Category: 754131-60-7

Related Products of 754131-60-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of the above crude 3-bromo-2-bromomethylpyridine (70g, 0. 28MOL) in dioxane (SOOML) and water (250mL), was added NACN (28g, 0. 74MOL) at 0C and then stirred at RT for 16h. The reaction mixture was quenched with 3Lit of water and extracted with ethylacetate (4X500ML). The organic layer was washed with water (400L), brine (250mL), dried over NA2SO4 and concentrated to give crude product. The crude was purified by column chromatography over silica gel (pet. ether/ethylacetate, 8: 2) to give 3- BROMOPYRIDINE-2-YL-ACETONITRILE (22g, 40%). [TLC: Pet. ether/ethylacetate, 7: 3, RF= 0. 35] MS (EST) : 199.2 ; MS (ESR) : 197.2.

According to the analysis of related databases, 754131-60-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N. V.; WO2004/98607; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 754131-60-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine. A new synthetic method of this compound is introduced below.

A solution of tert-butyl4-hydroxypiperidin-1-carboxylate (9.63 g) in THF (100 ml)was cooled to 0C, 60% sodium hydride (3.19 g) was added, and the mixture wasstirred for 20 min. To the reaction mixture was added a solution of3-bromo-2-(bromomethyl)pyridine (10.00 g) in THF (100 ml), and the mixture wasstirred at room temperature under an argon atmosphere overnight. To the mixture wasadded water at 0C, and the mixture was extracted with ethyl acetate. The organic layerwas washed with water and saturated brine, dried over anhydrous magnesium sulfate,and the solvent was evaporated under reduced pressure. The residue was purified bysilica gel chromatography (ethyl acetate/hexane) to give the title compound (13.12 g).MS, found: 371.1,373.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,754131-60-7, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 754131-60-7, Adding some certain compound to certain chemical reactions, such as: 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine,molecular formula is C6H5Br2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 754131-60-7.

To a solution of cis-4-phenylcyclohexanol (50.8 g) in THF (300 ml) was added 60%sodium hydride ( 17.29 g) at 0C, and the mixture was stirred for 30 min. To thereaction mixture was added 3-bromo-2-(bromomethyl)pyridine (72.3 g), and themixture was stirred at room temperature overnight. Saturated aqueous ammoniumchloride solution was added, and the mixture was extracted with ethyl acetate. Theextract was washed with saturated brine, dried over anhydrous magnesium sulfate andthe solvent was evaporated under reduced pressure. The residue was purified by silicagel column chromatography (ethyl acetate/hexane) to give the title compound (84.43g).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 754131-60-7, 3-Bromo-2-(bromomethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FUJIMOTO Tatsuhiko; RIKIMARU Kentaro; FUKUDA Koichiro; SUGIMOTO Hiromichi; MATSUMOTO Takahiro; TOKUNAGA Norihito; HIROZANE Mariko; (166 pag.)WO2017/135306; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem