Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 757251-62-0, name is 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide
Step 2: Preparation of 1-(4-chloropyridin-2-yl)ethanone. To a solution of 4-chloro-N-methoxy-N-methylpicolinamide (11.25 g, 56.08 mmol) in THF (50 mL) at 0°Cwas added MeMgBr(28.O4mL, 84.12 mmol). The mixture was then stirred at r.t. overnight and quenched withsaturated aqueous NH4C1. The resulting mixture was extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by flash chromatography to give the desired product. ?H NMR (400 MHz, CDC13): 8.52(d, J = 5.2 Hz, 1H), 7.96 (s, 1H), 7.40 (d, J = 5.2 Hz, 1H), 2.64 (s, 3H).LC-MS: mz 156.0 (M+H).
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Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; ZAHLER, Robert; CAI, Zhenwei; ZHOU, Ding; WO2015/3640; (2015); A1;,
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