Category: 76015-11-7

Application of 76015-11-7 ,Some common heterocyclic compound, 76015-11-7, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a 2-Methyl-3-methoxy-4-chloropyridine N-oxide 11.2 g (80.5 mmol) of 3-methoxy-2-methyl-4(1H)-pyridone were heated under reflux for 10 hours in 100 ml of phosphorus oxychloride. Subsequently, the mixture was concentrated and 30 ml of toluene were added to each 2 ml volume; concentration then took place once again and the residue was taken up in 150 ml of water, with the pH of the mixture then being adjusted to 11 with K2 CO3; this mixture was then extracted with dichloromethane and the organic phase was washed with water, dried and freed from solvent. 8 g of the product were obtained, under standard conditions, from the pale brown oil (9 g) using m-chloroperbenzoic acid in dichloromethane, m.p. 88-89 C. (from petroleum ether).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76015-11-7, its application will become more common.

Reference:
Patent; Hoechst Aktiengesellschaft; US5658933; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 76015-11-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 76015-11-7, name is 3-Methoxy-2-methylpyridin-4(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

In a four-necked flask equipped with a mechanical stirrer, a reflux condenser, and a thermometer,230 grams of phosphorus oxychloride, 27.8 grams of 3-methoxy-2-methyl-4-pyrone, stirring slowly heated to 60-70 C, heat 10h,Cooling to 0-10 C, adding 60 g DMF, stirring 2h, layered,The lower organic layer was collected to give Vilsmeier reagent.The upper layer was poured into 50 g of ice-water mixture and the hydrolysis temperature was controlled at -5-5 C.Stirring 1h hydrolysis is complete, with 30% liquid alkali 20-30 adjust the pH to 12,Extracted with methylene chloride,Distillation gave the desired product4-Chloro-3-methoxy-2-methyl-4-pyridin 26.5 g,Using 3-methoxy-2-methyl-4-pyrone meter, mass yield of 95.3%.

According to the analysis of related databases, 76015-11-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; jiangsu yuxiang chemical co. ltd; Zhejiang University of Science and Technology; LI, GUONENG; Zhang, ZHIGUO; Cheng, Yun Tao; Zhong, Xu Hui; Li, Qing Long; Cheng, hongweid; (7 pag.)CN103483248; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 76015-11-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76015-11-7, name is 3-Methoxy-2-methylpyridin-4(1H)-one. A new synthetic method of this compound is introduced below.

3-Methoxy-2-methyl-4(1H)-pyridone (27.8g, 0.2 mol) was added to phosphorus oxychloride (200 mL) and the resulting mixture was heated under nitrogen at 90 oC for 18 h. The homogeneousmixture was cooled to 20 oC and concentrated under reduced pressure.The residue was dissolved in ice-water. Adjustment of the solution to pH 12with 40% sodium hydroxideresulted in a turbid suspension which was extracted with dichloromethane (3 x100 mL). The combined organic extracts were combined, washed with water. After drying the extract with MgSO4,the DCM was removed by rotary evaporation to give the title product (30.2 g,96%). 1H NMR (CDCl3) d 8.14(d, 1H, J = 5.32 Hz), 7.17 (d, 1H, J = 5.10 Hz), 3.85 (s, 3H), 2.54 (s, 3H). m/z (ESI) 157.91 (M+ +1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76015-11-7, its application will become more common.

Reference:
Article; Maharvi, Ghulam M.; Bharucha, Adil E.; Fauq, Abdul H.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 9; (2013); p. 2808 – 2811;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 76015-11-7 ,Some common heterocyclic compound, 76015-11-7, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

REFERENCE EXAMPLE 2 3-Methoxy-2-methyl-4(1H)-pyridone (5.6 g) was suspended in phosphorus oxychloride (50 ml), refluxed for 10 hours, and concentrated. To the resultant residue was added toluene and the residual phosphorus oxychloride was evaporated under reduced pressure. To the resultant oily substance were added chloroform and water and the chloroform layer was separated. The aqueous layer was made alkaline with potassium carbonate and extracted with chloroform. The chloroform solutions thus obtained were combined, washed with water, dried, and evaporated. The residue was purified by column chromatography on silica gel, to give 4-chloro-3-methoxy-2-methylpyridine (4.8 g) as a light brown oil. NMR(CDCl3) delta: 2.53(3H, s), 3.84(3H, s), 7.14(1H, d, J=6 Hz), 8.12(1H, d, J=6 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76015-11-7, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US4738975; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 76015-11-7 ,Some common heterocyclic compound, 76015-11-7, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example 2 3-Methoxy-2-methyl-4(1H)-pyridone (5.6 g) was suspended in phosphorus oxychloride (50 ml), refluxed for 10 hours, and concentrated. To the resultant residue was added toluene and the residual phosphorus oxychloride was evaporated under reduced pressure. To the resultant oily substance were added chloroform and water and the chloroform layer was separated. The aqueous layer was made alkaline with potassium carbonate and extracted with chloroform. The chloroform solutions thus obtained were combined, washed with water, dried, and evaporated. The residue was purified by column chromatography on silica gel, to give 4-chloro-3-methoxy-2-methylpyridine (4.8 g) as a light brown oil. NMR(CDCl3)delta:2.53 (3H,s), 3.84(3H,s), 7.14(1H,d,J=6Hz), 8.12 (1H,d,J=6Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76015-11-7, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP208452; (1991); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem