Category: 7598-35-8

Related Products of 7598-35-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7598-35-8, name is 2-Bromopyridin-4-amine, molecular formula is C5H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[0100] Preparation 6: 3′-fluoro-6′-methyl-2,2′-bipyridin-4-amine[0101] 2-Bromopyridin-4-amine (9 g, 52.0 mmol) and N,N-dimethylpyridin-4-amine (0.636 g, 5.20 mmol) were dissolved in dichloroethane (100 mL) and a solution of phthaloyl dichloride (10.11 ml, 52.0 mmol) in dichloroethylene (20.0 mL) was added dropwise at room temperature. The reaction was stirred for 1 hour and partitioned between saturated bicarbonate and dichloromethane. The organics were separated and dried over Na2S04, filtered, and evaporated to give a solid. The solid was purified by silica columnchromatography in eluting with a gradient of methanol (0-15%) in dichloromethane/ to afford product solid which was triturated with methanol and heated briefly to afford the title compound (4.8g) as an off white solid. 1H NMR (400 MHz, DMSO-d6) ppm 7.69 (dd, J=5.31, 1.77 Hz, 1 H) 7.86 (d, J=1.77 Hz, 1 H) 7.91 – 7.98 (m, 2 H) 7.99 – 8.08 (m, 2 H) 8.57 (d, J=5.56 Hz, 1 H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 7598-35-8, 2-Bromopyridin-4-amine.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KWOK, Lily; LARSON, John David; SABAT, Mark; WO2011/146287; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 7598-35-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7598-35-8, name is 2-Bromopyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Under the protection of nitrogen, 0.69g (4.00mmol) 2-bromo-4-aminopyridine, 1.02g (6.40mmol) 2, 6-difluoro-3-boronic acid pyridine, 0.28g (0.24mmol) Pd (PPh 3) 4 soluble in 25mLTHF aqueous solution, add 10 ml of the mass fraction of 5% of K 2 CO 3 aqueous solution, heating to 70 C reflux state, the stirring reaction 18h. After the natural cooling to room temperature, adding proper amount of distilled water, many times proper amount of ethyl acetate extraction. Combined with the phase, anhydrous MgSO 4 drying. Filtration, filtrate under reduced pressure, the crude product obtained after evaporating solvent. Using ethyl acetate: hexane (v/v) =1 […] 5 as eluant the separation by silica gel column chromatography, to obtain colourless solid product 0.26g, the yield is 63.0%.

According to the analysis of related databases, 7598-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ocean’s king lighting science & technology co. ltd; SHENZHEN OCEAN’S KING LIGHTING SCIENCE & TECHNOLOGY CO., LTD; Zhou, Mingjie; Wang, Ping; Zhang, Juanjuan; Liang, Lusheng; (17 pag.)CN103173209; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 7598-35-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7598-35-8, name is 2-Bromopyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

Et3N (0.64 ml_) and di-tert-butyl dicarbonate (4.62 mmol) at 0 C were added to a solution of commercially available 4-amino-2-bromopyirdine (2.31 mmol, 400 mg) in anhydrous THF (5.9 ml_), and the reaction mixture was stirred overnight at room temperature. The solvent was removed under reduced pressure; then the residue was diluted with EtOAc and sequentially washed with a saturated solution of sodium bicarbonate, water and brine. The organic phase was dried with Na2S04 and concentrated. The crude reaction product was purified by column chromatography over silica gel with a mixture of n- hexane/EtOAc 8:2 as the eluent to afford intermediate O (72% yield). [1H-NMR (CDCIs) d (ppm): 1.52 (s, 9H), 6.68 (bs, 1 H), 7.18 (dd, 1 H, J = 5.6, 2.0 Hz), 7.64 (d, 1 H, J = 1.9 Hz), 8.17 (d, 1 H, J = 5.7 Hz).]

According to the analysis of related databases, 7598-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITA’ DI PISA; CALDERONE, Vincenzo; MINUTOLO, Filippo; TUCCINARDI, Tiziano; TESTAI, Lara; GRANCHI, Carlotta; MARTELLI, Alma; CITI, Valentina; DE LORENZO GARDINAL, Virginia; LENZI, Giulia; LEO, Francesca; MALLOGGI, Giulia; (0 pag.)WO2019/162911; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 7598-35-8, Adding some certain compound to certain chemical reactions, such as: 7598-35-8, name is 2-Bromopyridin-4-amine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7598-35-8.

2-Bromo-5-iodopyridin-4-amine (5); [00192] 4-Amino-2-bromopyridine (22.8g, 131 .8mmole) and sodium acetate (20.8g 254mmole) were stirred in acetic acid (82ml_) and a solution of iodine monochloride (1 M in acetic acid, 134ml_, 134 mmole) was added. The mixture was stirred and heated at 75C for 3 hours. Most of the acetic acid was evaporated and the residue was partitioned between water (500ml_) and ethyl acetate (550ml_). The aqueous was again extracted with ethyl acetate (300ml_) The combined extracts were washed twice with 10% sodium carbonate solution (600, 300ml_), with 10% sodium thiosulfate solution (200ml_), with water and with brine, then dried and evaporated. This gave 40.3g of a crude product mix. This was combined with the crude product from a reaction on 7.5g of 4-amino-2- bromopyridine for purification. A large silica column (9cm internal diameter with 28cm bed of silica) was prepared in 5% ethyl acetate in dichloromethane. The crude material was applied in the same solvent. The column was eluted with 5% ethyl acetate in dichloromethane, with 10% ethyl acetate in dichloromethane and with 20% ethyl acetate in dichloromethane to give the desired isomer 5 (20.2g, 38%): 1 H-NMR (CDCI3, 500MHz): delta 4.74 (br s, 2H, NH2), 6.80 (s, 1 H), 8.34 (s, 1 H); and subsequently with 1 :1 ethyl acetate:dichloromethane to give 6 undesired isomer: 2-bromo-3-iodopyridin-4- amine 6 (19.3g, 37%).

According to the analysis of related databases, 7598-35-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BAVETSIAS, Vassilios; ATRASH, Butrus; NAUD, Sebastien Gaston Andre; SHELDRAKE, Peter William; BLAGG, Julian; WO2012/123745; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 7598-35-8, Adding some certain compound to certain chemical reactions, such as: 7598-35-8, name is 2-Bromopyridin-4-amine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7598-35-8.

2.8 g (32.2 mmol, 2 eq) of pyruvic acid (initial product 1 ) were poured into a 50 mL single collar flask, 20 mL of thionyl was added to this and it was heated at reflux for 2 hours. After 2 hours, the reaction mixture was dry concentrated by azeotroping several times with dry toluene. 2.8 g (16.1 mmol, 1 eq) of 2-bromo-pyridin-4-ylamine (initial product 2), diluted in 5 mL of pyridine, was then added, drop-by-drop at 0C, and the mixture agitated at ambient temperature for 16 hours. The reaction mixture was diluted with 50 mL of ethyl acetate, washed with 50 mL of an aqueous solution of saturated sodiumbicarbonate, followed by 3 x 50 mL of water. The organic phase was dry concentrated. The residue was chromatographed on silica with a heptanes / ethyl acetate mixture (2/1 v/v) as eluent. N-(2-bromo-pyridin-4-yl)-2-oxo-propionamide was obtained in the form of a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7598-35-8, 2-Bromopyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALDERMA RESEARCH & DEVELOPMENT; POINSARD, Cedric; WO2013/64681; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7598-35-8, name is 2-Bromopyridin-4-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.HPLC of Formula: C5H5BrN2

To a 3-necked round-bottom flask containing 2-bromopyridin-4-amine (100 g, 578 mmol), acetic acid (1 L) and sodium acetate (118 g, 1.44 mol) was added a solution of iodine monochloride (103 g, 635 mmol) in acetic acid (0.5 L) dropwise with stirring at 50 C. The resulting solution was stirred for 3 h at 75 C. The reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting solution was diluted with brine (1 L) and extracted with EtOAc (3 x 1 L). The combined organic layers were washed with saturated aqueous sodium bicarbonate (2 x 0.5 L), saturated aqueous sodium sulfite (0.2 L), and brine (0.3 L), dried over anhydrous sodium sulfate and concentrated in vacuo. The crude product was purified via flash chromatography on silica gel (eluent: 5% EtOAc in dichloromethane) to afford 2-bromo-5-iodopyridin-4-amine (50 g, 29%) as a white solid. LCMS (ESI): RT (min) = 1.114, [M+H]+ = 299, method = L.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7598-35-8, 2-Bromopyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; GENENTECH, INC.; BRYAN, Marian C.; CHAN, Bryan; DIEDERICH, Francois; DOTSON, Jennafer; HANAN, Emily; HEFFRON, Timothy; LAINCHBURY, Michael; HEALD, Robert; SEWARD, Eileen M.; WO2014/210354; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7598-35-8, name is 2-Bromopyridin-4-amine, the common compound, a new synthetic route is introduced below. COA of Formula: C5H5BrN2

A 50 mL single necked round bottom flask equipped with reflux condenser, under nitrogen atmosphere, was charged with 2-bromopyridin-4-amine (17) (5.0 g, 28.9 mmol, 1.0 equiv), NaOAc.3H2O (5.90 g, 43.3 mmol, 1.5 equiv), ICl (5.16 g, 31.8 mmol, 1.1 equiv) and glacial acetic acid (19.3 mL) and stirred, at 70 oC, for 16 hours. The reaction mixture was cooled and transferred to a separating funnel and was carefully quenched with portionwise addition of solid powdered NaHCO3 (31.1 g), water (50 mL) and EtOAc (50 mL). The layers were then separated and the aqueous layer was extracted with EtOAc (3 x 50 mL). The combined organic layers were dried over MgSO4 and the volatiles were evaporated. The residue was purified by portionwise flash column chromatography over silica using n-hexane/ EtOAc (99:1 to 50:50) mixtures as eluent to give 2-bromo-5-iodopyridin-4-amine 18 as a light brown solid (3.70 g, 43%). A sample of which had 1H NMR spectral data and low resolution GC/MS (EI) mass spectral data identical to those in the literature

The synthetic route of 7598-35-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Balfour, Michael N.; Zukerman-Schpector, Julio; Rodriguez, Maria Jose Davila; Reis, Joel Savi; Esteves, Carlos Henrique A.; Stefani, Helio A.; Synthetic Communications; vol. 49; 3; (2019); p. 351 – 358;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 7598-35-8 ,Some common heterocyclic compound, 7598-35-8, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 2-bromopyridin-4-amine (LVIII) (584 g, 3.38 mol, 1 eq) and sodium acetate (554 g, 6.75 mol, 2 eq) in HOAc (2000 mL) was added a solution of iodine monochloride (559 g, 3.44 mol, 176 mL, 1.02 eq) in HOAc (1000 mL) drop-wise at 70 C., the resulting mixture was stirred at 70 C. for 3 h. The mixture was concentrated to remove HOAc and poured into water (20 L). The aqueous solution was extracted with EtOAc (10 L*3). The combined organic layers were washed with saturated aq. Na2CO3 (20 L), saturated aq. Na2S2O3 (10 L), brine (10 L), dried over Na2SO4, filtered and concentrated to give a yellow residue, which was purified by column chromatography (1:1?1:0 petroleum ether:DCM) to obtain 2-bromo-5-iodopyridin-4-amine (II) as a yellow solid (340 g, 1.14 mol, 33.7% yield). H NMR (400 MHz, DMSO-d6) delta ppm 6.56-6.53 (3H, m), 7.73-7.72 (1H, d, J=5.2 Hz); ESIMS found for C5H4BrIN2 m/z 299.9 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7598-35-8, 2-Bromopyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Cao, Jianguo; Bollu, Venkataiah; Chiruta, Chandramouli; Mittapalli, Gopi Kumar; Eastman, Brian Walter; Hofilena, Brian Joseph; (960 pag.)US2019/127370; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 7598-35-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 7598-35-8, name is 2-Bromopyridin-4-amine. A new synthetic method of this compound is introduced below.

To a solution of 2-bromopyridin-4-amine (75 g, 433 mmol) in pyridine (750 mL) stirred under nitrogenat 0C was added 2,5-dichloropyridine-3-sulfonyl chloride (128 g, 520 mmol) portionwise. The reactionmixture was stirred at room temperature for 16 h. After this time, pyridine was evaporated under reduced pressure to obtain a crude residue which was poured into ice water. The resulting solid was collected by filtration and dried. The solid was dissolved in EtOAc (2 L) and the organic layer was washed with 10% EDTA solution (2 L). The organic phase was dried over Na2SO4, filtered andconcentrated under reduced pressure to afford the title compound (120 g) as a brown solid. LCMS (Method G) Rt = 2.16 mi [M+H] = 381.9/383.9/385.9.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,7598-35-8, 2-Bromopyridin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; ANDERSON, Niall Andrew; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CANNONS, Edward Paul; COOPER, Anthony William James; DOWN, Kenneth David; DOYLE, Kevin James; HAMBLIN, Julie Nicole; INGLIS, Graham George Adam; LE GALL, Armelle; PATEL, Vipulkumar Kantibhai; PEACE, Simon; SHARPE, Andrew; WHITE, Gemma Victoria; (157 pag.)WO2017/137535; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In an article, author is Liu, Yan-Yun, once mentioned the application of 7598-35-8, Safety of 2-Bromopyridin-4-amine, Name is 2-Bromopyridin-4-amine, molecular formula is C5H5BrN2, molecular weight is 173.01, MDL number is MFCD01646061, category is pyridine-derivatives. Now introduce a scientific discovery about this category.

Mild and efficient copper-catalyzed oxidative cyclization of oximes with 2-aminobenzyl alcohols at room temperature: synthesis of polysubstituted quinolines

A simple and efficient ligand-free Cu-catalyzed protocol for the synthesis of polysubstituted quinolines via oxidative cyclization of oxime acetates with 2-aminobenzyl alcohols at room temperature has been developed. The presented approach provides a new synthetic pathway leading to polysubstituted quinolines with good functional group tolerance under mild conditions. Moreover, this transformation can be applied for the preparation of quinolines on a gram scale. Oxime acetates serve as the internal oxidants in the reactions, thus making this method very attractive.

If you are interested in 7598-35-8, you can contact me at any time and look forward to more communication. Safety of 2-Bromopyridin-4-amine.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem