Category: 75449-26-2

On January 9, 2003, Hoegberg, Thomas; Rist, Oystein; Hjelmencrantz, Anders; Moldt, Peter; Elling, Christian E.; Schwartz, Thue W.; Gerlach, Lars Ole; Holst Lange, Birgitte published a patent.Recommanded Product: 75449-26-2 The title of the patent was Metal ion binding-based chemical libraries useful for drug discovery processes. And the patent contained the following:

The invention discloses the use of chem. compounds or selections of chem. compounds (libraries) of the general formula R1XFY(R1)GZR1 [F, G = N, O, S, Se, P; X, Y, Z = (un)branched C1-12 alkyl, (hetero)aryl, etc.; R1 = H, ABC; A = coupling or connecting moiety; B = spacer moiety; C = functional group] for in vivo methods for testing or validating the physiol. importance and/or the therapeutic or pharmacol. potential of biol. target mols., notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biol. target mol. with, notably, a silent, engineered metal ion site. Use of specific metal ion binding sites of a generic nature in specific biol. target mols. such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. The invention provides chem. compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behavior of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal ion chelates). In order to improve the efficacy of the metal ion chelates impact on the biol. target mol. after administration of the metal ion chelate in vivo to a test animal, it is advantageous e.g. to increase the time period during which the metal ion chelate is in the circulatory system and/or localized at the target. Metal ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: 75449-26-2

The Article related to metal chelate library drug discovery, target protein drug discovery metal chelate library, receptor target drug discovery metal chelate library, Pharmacology: Methods and other aspects.Recommanded Product: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1991, Kaczmarek, Lukasz; Nantka-Namirski, Pawel; Klodzinska, Aleksandra; Bujak, Barbara; Tatarczynska, Ewa published an article.Name: [2,2′-Bipyridine]-3,3′-diamine The title of the article was Synthesis and pharmacological properties of some dipyrido[1,3]diazepinones. And the article contained the following:

The synthesis of two isomeric dipyrido[1,3]diazepinones (I and II, R = e.g., Bu, 3-dimethylaminopropyl) and N-monosubstituted derivatives of I by cyclocondensation of corresponding bipyridinediamines with urea was described. The alkylation of these compounds with alkyl halides in K2CO3/DMF/TBAB system gave N,N’-disubstituted compounds Dipyrido[1,3]diazepinones and I showed a weak general depressive action on the central nervous system and they were also devoid of antidepressant, anxiolytic, anticonvulsant and serotoninolytic or serotoninomimetic properties. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Name: [2,2′-Bipyridine]-3,3′-diamine

The Article related to dipyridodiazepinone pharmacol preparation, Pharmacology: Structure-Activity and other aspects.Name: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 18, 2020, Xia, Yanzhi; Long, Xiaojing; Jiang, Zhenjie; Li, Daohao; Ji, Quan; Quan, Fengyu; Wang, Bingbing published a patent.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the patent was Marine organism polysaccharide grafted pyridine organic micromolecule multicolor adjustable aggregation induced luminescent material and preparation method thereof. And the patent contained the following:

The invention relates to polysaccharide grafted pyridine organic micromol., the pyridine mols. are chem. cross-linked through Schiff base reactions to prepare multicolor tunable marine biopolysaccharide materials with aggregation-induced luminescence properties. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to polysaccharide grafted pyridine organic luminescent material, Industrial Carbohydrates: Nonsugars and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 13, 2012, Zhao, Hong-Wu; Li, Hai-Long; Yue, Yuan-Yuan; Qin, Xiao; Sheng, Zhi-Hui; Cui, Jin; Su, Shi; Song, Xiu-Qing; Yan, Hong; Zhong, Ru-Gang published an article.Safety of [2,2′-Bipyridine]-3,3′-diamine The title of the article was Design, synthesis and use of novel 3,3′-disubstituted 2,2′-bipyridine-based chiral ligands: asymmetric catalysis in direct aldol reactions. And the article contained the following:

A wide range of chiral ligands based on the 2,2′-bipyridine scaffold were designed and synthesized. In complexation with metal Lewis acids, the reactivity and stereoselectivity of the prepared chiral ligands were examined in asym. catalytic direct aldol reactions, thus providing the desired products with high stereoselectivities. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Safety of [2,2′-Bipyridine]-3,3′-diamine

The Article related to bipyridine chiral ligand preparation asym aldol catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 13, 2012, Zhao, Hong-Wu; Li, Hai-Long; Yue, Yuan-Yuan; Qin, Xiao; Sheng, Zhi-Hui; Cui, Jin; Su, Shi; Song, Xiu-Qing; Yan, Hong; Zhong, Ru-Gang published an article.Safety of [2,2′-Bipyridine]-3,3′-diamine The title of the article was Design, synthesis and use of novel 3,3′-disubstituted 2,2′-bipyridine-based chiral ligands: asymmetric catalysis in direct aldol reactions. And the article contained the following:

A wide range of chiral ligands based on the 2,2′-bipyridine scaffold were designed and synthesized. In complexation with metal Lewis acids, the reactivity and stereoselectivity of the prepared chiral ligands were examined in asym. catalytic direct aldol reactions, thus providing the desired products with high stereoselectivities. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Safety of [2,2′-Bipyridine]-3,3′-diamine

The Article related to bipyridine chiral ligand preparation asym aldol catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 12, 2019, Wu, Fengshou; Yue, Liangliang; Zhu, Sizhe; Wang, Kai; Sun, Qi published a patent.Quality Control of [2,2′-Bipyridine]-3,3′-diamine The title of the patent was Preparation method of metal ruthenium nano material, and its application as antitumor drug. And the patent contained the following:

The preparation method of metal ruthenium nano material includes (1) preparing metal ruthenium coordination compound by using amino-containing polypyridine ligands (5-amino-1,10-phenanthroline, 2-amino-1,10-phenanthroline, etc.) and ruthenium trichloride, dissolving in citric acid solution, malic acid solution or oxalic acid solution, and ultrasonically dispersing for 10-40 min to obtain mixture A; (2) heating at 140-220°C for 1-5 h to obtain mixture B; (3) adjusting pH to 6.8-7.4 with alk. reagent, dialyzing for 2-48 h, collecting dialyzate, and freeze drying to obtain final product. The metal ruthenium nano material can be used to prepare antitumor drug. The ruthenium nano material has good water solubility, strong light stability, high fluorescence quantum yield, good photodynamic therapy effect for tumors, and good biocompatibility. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Quality Control of [2,2′-Bipyridine]-3,3′-diamine

The Article related to ruthenium nano material preparation antitumor drug, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Quality Control of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hurley, Nicholas J.; Rawson, Jeremy M.; Pilkington, Melanie published an article in 2015, the title of the article was 3,3′-Di(pyrazinamoyl)-2,2′-bipyridine: rational ligand design for the self-assembly of a 1-D coordination polymer.Recommanded Product: 75449-26-2 And the article contains the following content:

A new ligand, 3,3′-di(pyrazinamoyl)-2,2′-bipyridine, L3H2 was prepared and is comprised of distinct binding domains capable of facilitating the formation of coordination polymers. Reaction of L3H2 with [Cu2(OAc)4(H2O)2] in the presence of Et3N·HCl affords {[Cu3(L3)(Cl)(OAc)3]·H2O·MeOH}n (1) in which the [L3]2- anion binds two unique copper ions in a bis-tridentate fashion via amide and pyridyl N atoms. This bimetallic unit is linked to an equivalent unit via a pair of 1,3-acetato and μ-chloro bridges to afford a tetrameric [Cu4(L3)2Cl2(OAc)2] core. Coordination of one of the pyrazole substituents from each ligand to a third copper center of a rigid paddlewheel [Cu2(OAc)4] unit leads to a unique 1-dimensional polymeric structure. Magnetic studies of 1 reveal that the magnetism can be described in terms of two sets of exchange interactions; strong antiferromagnetic interactions between the two copper centers within the paddle-wheel (J/k = -190 K) and a combination of weaker ferro- and antiferro-magnetic interactions within the tetrameric core (J’/k = -5.7 K and J”/k = +2.1 K). The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: 75449-26-2

The Article related to copper bipyridinebisamidopyrazine acetato complex preparation crystal structure magnetism, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Recommanded Product: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2002, Rice, Craig R.; Onions, Stuart; Vidal, Natalia; Wallis, John D.; Senna, Maria-Cristina; Pilkington, Melanie; Stoeckli-Evans, Helen published an article.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the article was The coordination chemistry of 3,3′-diamino-2,2′-bipyridine and its dication: Exploring the role of the amino groups by X-ray crystallography. And the article contained the following:

The synthesis and structural chem. of new divalent transition metal complexes of the bis-bidentate ligand 3,3′-diamino-2,2′-bipyridine (L1) and its dication L1H2 are described. Ligand L1 reacts with salts of divalent transition metals (Cu(II), Mn(II) and Zn) to afford the (1:1) metal-ligand complexes (2a-2d) as well as the tris complexes (3a-3f). All complexes were fully characterized by spectroscopic methods and the following compounds [Cu(L1)Cl2]2 (2a), [Cu(L1)(OAc)2] (2b), [Zn(L1)3][OTf]2 (3a), and [Zn(L1)3][ZnCl4] (3e and 3f) were structurally characterized. Results from single crystal x-ray diffraction measurements indicate that formation of an intramol. H bond between the two amino groups allows the ligand to coordinate divalent metal ions through their diimine binding sites. Also, the structure of compound 2a reveals that it crystallizes as a dimer in which each Cu ion is bound to two pyridine N atoms and two chloride ions in a distorted square planar arrangement, with a long axial contact from a neighboring amino group completing the approx. square-pyramidal geometry at CuII. Complexation of this ligand in acidic conditions afforded [Cu(L1H2)Cl4] (4), as well as the two salts [L1H2][CuCl4] (5a) and [L1H2][ZnCl4] (5b). All three compounds were structurally characterized and the dication (L1H2) displays a different coordination preference for the chelation of metal ions. In all three cases, both of the heterocyclic N atoms of the ligand are protonated, thus preventing chelation to the metal ion, although for compound 4 crystallog. studies reveal that the two amino functionalities coordinate the Cu(II) ion. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to transition metal aminobipyridine preparation structure, crystal structure transition metal aminobipyridine, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 2020, Xu, Guangpeng; Zhang, Yajing; Sun, Jihong; Bai, Shiyang; Zhao, Hongwu published an article.Electric Literature of 75449-26-2 The title of the article was Synthesis of Extended Bipyridine-proline Chiral Catalysts and Resulting Effects on the Asymmetric Aldol Reactions of Bulkier Aldehyde Derivatives with Cyclohexanone. And the article contained the following:

Axially-unfixed 2,2′-bipyridine-based chiral catalysts were synthesized using enantiopure amino acids as chiral sources, which were successfully used in asym. aldol reactions of p-nitrobenzaldehyde with cyclohexanone, while the bulkier aldehyde derivatives (2-naphthaldehyde, 9-anthracenecarboxaldehyde, and 1-pyrenecarboxaldehyde) were selected to further elucidate the catalytic properties. Particularly, the influences of the bipyridine-proline chiral structures and the polarities of used solvents (petroleum ether, toluene, CH2Cl2, ethanol, DMF, DMSO, and water) on the catalytic performance were investigated. The results indicated that the structure of bipyridine catalysts, the mol. volume of aldehydes, and the polarity of solvents have significant effects on the catalytic activities, in which, the smaller steric effects were conducive to the improvement of the yields and stereoselectivities for asym. aldol reaction, along with the increased polarity of used solvents and the decreased mol. volume of aldehydes. Meanwhile, the chem. identity of all compounds was confirmed by 1H-NMR, 13C-NMR, HRMS, and HPLC anal. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to bipyridinyl proline preparation, cyclohexanone aryl aldehyde bipyridinyl proline catalyst diastereoselective aldol reaction, aryl hydroxymethyl cyclohexanone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 3, 2021, Zhang, Huimiao; Toy, Patrick H. published an article.Quality Control of [2,2′-Bipyridine]-3,3′-diamine The title of the article was Halogen Bond-Catalyzed Friedel-Crafts Reactions of Furans Using a 2,2′-Bipyridine-Based Catalyst. And the article contained the following:

A halogen bond donor based on a 2,2′-bipyridine framework I has been synthesized, and used to catalyze Friedel Crafts reactions of furans II (R = H, Me, t-Bu). Electrophiles used successfully in these reactions included various enones such as 3-buten-2-one, crotonophenone, cyclohexenone, etc.; benzaldehyde, and acetic anhydride. The yields of the reactions were generally good using a moderate catalyst loading (0.025 or 0.1 equivalent) at a relatively low temperature (room temperature or 50°C) in acetonitrile. The catalyst was designed with a biaryl scaffold so that if it indeed proved to be an efficient halogen bond donor organocatalyst, an enantioenriched version of it could potentially serve as a stereoselective catalyst. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Quality Control of [2,2′-Bipyridine]-3,3′-diamine

The Article related to furan electrophile friedel craft reaction halogen bond bipyridine catalyst, Heterocyclic Compounds (One Hetero Atom): Furans and other aspects.Quality Control of [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem