Category: 76041-79-7

Application of 76041-79-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, molecular formula is C6H3BrF3NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 5-Bromo-1-neopentyl-3-(trifluoromethyl)pyridin-2(1 – )-one (P45)To a solution of compound P45a (10.0 g, 41.3 mmol) in DMF (130 mL) was added portionwise NaH (4.1 g, 103 mmol) at 0C. After stirring for 40 min, 1-bromo-2,2-dimethyl-propane (18.7 g, 124 mmol) was added and the solution was stirred at 100C overnight, diluted with water and extracted with EA twice. The combined organic layers were washed with water and brine consecutively (3 x), dried over Na2S04, filtered, concentrated and purified by CC (PE/EA = 5/1) to give compound P45 (1.4 g, 11%) as a yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 76041-79-7, 5-Bromo-3-(trifluoromethyl)pyridin-2-ol.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 76041-79-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, molecular formula is C6H3BrF3NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: 5-Bromo-1-neopentyl-3-(trifluoromethyl)pyridin-2(1 – )-one (P45)To a solution of compound P45a (10.0 g, 41.3 mmol) in DMF (130 mL) was added portionwise NaH (4.1 g, 103 mmol) at 0C. After stirring for 40 min, 1-bromo-2,2-dimethyl-propane (18.7 g, 124 mmol) was added and the solution was stirred at 100C overnight, diluted with water and extracted with EA twice. The combined organic layers were washed with water and brine consecutively (3 x), dried over Na2S04, filtered, concentrated and purified by CC (PE/EA = 5/1) to give compound P45 (1.4 g, 11%) as a yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 76041-79-7, 5-Bromo-3-(trifluoromethyl)pyridin-2-ol.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3BrF3NO

To a solution of 5-bromo-3-(trifluoromethyl)-2(1H)-pyridinone (D16) (2 g) and silver carbonate (6.84 g) in toluene (25 mL) stirred in air at room temperature was added 2-iodopropane (5.79 mL) dropwise. The reaction mixture was stirred at room temperature for 1 day. The reaction mixture was filtered and the filtrate was concentrated, the residue was purified by column chromatography to give 5-bromo-2-[(1-methylethyl)oxy]-3-(trifluoromethyl)pyridine (D17) (1.2 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 76041-79-7, 5-Bromo-3-(trifluoromethyl)pyridin-2-ol.

Reference:
Patent; GLAXO GROUP LIMITED; Lin, Xichen; Ren, Feng; Zhang, Haibo; US2013/12491; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C6H3BrF3NO

To a solution of 5-bromo-3-(trifluoromethyl)-2(1H)-pyridinone (D16) (2 g) and silver carbonate (6.84 g) in toluene (25 mL) stirred in air at room temperature was added 2-iodopropane (5.79 mL) dropwise. The reaction mixture was stirred at room temperature for 1 day. The reaction mixture was filtered and the filtrate was concentrated, the residue was purified by column chromatography to give 5-bromo-2-[(1-methylethyl)oxy]-3-(trifluoromethyl)pyridine (D17) (1.2 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 76041-79-7, 5-Bromo-3-(trifluoromethyl)pyridin-2-ol.

Reference:
Patent; GLAXO GROUP LIMITED; Lin, Xichen; Ren, Feng; Zhang, Haibo; US2013/12491; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 76041-79-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, molecular formula is C6H3BrF3NO, molecular weight is 241.99, as common compound, the synthetic route is as follows.

Methyl iodide (0.12 mL, 1.88 mmol) and Cs2C03(0.942 g, 2.89 mmol) were added to a solution of 5-bromo-3-(trifluoromethyl)-1 H-pyridin-2-one (0.350 g, 1.45 mmol) in DMF (3 mL) and the resulting mixture was stirred for 18 h at rt. The solvent was evaporated under reduced pressure, water (10 ml) was added to the residue and the aqueous phase was extracted with EtOAc (2 x 30 mL). The combined organic phases were washed with brine and dried over MgS04, filtered and concentrated under reduced pressure. The material was triturated with ether then dried to afford title compound, which was used in the next step without any further purification (0.32 g, 86%).1H NMR (500 MHz, CDCI3) delta 7.78 (d, J = 2.1 Hz, 1 H), 7.64 (d, J = 2.7 Hz, 1 H), 3.59 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 76041-79-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NEOMED INSTITUTE; POURASHRAF, Mehrnaz; JACQUEMOT, Guillaume; CLARIDGE, Stephen; BAYRAKDARIAN, Malken; JOHNSTONE, Shawn; ALBERT, Jeffrey S.; GRIFFIN, Andrew; (180 pag.)WO2017/24412; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 76041-79-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, molecular formula is C6H3BrF3NO, molecular weight is 241.99, as common compound, the synthetic route is as follows.

Methyl iodide (0.12 mL, 1.88 mmol) and Cs2C03(0.942 g, 2.89 mmol) were added to a solution of 5-bromo-3-(trifluoromethyl)-1 H-pyridin-2-one (0.350 g, 1.45 mmol) in DMF (3 mL) and the resulting mixture was stirred for 18 h at rt. The solvent was evaporated under reduced pressure, water (10 ml) was added to the residue and the aqueous phase was extracted with EtOAc (2 x 30 mL). The combined organic phases were washed with brine and dried over MgS04, filtered and concentrated under reduced pressure. The material was triturated with ether then dried to afford title compound, which was used in the next step without any further purification (0.32 g, 86%).1H NMR (500 MHz, CDCI3) delta 7.78 (d, J = 2.1 Hz, 1 H), 7.64 (d, J = 2.7 Hz, 1 H), 3.59 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 76041-79-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NEOMED INSTITUTE; POURASHRAF, Mehrnaz; JACQUEMOT, Guillaume; CLARIDGE, Stephen; BAYRAKDARIAN, Malken; JOHNSTONE, Shawn; ALBERT, Jeffrey S.; GRIFFIN, Andrew; (180 pag.)WO2017/24412; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 76041-79-7, name is 5-Bromo-3-(trifluoromethyl)pyridin-2-ol, the common compound, a new synthetic route is introduced below. HPLC of Formula: C6H3BrF3NO

Step 1 : 5-Bromo-2-chloro-3-(trifluoromethv0pyridine (P46a)A solution of compound P45a (11.0 g, 45.8 mmol) in phenylphosphonicdichloride (22 mL) was heated at 140C overnight, cooled to rt, poured into ice water and extracted with EA. The organic layer was washed with sat. aq. NaHC03 and brine consecutively, dried over NaS04, filtered, concentrated and purified by CC (PE/EA = 5/1) to give compound P46a (10.5 g, 88%) as a yellow liquid.

The synthetic route of 76041-79-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas; WO2012/139775; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem