Reference of 760207-87-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 760207-87-2, name is 5-Bromo-2-methoxy-3-methylpyridine. A new synthetic method of this compound is introduced below.
5-bromo-3-(bromomethyl)-2-methoxypyridine To a solution of 5-bromo-2-methoxy-3-methylpyridine (Ark, 2.981 g, 14.75 mmol) in CCl4 (12 mL) was added N-bromosuccinimide (2.89 g, 16.23 mmol) and (E)-2,2′-(diazene-1,2-diyl)bis(2-methylpropanenitrile) (0.036 g, 0.221 mmol). The reaction mixture was stirred at 80 C. for 2 hours, cooled in an ice bath, and filtered through diatomaceous earth. The solution was concentrated in vacuo to afford the title compound (2.0538 g, 50% yield). 1H NMR (501 MHz, CDCl3) delta ppm 8.17 (d, J=2.4 Hz, 1H), 7.74 (d, J=2.4, 1H), 4.43 (s, 2H), 4.01 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,760207-87-2, its application will become more common.
Reference:
Patent; AbbVie S.a.r.l.; Galapagos NV; Altenbach, Robert J.; Bogdan, Andrew; Desroy, Nicolas; Gfesser, Gregory A.; Greszler, Stephen N.; Koenig, John R.; Kym, Philip R.; Liu, Bo; Scanio, Marc J.; Searle, Xenia; Wang, Xueqing; Yeung, Ming C.; Zhao, Gang; (247 pag.)US2018/99932; (2018); A1;,
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