m.p. 138-139 C.; 1H NMR (300 MHz, DMSO-d6) delta 10.70, 8.96, 8.11, 7.03, 4.21, 4.14, 1.26, 1.24; IR (drift) 2989, 1686, 1641, 1603, 1568, 1548, 1421, 1373, 1363, 1333, 1272, 1251, 1232, 1211, 800 cm-1; MS (ESI) m/z 404.9 (M+H)+, 402.9 (M-H)-; Anal. Calcd for C14H17IN2O4: C, 41.60; H, 4.24; N, 6.93; Found: C, 41.68; H, 4.35; N, 6.83.

Statistics shows that 75073-11-9 is playing an increasingly important role. we look forward to future research findings about 5-Iodo-6-methylpyridin-2-amine.

Reference:
Patent; Vaillancourt, Valerie A.; US2002/7066; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem