Category: 75308-46-2

Adding a certain compound to certain chemical reactions, such as: 75308-46-2, tert-Butyl 2,6-dichloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 75308-46-2, blongs to pyridine-derivatives compound. SDS of cas: 75308-46-2

To a solution of tert-butyl 2,6-dichloroisonicotinate (1 1.0 g, 44.3 mmol) in ethanol (222 mL) was added hydrazine hydrate (6.46 mL, 133 mmol). The mixture was heated 75 0C. After 18 h, the mixture was cooled to ambient temperature. The mixture was concentrate down to half of the volume. The solid crashed out was filtered off and the filtrate was concentrated to dryness: LC-MS [M+l] = 244.1.

The synthetic route of 75308-46-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP &; DOHME CORP.; BURGEY, Christopher, S.; DENG, Zhengwu, J.; NGUYEN, Diem, N.; PAONE, Daniel, V.; POTTEIGER, Craig, M.; STAUFFER, Shaun, R.; SEGERDELL, Carolyn; NOMLAND, Ashley; LIM, John, J.; WO2010/111058; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75308-46-2, name is tert-Butyl 2,6-dichloroisonicotinate. A new synthetic method of this compound is introduced below., Quality Control of tert-Butyl 2,6-dichloroisonicotinate

To a solution of 2,6-dichloro-isonicotinic acid tert.-butyl ester (780 mg, 3.14 mmol), and 2,4,6-trivinylcyclotriboroxane pyridine complex (640 mg, 2.66 mmol, prepared according to F. Kerins, D. F. O’Shea J. Org. Chem. 67 (2002) 4968-4971) in DME (12 mL), a solution of 2 M aq. K2CO3 (3 mL) followed by Pd(PPh3)4 (30 mg, 0.041 mmol) and PPh3 (50 mg, 0.187 mmol) is added. The mixture is stirred at 100 C. for 15 h before it is cooled to rt, diluted with ether and washed with 1 N aq. NaOH solution (3×30 mL). The aq. phase is extracted once more with ether and the combined org. extracts are dried over Na2SO4, filtered and evaporated. The crude product is purified by CC on silica gel eluting with heptane:EA 5:1 to give 2,6-divinyl-isonicotinic acid tert-butyl ester (703 mg) as a colourless oil; LC-MS: tR=1.03 min, [M+1]+=232.01.

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Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2010/63108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 75308-46-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75308-46-2, name is tert-Butyl 2,6-dichloroisonicotinate. A new synthetic method of this compound is introduced below.

To a solution of 2,6-dichloro-isonicotinic acid tert.-butyl ester (3.35 g, 13.5 mmol), Fe(acac)3 (512 mg, 1.45 mmol) and NMP (1.58 g, 16.0 mmol) in THF (400 mL), a solution of methylmagnesium iodide (11.67 g, 70.2 mmol) in THF is slowly added at -77 C. The brown solution turns green-grey. After the addition of about half of the Grignard reagent the dark brown suspension is warmed to it and stirred for 30 min before it is again cooled to -70 C. The other half of the Grignard reagent is added, the mixture turns dark green-brown and is warmed to it and stirred for 16 h. The mixture is cooled to -50 C. and another portion of the Grignard reagent (2.24 g, 13.5 mmol) is added. The reaction mixture is warmed to rt, stirred for 16 h and then carefully quenched with 1 N aq. HCl (100 mL) and diluted with ether. The org. layer is separated and the aq. phase is extracted with ether. The combined org. extracts are dried over MgSO4, filtered and evaporated. The crude product is purified by MPLC on silica gel to give 2,6-dimethylisonicotinic acid tert.-butyl ester (2.37 g) as a pale yellow oil; LC-MS: tR=0.65 min, [M+1]+=208.29.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,75308-46-2, its application will become more common.

Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2010/63108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem