10 Sep 2021 News The origin of a common compound about 766-16-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,766-16-5, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 766-16-5, 4-Fluoro-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 766-16-5, blongs to pyridine-derivatives compound. Computed Properties of C6H6FN

INTERMEDIATE 19 4-(3 -Iodo- 1 H-p yrazol- 1 – ylV 2-methylpyridine To a stirred solution of 4-fluoro-2-methylpyridine (1 g, 9.0 mmol) and 3-iodo-lH- pyrazole (1.76 g, 9.1 mmol) in DMSO was added NaH ( 60% in oil, 0.45 g, 11.25 mmol) in portion at 0 C. The mixture was stirred at room temparature for 30 min or until bubbling ceased, then warmed to 90 C and stirred at 90 C for 4 h. The reaction mixture was cooled to room temperature, partitioned between EtOAc and water. The aqueous was extracted with EtOAc three times. The organic phases were combined, dried over Na2S04 and concentrated in vacuo to give the crude product. This was purified by flash chromatography (Isco CombiFlash, 120 g Silica gel column, 0-100% EtOAc in hexanes) to afford 4-(3-iodo-lH-pyrazol-l-yl)-2-methylpyridine. LCMS calc. = 285.98; found = 285.92 (M+H)+. NMR (500 MHz, CDC13): delta 8.57 (br s, 1 H); 7.87 (br s, 1 H); 7.56 (br s, 1 H); 7.35 (br s, 1 H); 6.71 (br s, 1 H); 2.66 (s, 3 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,766-16-5, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MOCHIDA PHARMACEUTICAL CO., LTD.; SMITH, Cameron, James; TAN, John, Qiang; ZHANG, Ting; BALKOVEC, James; GREENLEE, William, John; GUO, Liangqin; XU, Jiayi; CHEN, Yi-heng; CHEN, Yili; CHACKALAMANNIL, Samuel; HIRABAYASHI, Tomokazu; NAGASUE, Hiroshi; OGAWA, Kouki; WO2014/120346; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 4-Fluoro-2-methylpyridine

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 766-16-5, 4-Fluoro-2-methylpyridine, other downstream synthetic routes, hurry up and to see.

Related Products of 766-16-5, Adding some certain compound to certain chemical reactions, such as: 766-16-5, name is 4-Fluoro-2-methylpyridine,molecular formula is C6H6FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-16-5.

4-Fluoro-2-methylpyridine(4.32 g, 4.01 mL, 38.9 mmol), NBS (6 g, 33.7 mmol) and AIBN(0.56 g, 3.4 mmol) were mixed and CCl 4 (50 mL) was added, followed by heating to 80 C. for 3 h. After cooling the reaction mixture with diatomaceous earthThe filtrate was concentrated under reduced pressure and the crude product was purified by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 9/1) to giveTo 1.3 g of product as a brown oil, yield: 16%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 766-16-5, 4-Fluoro-2-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 4-Fluoro-2-methylpyridine

According to the analysis of related databases, 766-16-5, the application of this compound in the production field has become more and more popular.

Related Products of 766-16-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 766-16-5, name is 4-Fluoro-2-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of l-cyclopropyl-6-(lH-imidazol-4-yl)-3,3-dimethyl-lH-pyrrolo[3,2-c]pyridin- 2(3H)-one (80 mg), 4-fluoro-2-methylpyridine (42 mg) and cesium carbonate (185 mg) in acetonitrile (1 ml) was heated to reflux temperature for 3 h. The mixture was evaporated and the residue purified by flash chromatography (silica gel, 0% to 10% MeOH in dichloromethane) to give the title compound (59 mg, 55%) as a white foam. MS (ESI, m/z): 360.3 [(M+H)+].

According to the analysis of related databases, 766-16-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HILPERT, Hans; KOLCZEWSKI, Sabine; LIMBERG, Anja; STOLL, Theodor; WO2015/177110; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem