Category: 77145-64-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 77145-64-3, name is 2-Chloro-6-(methylthio)pyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H6ClNS

(Example 15) 2-chloro-6-methylthiopyridine (1.00 g, 6.26 mmol) and succinimide (62 mg, 0.63 mmol) were mixed with toluene (20 mL). 10% aqueous solution of sodium hypochlorite (11.6 g, 15.7 mmol) was added dropwise to the mixture at 0 to 5C, and it was stirred for 1 hour. After that, ethyl acetate (10 mL), water (10 mL) and sodium sulfite (473 mg, 3.76 mmol) were added to the mixture, and it was stirred. After stirring and separation, an organic layer was concentrated under reduced pressure, and the residue was subjected to purification by means of a silica gel column to obtain 2-chloro-6-methylsulfonylpyridine (1.18 g, yield: 98%). 1H-NMR (300MHz, CDCl3) delta 3.26 (3H, s), 7.57-7.60 (1H, m), 7.90-8.05 (2H, m)

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Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2003116; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 77145-64-3, Adding some certain compound to certain chemical reactions, such as: 77145-64-3, name is 2-Chloro-6-(methylthio)pyridine,molecular formula is C6H6ClNS, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 77145-64-3.

(Example 16) 2-chloro-6-methylthiopyridine (208 mg, 1.30 mmol) and N-chlorosuccinimide (17 mg, 0.13 mmol) were mixed with ethyl acetate (2 mL). 10% aqueous solution of sodium hypochlorite (2.2 g, 2.93 mmol) was added to the mixture at room temperature, and it was stirred for 1 hour. After that, ethyl acetate (10 mL) and sodium sulfite (164 mg, 1.30 mmol) were added to the mixture, and it was stirred. After stirring and separation, an organic layer was concentrated under reduced pressure, and the residue was subjected to purification by means of a silica gel column to obtain 2-chloro-6-methylsulfonylpyridine (244 mg, yield: 98 %).

According to the analysis of related databases, 77145-64-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2003116; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem