Category: 771579-27-2

Electric Literature of 771579-27-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, molecular formula is C8H12N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Carboxylic acid (13.44g, 39.4mmol) was dissolved in 70mLDMSO, and added with stirring 4,6-dimethyl-3-aminomethyl-pyridinePyridine -2 (1H) – one (12.4g, 81.9mmol). Stirred at room temperature 15min, then add hexafluorophosphate, benzotriazol-1-yl – yloxy tripyrrolidinophosphonium phosphorus (PYBOP) (31.9g, 61.4mmol), stirred at room temperature overnight, until the reaction was complete (developing solvent: ethyl acetate / ethanol = 5: 1), the reaction mixture was poured into 700mL ice water, stirred for 30min, to obtain a solid by suction filtration, washed with a 500 mL of water, and dried under vacuum dryer, the resulting solid was added with stirring acetonitrile (75mL × 2), suction, vacuum dryer. The resulting solid was combined with 100mL stirring methanol / dichloromethane (5:95), filtration, and dried under reduced pressure to obtain a solid product was thoroughly 14g, Yield 74%

According to the analysis of related databases, 771579-27-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu University of Technology; Liang, Guoping; Wang, Yazhen; Zheng, Chunzhi; Zhao, Dejian; Zhang, Jizhen; (13 pag.)CN105440023; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 771579-27-2 ,Some common heterocyclic compound, 771579-27-2, molecular formula is C8H12N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

g) 6-bromo-N-((l,2-dihydro-4,6-dimethyl-2-oxopyridin-3-yl)methyl)-l-isopropyl-3-methyl-lH- indazole-4-carboxamideTo a stirred solution of 6-bromo-l-isopropyl-3-methyl-lH-indazole-4-carboxylic acid, 1 (6.5 g, 21.88 mmol) in DCM (250 mL) was added EDC HCl (5.01 g, 26.23 mmol), HOBt (3.545 g, 26.20 mmol) followed by diisopropyl ethyl amine (14.1 1 g, 109.37 mmol) and stirred at room temperature for 15 min. To the resulting mixture, 3-(amino methyl)-4,6-dimethylpyridin-2(lH)-one (3.32 g, 21.84 mmol) followed by DMAP (catalytic amount) was added and the reaction mixture was stirred at room temperature for 5 h. The reaction mixture was diluted with DCM (300 mL) and washed with IN HC1 solution (250 mL), saturated NaHC03 solution (250 mL) and brine solution. The organic layer was dried over anhydrous Na2S04 , filtered, and concentrated under reduced pressure. The residue was triturated with diethyl ether (100 mL), filtered, and dried to afford 6-bromo-N-((l,2-dihydro-4,6- dimethyl-2-oxopyridin-3-yl)methyl)-l-isopropyl-3-methyl-lH-indazole-4-carboxamide as an off white solid (5.5 g, 58 %). :H NMR (DMSO-d6, 400 MHz): delta 1.412 (d, J = 6.4 Hz, 6H), 2.1 12 (s, 3H), 2.215 (s, 3H), 2.383 (s, 3H), 4.319 (d, J = 5.2 Hz, 2H), 4.907 – 4.972 (m, 1H), 5.864 (s, 1H), 7.129 (d, J = 1.2 Hz, 1H), 8.01 1 (d, J = 1.2 Hz, 1H), 8.473 (t, J = 5 Hz, 1H), 11.479 (brs, 1H). LCMS (ES+): 431.02 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 771579-27-2, 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE LLC; DUQUENNE, Celine; JOHNSON, Neil; KNIGHT, Steven, D.; LaFRANCE, Louis; MILLER, William, H.; NEWLANDER, Kenneth; ROMERIL, Stuart; ROUSE, Meagan, B.; TIAN, Xinrong; VERMA, Sharad, Kumar; WO2011/140325; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H12N2O

[01751 ] The above acid (0.6 g, 2.2mmol) was then dissolved in DMSO (5 mL) and 3-(amino methyl)-4, 6-dimethylpyridin-2(l H)-one (0.67 g, 4.44 mmol) was added. The reaction mixture was stirred at room temperature for 1 5 min before PYBOP ( 1 .7 g, 3.33 mmol) was added and stirring was continued overnight. After completion of the reaction, the reaction mass was poured into ice; extraction was carried out using 10 % MeOH/DCM. The combined organic layers were dried over sodium sulphate and concentrated under reduced pressure to obtain crude material which was then purified by solvent washings giving the title compound (0.45 g, 50%). LCMS:402.20 (M + 1 )+; HPLC: 98.73% ((at) 254 nm) (R,;4.096; Method: Column: YMC ODS-A 150 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Inj . Vol: 10 mu, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1.5 min, 9.51 -12 min 5% B); ‘H NMR (DMSO-<¾, 400 MHz) delta 1 1 .47 (s, 1 H), 8.22 (t, 1 H, J=4.4 Hz), 6.97 (s, 1 H), 6.92 (s, 1 H), 5.85 (s, 1 H), 4.23 (d, 2H, J=4.4 Hz), 3.75-3.79 (m, 1 H), 2.87-2.93 (m,2H), 2.18 (s, 3H), 2.15 (s, 3H), 2.10 (s, 3H), 1 .99 (m, 2H), 1 .58- 1 .69 (m, 4H), 0.77 (t, 3H, J=6.8 Hz). With the rapid development of chemical substances, we look forward to future research findings about 771579-27-2. Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below., Quality Control of 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one

[01709] The above acid (0.47 g, 1 .52 mmol) was then dissolved in DMSO (5 mL) and 3- (amino methyl)-4, 6-dimethylpyridin-2( l H)-one (0.462 g, 3.04 mmol) was added.. The reaction mixture was stirred at room temperature for 15 min before PYBOP (1 .18 g, 2.28 mmol) was added to it and stirring was continued overnight. After completion of the reaction, reaction mass was poured into ice to obtain a solid which was filtered and dried to afford the title compound (0.40 g, 59%). LCMS: 444.25 (M + 1 )+; HPLC: 96.85% ((at) 254 nm) (R,;6.3 10; Method: Column: YMC ODS-A 150 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Jnj. Vol: 10 mu, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1 .5 min, 9.5 1 – 12 min 5% B); NMR (DMSO-Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, molecular formula is C8H12N2O, molecular weight is 152.1937, as common compound, the synthetic route is as follows.Product Details of 771579-27-2

[0793] Step 4: Synthesis of 3-bromo-N-((4,6-dimethyl-2-oxo-l ,2-dihydropyridin-3- yl)methyl)-l-isopropyl-6-(4-(morpholinomethyl)phenyl)-lH-pyrazolo[3,4-b]pyridine-4- carboxamide[0794] A solution of 3-bromo-l-isopropyl-6-(4-(morpholinomethyl)phenyl)-lH- pyrazolo[3,4-b]pyridine-4-carboxylic acid (0.8 g, 1.74 mmol) and 3-(aminomethyl)-4,6- dimethylpyridin-2(lH)-one (0.53 lg, 3.49 mmol) in DMSO (8 raL) and was stirred at room temperature for 15 min. Then PYBOP (1.36 g, 2.62 mmol) was added to it and stirring was continued for 12 hr. After completion of the reaction, reaction mass was poured into ice to obtain solid, which was filtered and solid was purified by silica gel column cliromatography to obtain the desired compound (39% yield). LCMS: 593.20 (M + 1)+; HPLC: 97.49% (@ 254 nm) (R,;5.338); NMR (DMSO-i?, 400 MHz) delta 1 1.48 (bs, 1H), 8.67 (t, 1H, J=4.8 Hz), 8.18 (d, 2H, J= 8.4 Hz), 7.73 (s, 1H), 7.47 (d, 2H, .1=8.4 Hz), 5.87 (s, 1H), 5.33-5.30 (m, 1 H), 4.40 (d, 2H, J= 4.4 Hz), 3.58 (bs, 4H), 3.53 (s, 2H), 2.38 (bs, 4H), 2.26 (s, 3H), 2.1 1 (s, 3H), 1.52 (d, 6H, J=6.4 Hz).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,771579-27-2, 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, and friends who are interested can also refer to it.

Reference:
Patent; EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William; WO2012/118812; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 771579-27-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one. A new synthetic method of this compound is introduced below.

[01759] The above acid (0.2 g, 0.68 mmol) was then dissolved in DMSO (0.5 mL) and 3- (amino methyl)-4, 6-dimethylpyridin-2(l H)-one (0.206 g, 1 .35 mmol) was added. The reaction mixture was stirred at room temperature for 15 min before PYBOP (0.528 g, 1 .01 mmol) was added t and stirring was continued overnight. The mixture was poured into ice and extraction was carried out using 10 % MeOH/DCM. The combined organic layers were dried over sodium sulphate and concentrated under reduced pressure to obtain crude material which was purified by column chromatography giving the title compound (0.2 g, 69 %). LCMS: 432.25 (M + 1 )+;HPLC: 99.95% ((at) 254 nm) (R,;5.750; Method: Column: YMC ODS-A 1 50 mm x 4.6 mm x 5 mu; Mobile Phase: A; 0.05% TFA in water/ B; 0.05% TFA in acetonitrile; Inj. Vol : ) 0 mu,, Col. Temp.: 30 C; Flow rate: 1 .4 mL/min.; Gradient: 5% B to 95% B in 8 min, Hold for 1.5 min, 9.5 1 – 12 min 5% B); NMR (DMSO- 6, 400 MHz) delta 1 1 .45 (s, 1 H), 8.19 (t, 1 H), 7.10 (d, 1 H, J= 1 .6 Hz), 6.90 (d, 1 H, J=2 Hz), 5.85 (s, 1 H), 4.23 (d, 2H, J=4.8 Hz), 3.80 (d, 2H, J=8.4 Hz), 3.21 -3.27 (m, 2H), 2.73 (d, 2H, J=7.2 Hz), 2.55 (s, 3H), 2.18 (s, 3H), 2.1 5 (s, 3H), 2.10 (s, 3H), 1 .74- 1.75 (m, 1 H), 1 .58- 1.61 (m, 2H), 1.07-1 .16 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,771579-27-2, its application will become more common.

Reference:
Patent; EPIZYME, INC.; EISAI CO., LTD.; KUNTZ, Kevin, Wayne; CHESWORTH, Richard; DUNCAN, Kenneth, William; KEILHACK, Heike; WARHOLIC, Natalie; KLAUS, Christine; ZHENG, Wanjun; WO2012/142513; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem