Category: 777899-57-7

Application of 777899-57-7 ,Some common heterocyclic compound, 777899-57-7, molecular formula is C7H5ClN2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 27A: Methyl 2-(1 ,4-diazabicvclo[3.2.2lnonan-4-yl)-5-nitroisonicotinateTo a solution of methyl 2-chloro-5-nitroisonicotinate (Intermediate 26A) (0.1 g, 0.46 mmol) in methanol (3 mL) under nitrogen was added 1 ,4-diazabicyclo[3.2.2]nonane (0.18 g, 0.55 mmol) and triethylamine (7 mg, 0.69 mmol), reaction then stirred overnight. The reaction mixture was concentrated and purified by a 10g silica column eluting with 40% ethylacetate in hexane to afford methyl 2-(1 ,4-diazabicyclo[3.2.2]nonan-4-yl)-5- nitroisonicotinate.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,777899-57-7, its application will become more common.

Reference:
Patent; N.V. ORGANON; RATCLIFFE, Paul David; CLARKSON, Thomas Russell; JEREMIAH, Fiona; MACLEAN, John Kinnaird Ferguson; WO2011/45258; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 777899-57-7, name is Methyl 2-chloro-5-nitroisonicotinate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H5ClN2O4

The starting material of tert-butyl ethyl malonate (41.7 g, 222 mmol, 1.2 eq.) was dissolved in anhydrous DMF (100 mL), cooled to 0 C, and stirred for 0.5 h. NaH (14.8 g, 370 mmol, 2 eq.) was added. After stirring for 0.5 h, methyl 2-chloro-5-nitroisonicotinate (40.0 g, 185 mmol, 1.0 eq.) was slowly added and stirred at room temperature for 5 h. The reaction was completely monitored by TLC, quenched with water at 0 C, concentrated, and extracted with EA (3×500 mL). The filtrate was concentrated under reduced pressure and the crude product was purified by silica gel column chromatography (PE: EA = 10: 1) to give the purified product (35g, yield: 51.4%).

With the rapid development of chemical substances, we look forward to future research findings about 777899-57-7.

Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Li Lin; Yang Xiaoju; (118 pag.)CN109575016; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem