Category: 779345-37-8

Electric Literature of 779345-37-8, Adding some certain compound to certain chemical reactions, such as: 779345-37-8, name is 5-Fluoro-2-nitropyridine,molecular formula is C5H3FN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 779345-37-8.

Synthesis of compound 224.1. To a solution of 220.1 (0.300g, 2.1 lmmol, l .Oeq) in DMSO(5ml) was added 2-methylpropan-2-amine (0.185g, 2.533mmol, 1.2eq.) and DIPEA (2.72g, 21.1 lmmol, lO.Oeq.). The reaction mixture was heated at 100 C for lh. After completion of reaction, mixture was poured in water, quenched with NH4C1 solution and extracted with EtOAc. Organic layers were combined, dried over sodium sulphate and concentrated under reduced pressure to obtain crude which was purified by chromatography to get pure 224.1 (0.225g, 54.59%). MS(ES): m/z 195.22 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 779345-37-8, 5-Fluoro-2-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NIMBUS LAKSHMI, INC.; MASSE, Craig E.; GREENWOOD, Jeremy Robert; ROMERO, Donna L.; HARRIMAN, Geraldine C.; WESTER, Ronald T.; SHELLEY, Mee; KENNEDY-SMITH, Joshua Jahmil; DAHLGREN, Markus; WO2015/131080; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 779345-37-8, name is 5-Fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 779345-37-8

To a solution of 2-bromo-4,6-dichlorophenol (2, 2.0 g, 14.0 mmol) in MeCN (20 ml), Cs2CO3 (5.50 g, 17.0 mmol) was added. After stirring at room temperature for 15 min, 5-fluoro-2-nitropyridine (12, 2.45 g, 14.0 mmol) was added dropwise and the reaction mixture was sealed for 16 h at 80 C. The reaction was concentrated in vacuo. The residue was purified by flash column chromatography [normal phase, silica gel (100-200 mesh), gradient 10% to 15% ethyl acetate in hexane] and then triturated with pentane (100 ml) to give 5-(2-bromo-4,6-dichlorophenoxy)-2-nitropyridine (13, 1.5 g, 50%) as an off-white solid. MS (ESI -ve): 363 1H-NMR (400 MHz; CDCl3): d 7.28 (d, J = 2.3 Hz, 1H), 7.52 (s, 1H), 7.64 (s, 1H), 8.22 – 8.30 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 779345-37-8, 5-Fluoro-2-nitropyridine.

Reference:
Article; O’Brien, Alistair; Andrews, Stephen P.; Baig, Asma H.; Bortolato, Andrea; Brown, Alastair J.H.; Brown, Giles A.; Brown, Sue H.; Christopher, John A.; Congreve, Miles; Cooke, Robert M.; De Graaf, Chris; Errey, James C.; Fieldhouse, Charlotte; Jazayeri, Ali; Marshall, Fiona H.; Mason, Jonathan S.; Mobarec, Juan Carlos; Okrasa, Krzysztof; Steele, Kelly N.; Southall, Stacey M.; Teobald, Iryna; Watson, Steve P.; Weir, Malcolm; Bioorganic and Medicinal Chemistry Letters; vol. 29; 20; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 779345-37-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 779345-37-8, name is 5-Fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 53.1 (0.2 g, 1.40 mmol, 1.0 e q) in DMSO (2.0 mL) was added (3aR,6aS)-hexahydro-1H-furo[3,4-c]pyrrole hydrochloride (0.21 g, 1.40 mmol, 1.0 eq.) and DIPEA (2.45 mL, 14.07 mmol, 10.0 eq.). The reaction mixture was stirred at 120 C. for 1 hour. After completion of the reaction, mixture was poured into water and product was extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2SO4 and concentrated under reduced pressure to obtain crude which was purified by column chromatography to provide 59.1 (0.23 g, 69.5%). MS(ES): m/z 236.17 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 779345-37-8, 5-Fluoro-2-nitropyridine.

Reference:
Patent; Nimbus Lakshmi, Inc.; Dahlgren, Markus; Greenwood, Jeremy Robert; Harriman, Geraldine C.; Kennedy-Smith, Joshua Jahmil; Masse, Craig E.; Romero, Donna L.; Shelley, Mee; Wester, Ronald T.; (131 pag.)US2016/251376; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 779345-37-8, 5-Fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 779345-37-8, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Fluoro-2-nitropyridine

To a stirred solution of 5-fluoro-2-nitropyridine (1.00 g, 7.04 mmol) in ethanol (20 mL) was added hunig’s base (2.5 mL, 14.084 mmol) and 2-(3-fluorophenyl)pyrrolidine (1.74 g, 10.56 mmol) at room temperature. The resulting mixture was stirred at 100C for 16 h in a sealed tube. On completion, Reaction mixture was concentrated under reduced pressure. The residue was diluted with water (30 mL) and extracted with ethyl acetate (2 x 30 mL). Combined organic layer was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound (1.8 g, 89%) as a pale brown solid. LCMS (ESI): m/z 288 [M + H+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,779345-37-8, its application will become more common.

Reference:
Patent; LEO PHARMA A/S; MAANSSON, Kristoffer; HENRIKSSON, Krister; (76 pag.)WO2020/35557; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 779345-37-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 779345-37-8, name is 5-Fluoro-2-nitropyridine. A new synthetic method of this compound is introduced below.

To a solution of compound 73 (564 mg, 4.2 mmol, 1.2 eq) in dimethylacetamide (5 mL) at 0 C under nitrogen was added potassium tert-butoxide (513 mg, 4.6 mmol, 1.3 eq) portion wise. The mixture was stirred at 0 C for 1 h, and then a solution of compound 61 (500 mg, 3.5 mmol, 1.0 eq) in DMA (2 mL) was added portion wise. After addition, the reaction mixture was stirred at RT overnight. The reaction was quenched by water (15 mL) and extracted with EA (3 X 5 mL), dried over Na2S04, filtered and concentrated to give a crude residue (700 mg crude), which was used into next step without further purification. *H NMR (300 MHz, CDCb): delta 8.34-8.31 (m, 2 H), 7.72 (dd, J = 3.0 Hz, 9.0 Hz, 1 H), 4.07 (d, J = 6.0 Hz 2 H), 2.80- 2.76 (m, 2 H), 2.15 (s, 3 H), 1.89-1.81 (m, 2 H), 1.75-1.71 (m, 2 H), 1.37-1.23 (m, 3 H). LCMS: (M+H)+ = 252.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,779345-37-8, its application will become more common.

Reference:
Patent; BEIJING XUANYI PHARMASCIENCES CO., LTD.; SONG, Yuntao; CHEN, Xiaoqi; (188 pag.)WO2019/35008; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 779345-37-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 779345-37-8, name is 5-Fluoro-2-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 1-azaadamantan-4-ol N-borane complex (1 eq.) and a heteroaryl halide (1.1 eq.) in anhydrous DMF (0.5-1 M) was chilled to between -20 and 0 C and treated with sodium hydride (1.5 equiv; 95%, Aldrich). After 15 minutes, the cooling bath was removed and the mixture was allowed to warm to room temperature. When 1 -azaadamantan-4-ol N-borane complex was consumed as determined by TLC analysis (generally 1-2 hours), the mixture was diluted with water and stirred for 1 hour. The resulting solid product was collected by filtration, washed with water, and dried under reduced pressure to afford the desired product; (4s)-4-(6-Nitropyridin-3-yloxy)-1-azatricyclo[3.3.1.13,7]decane N-borane complex Prepared from the product of Example 10A (419 g, 2.51 mmol) and 5-fluoro-2-nitropyridine (420 mg, 2.9 mmol; see US Patent Appl. 20040209886) according to Method A: 1H NMR (300 MHz, chloroform-D) delta ppm 1.68 – 1.78 (m, 2 H), 2.07 (s, 1 H), 2.20 – 2.35 (m, 4 H), 3.19 – 3 34 (m, 6 H), 4.74 (t, J=3.4 Hz, 1 H), 7.42 (dd, J=9.0, 2.9 Hz, 1 H), 8.26 – 8.31 (m, 2 H). MS (DCI/NH3) m/z= 290 (M+H)+

According to the analysis of related databases, 779345-37-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ABBOTT LABORATORIES; WO2008/58096; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 779345-37-8, 5-Fluoro-2-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H3FN2O2, blongs to pyridine-derivatives compound. Formula: C5H3FN2O2

Preparation 104-(6-Nitro-pyridin-3-yloxy)-piperidine-1-carboxylic acid tert-butyl esterAdd potassium tert-butoxide (4.84 g) to a solution of tert-butyl 4-hydroxy-1-piperidine-carboxylate (8.76 g) in dimethylacetamide (DMA, 39 mL) at 0 C. under nitrogen. Stir for 1 h and add drop wise a solution 5-fluoro-2-nitro-pyridine (5 g) in DMA (78 mL). Let the reaction stir at RT overnight. Add water and stand for 1 h. Filter, wash with water. Purify by silica gel column chromatography eluting with DCM/EA (0-15%) to afford 5.65 g of the title compound. MS (ES+): m/z=324 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,779345-37-8, 5-Fluoro-2-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; COATES, David A.; GELBERT, Lawrence Mark; KNOBELOCH, John M.; DE DIOS MAGANA, Alfonso; DE PRADO GONZALEZ, Ana; FILADELFA DEL PRADO CATALINA, Miriam; GARCIA PAREDES, Maria Cristina; MARTIN DE LA NAVA, Eva Maria; MARTIN ORTEGA FINGER, Maria Dolores; MARTINEZ PEREZ, Jose Antonio; MATEO HERRANZ, Ana Isabel; PEREZ MARTINEZ, Carlos; SANCHEZ MARTINEZ, Concepcion; US2010/160340; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem