Category: 76041-72-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76041-72-0, name is 5-(Trifluoromethyl)pyridine-2(1H)-thione. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

Production Example 1-4 Production of Compound Represented by Formula (1-4) Production of Compound Represented by Formula 9-2 10 g of the compound represented by Formula (10-2) and 30 ml of tetrahydrofuran were mixed at room temperature, followed by stirring, then, the obtained mixture was cooled to 0 C., and 4.0 g of 95% acrolein and 0.1 g of triethylamine were added dropwise thereto. The obtained mixture was stirred for 1.5 hours under ice-cooling. Next, water was added to the obtained mixture. The obtained mixture was extracted with tert-butyl methyl ether. The organic layer was washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure, whereby 13 g of the compound represented by Formula (9-2) was obtained. 1H NMR (CDCl3) delta ppm: 9.80 (1H, s), 8.67-8.66 (1H, m), 7.67 (1H, dd), 7.26 (1H, dd), 3.48 (2H, ddd), 2.98-2.95 (2H, m)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 76041-72-0, 5-(Trifluoromethyl)pyridine-2(1H)-thione.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; Jin, Yoshinobu; Fujino, Yoshimi; US2015/289505; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 76041-72-0 ,Some common heterocyclic compound, 76041-72-0, molecular formula is C6H4F3NS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediates 4: a) 5-Trifluoromethyl-pyridine-2-sulfonyl chloride (4a); 0.8 g (4.47 mmol) of 5-trifluoromethyl-pyridine-2-thiol is placed at -8C in 16 m L of H2S04. 16.96 mL (35.7 mmol) of a 13% sodium hypochlorite solution is poured gently such that the temperature of the reaction medium does not exceed 5C. This mixture is then stirred for 45 min, taken up by water and then extracted using AcOEt. After drying followed by reduction to dryness of the organic phases, an oil is isolated (yield: 79%) and used as such for the next reactions.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76041-72-0, its application will become more common.

Reference:
Patent; PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; LE ROY, Isabelle; PIGNIER, Christophe; WO2012/69503; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem