Category: 76005-99-7

Reference of 76005-99-7 ,Some common heterocyclic compound, 76005-99-7, molecular formula is C7H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

D) Preparation of 2-Chloro-N-(2-methoxy-4-methyl-3-pyridinyl)-3-pyridinecarboxamide STR15 To a solution of 0.4 g (2.9 mmol) of 3-amino-2-methoxy-4-methylpyridine and 0.5 g (2.9 mmol) of 2-chloronicotinoyl chloride in EtOAc at 0 C. was added 0.4 g (3.0 mmol) of N,N-diisopropylethylamine. Stirring was continued for 10 h at which point the mixture was washed with 0.1N HCl, dried (MgSO4), concentrated and purified by flash chromatography on silica gel (1:1 EtOAc:hexanes) to yield 0.7 g (88%) of the desired material. m.p.: 145-146 C. (Recrystallized from ethyl acetate).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76005-99-7, 2-Methoxy-4-methylpyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US5532358; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 76005-99-7 ,Some common heterocyclic compound, 76005-99-7, molecular formula is C7H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

D) Preparation of 2-Chloro-N-(2-methoxy-4-methyl-3-pyridinyl)-3-pyridinecarboxamide STR15 To a solution of 0.4 g (2.9 mmol) of 3-amino-2-methoxy-4-methylpyridine and 0.5 g (2.9 mmol) of 2-chloronicotinoyl chloride in EtOAc at 0 C. was added 0.4 g (3.0 mmol) of N,N-diisopropylethylamine. Stirring was continued for 10 h at which point the mixture was washed with 0.1N HCl, dried (MgSO4), concentrated and purified by flash chromatography on silica gel (1:1 EtOAc:hexanes) to yield 0.7 g (88%) of the desired material. m.p.: 145-146 C. (Recrystallized from ethyl acetate).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76005-99-7, 2-Methoxy-4-methylpyridin-3-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; US5532358; (1996); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76005-99-7, name is 2-Methoxy-4-methylpyridin-3-amine, molecular formula is C7H10N2O, molecular weight is 138.1671, as common compound, the synthetic route is as follows.Recommanded Product: 2-Methoxy-4-methylpyridin-3-amine

(2) 29.4 g of Compound 2 was dissolved in 600 mL of DCM in a 2 L three-necked flask, and 25.0 g of AcOK potassium acetate was added at 0 C., and 43.4 g of Ac2O; about 40min drops completed, adding 11.25g18-crown ether, maintaining the temperature 0 C, 54.9g of isoamyl nitrite is dripped, about 40min drops completed, the natural return to room temperature.After the system has returned to room temperature, it is heated to 65 degrees reflux overnight (about 12 hours).The next day the TLC test material disappeared, NaHCO3The saturated solution was adjusted to pH = 6, the organic phase was separated, the aqueous phase was extracted once with DCM, the organic phases were combined and dried to dryness, then K2CO3The residue was spin-dried with methanol for about 1 h, filtered and spun dry. The dried residue was then treated with EA and saturated brine. The organic phase was dried to give compound 3 (crude) 29 g, 91.3% yield, which was used directly in Next step.TLC information: Raw Rf = 0.8, Product Rf = 0.5.Developing agent: PE: EA = 1: 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,76005-99-7, 2-Methoxy-4-methylpyridin-3-amine, and friends who are interested can also refer to it.

Reference:
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (7 pag.)CN104230811; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76005-99-7, name is 2-Methoxy-4-methylpyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 76005-99-7

(2) 29.4 g of Compound 2 was dissolved in 600 mL of dichloromethane, 25.0 g of potassium acetate was added,Then, the temperature was lowered to 0 C, 43.4 g of acetic anhydride was slowly added dropwise,After about 40 min, 11.25 g of 18-crown-6 ether was added,After the completion of dropping, 54.9 g of isoamyl nitrite was slowly added dropwise at 0 C, and the temperature was returned to room temperature, and the temperature was raised to 65 C and refluxed overnight. After about 12 h, the reaction mixture was adjusted to pH 6 with saturated sodium hydrogencarbonate solution,The organic phase was separated,The aqueous phase was again extracted once with dichloromethane,The combined organic phase was dried and concentrated.Methanol and potassium carbonate were added to the residue, and the mixture was stirred at room temperature for 1 h. After the reaction was complete, the system was filtered off and dried, and the residue was dissolved in ethyl acetate.Saturated sodium chloride solution, and concentrated to dryness to obtain 29 g of the crude product (Compound 3) in a yield of 91.3%. TLC information (petroleum ether: ethyl acetate = 1: 1): starting material Rf = 0.8, product Rf = 0.5.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 76005-99-7, 2-Methoxy-4-methylpyridin-3-amine.

Reference:
Patent; Sphinx Scientific Laboratory Corporation; Yao, Qingjia; Xu, Yangjun; Wu, Simin; (6 pag.)CN103992318; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem