Category: 778611-64-6

Adding a certain compound to certain chemical reactions, such as: 778611-64-6, 5-Bromo-2-chloro-4-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 778611-64-6, blongs to pyridine-derivatives compound. Safety of 5-Bromo-2-chloro-4-methylpyridine

Step 1: A mixture of compound 9-1 and aqueous EtNH2 (10 mL) in NMP (5 mL) was stirred for 3 days at 80C in a sealed tube, then concentrated. The residue was diluted with EtOAc (50 mL), washed with H20 (10 mL), brine (10 mL), dried over anhydrous Na2S04, concentrated, and purified by column chromatography, eluting with PE/EA = 4/1 to give target compound 9-2 as yellow oil. LC-MS: m/z = 215.0 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,778611-64-6, its application will become more common.

Reference:
Patent; BIOGEN IDEC MA INC.; HUTCHINGS, Richard, H.; JONES, John, Howard; CHAO, Jianhua; ENYEDY, Istvan, J.; MARCOTTE, Douglas; WO2014/28669; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 778611-64-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 778611-64-6, name is 5-Bromo-2-chloro-4-methylpyridine, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1 : To a solution of BB-3 (100 mg, 0.287 mmol) in toluene (10 mL), K2C03 (119 mg, 0.86 mmol), 5- bromo-2-chloro-4-methylpyridine (77 mg, 0.373 mmol) and Lambda/,/V -dimethyl ethylene diamine (13 mg, 0.143 mmol) were added and the mixture was degassed through purging with Ar for 30 min. Cul (27 mg, 0.14 mmol) was added and the RM was heated to 100C for 48 h. The RM was chilled, diluted with toluene and filtered over a plug of celite. The volatiles were removed under reduced pressure and the residue was purified by flash CC (silica gel, Hex/EtOAc) to yield the desired compound (60 mg, 45%).

According to the analysis of related databases, 778611-64-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 778611-64-6, Adding some certain compound to certain chemical reactions, such as: 778611-64-6, name is 5-Bromo-2-chloro-4-methylpyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 778611-64-6.

Lithium bis(trimethylsilyl)amide solution (1.0 M in tetrahydrofuran; 11.00 mL) is added drop wise to 5-bromo-2-chloro-4-picoline (950 mg) in tetrahydrofuran (15 mL) at -40 C. under an argon atmosphere. The mixture is stirred for 2 h at -35 C. to -45 C. prior to the addition of piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester (1.33 g), dissolved in tetrahydrofuran (15 mL). The reaction mixture is allowed to warm to room temperature over a period of 1 h. Ice cold water is added and the mixture is extracted with ethyl acetate. The combined extracts are washed with brine, dried over MgSO4, and concentrated in vacuo. The residue is chromatographed on silica gel (cyclohexane/ethyl acetate 75:25?60:40) to give the title compound. LC (method 5): tR=1.43 min; Mass spectrum (ESI+): m/z=417, 419 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 778611-64-6, 5-Bromo-2-chloro-4-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HIMMELSBACH, Frank; LANGKOPF, Elke; NOSSE, Bernd; US2013/18030; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem