Category: 75418-74-5

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75418-74-5, name is Methyl 3-oxo-3-(pyridin-2-yl)propanoate. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

a Pyridin-2-yl-propynoic acid ethyl ester The title compound was synthesised from commercially available 3-oxo-3-pyridin-2-yl-propionic acid methyl ester using the procedure described in Example 32, step (b), in 76% yield. 1H NMR (CDCl3) delta8.66 (d, J=4.8 Hz, 1H), 7.73 (m, 1H), 7.59 (d, J=7.8 Hz, 1H), 7.36 (m, 1H), 4.31 (q, J=7.1 Hz, 2H), 1.35 (t, J=7.1 Hz, 3H).

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Reference:
Patent; 3-Dimensional Pharmaceuticals, Inc.; US2002/169200; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 75418-74-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 75418-74-5, name is Methyl 3-oxo-3-(pyridin-2-yl)propanoate, molecular formula is C9H9NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 2: 5-Pyridin-2-ylthieno[3,2-b]pyridin-7-ol; 3-Thienylamine oxylate (5.55 g, 30 mmol, 1.0 equiv) and methyl 3-oxo-3-pyridin-2- ylpropanoate (5.67 g, 30 mmol, 1.0 equiv) were combined in a round bottom flask equipped with a Dean Stark reflux condenser and taken up in anhydrous toluene (100 mL). 4N HCI in 1 ,4-dioxane (0.733 mL, 3 mmol, 0.10 equiv) was added and the reaction mixture was refluxed for 12 h. The crude product was filtered and the black solids were taken on without further purification (6.02 g, 90% yield): 1H NMR (400 MHz, DMSO-d6) delta 8.79 (d, J = 4.5Hz, 1 H), 8.26 (d, J = 8.1Hz, 1 H), 8.01-7.97 (m, 1 H), 7.92 (d, J = 5.3Hz, 1 H), 7.53 (dd J = 7.2, 4.9Hz, 1H), 7.07(s, 1H), 7.05 (d, J = 5.3Hz, 1 H); LCMS (ESI+) for C12H8N2OS m/z 229 (M + H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 75418-74-5, Methyl 3-oxo-3-(pyridin-2-yl)propanoate.

Reference:
Patent; PFIZER INC.; WO2006/43145; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem