Category: 769-28-8

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile, molecular formula is C8H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile (10.0 g, 67.5 mmol) in MeOH (1.50 L) and conc. HCl (30 mL) was added 10% Pd(OH)2 (19 g) under N2 atmosphere. The N2 gas was displaced by H2 gas and the mixture was stirred for 26 hours at RT under hydrogen atmosphere. The H2 gas was displaced by N2 gas. The mixture was filtered through Celite, washed with MeOH and concentrated. The residue was triturated with EtOH, collected with Buchner funnel, and dried under vacuum pressure to give the titled compound as a white solid (11.5 g, 90%). 1H NMR (400 MHz, DMSO-d6): delta ppm 11.86 (brs, 1H), 5.98 (s, 1H), 3.78 (m, 2H), 2.20 (s, 3H), 2.16 (s, 3H).

With the rapid development of chemical substances, we look forward to future research findings about 769-28-8.

Reference:
Patent; Kuntz, Kevin Wayne; Campbell, John Emmerson; Seki, Masashi; US2014/107122; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 769-28-8 , The common heterocyclic compound, 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The titledproduct was obtained from carbonitrile B7c according to the general procedure describedpreviously for the reduction reaction of carbonitrile as a light yellow solid (6.3 g). The crude product was dissolved with menthol in ice bath below 0 C, the 4 N hydrogenchloride ethanol solution (20 mL) was added dropwise. The stirring was continued for 60min, and the solid filtered off and washed with ethanol. After drying, hydrochloride saltwas obtained as a white solid (5.0 g, 97%). 1H NMR (600 MHz, DMSO-d6) delta (ppm): 11.84(br, 1H), 8.04 (s, 3H), 5.97 (s, 1H), 3.77 (s, 2H), 2.21 (s, 3H), 2.16 (s, 3H). Compounds B1~B5were obtained from different carbonitrile (B6a-c, B7a-b) to provide the correspondingproducts according to the general procedure described previously for the reductionreaction of carbonitrile.

The synthetic route of 769-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Guoliang; Du, Fangyu; Sun, Wenjiao; Wang, Lihui; Wu, Chunfu; Yang, Cheng; Zhou, Qifan; Molecules; vol. 25; 9; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H8N2O

Add 5.0g (0.034mol) to a 500mL single-mouth bottle4,6-dimethyl-3-cyanopyrimidin-2-one,250mL of methanol, not fully soluble,25mL 25% ammonia water,About 5.0g of nickel, replaced by argon three times,The hydrogen was replaced three times, and the temperature was raised to 50 C. After 11 h of reaction, the TLC reaction was complete.Stop the reaction and filter the solution through diatomaceous earth.The filtrate was evaporated to dryness to give 6.3 g, m.Dissolve the product with methanol,Placed in an ice salt bath,20mL of 4N hydrochloric acid ethanol solution was added dropwise with stirring.After the drop,After stirring for 1 h in an ice bath, a large amount of white solid was precipitated, which was filtered with suction to give a white solid.Wash twice with ethanol, suction filtration,Dry to give 5.0 g of a white solid.The yield was 96.9%.

With the rapid development of chemical substances, we look forward to future research findings about 769-28-8.

Reference:
Patent; Shenyang Pharmaceutical University; Chen Guoliang; Wang Lihui; Zhou Qifan; Du Fangyu; Dong Xiaoyu; Yang Jingyu; Wu Chunfu; (48 pag.)CN109320499; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem