Category: 796851-03-1

Reference of 796851-03-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 796851-03-1, name is 2,5-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

a) A mixture of 2,5-dichloro-4-iodopyridine (0.56 g, 2.04 mmol), 2-amino-N-methyl- 5-(4-methylpiperazin-l-yl)benzamide (0.508 g, 2.04 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (0.071 g, 0.12 mmol), cesium carbonate (1.332 g, 4.09 mmol) and palladium(II) acetate (0.018 g, 0.08 mmol) was suspended in DMA (15 mL). The mixture was heated at 1000C for 1 hour in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first using MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated to afford 2-[(2,5-dichloropyridin-4- yl)amino]-N-methyl-5-(4-methylpiperazin-l-yl)benzamide as a DMA adduct (0.990 g); 1H NMR spectrum: (300 MHz, DMSO) delta 2.23 (3H, s), 2.44 – 2.50 (4H, m), 2.73 (3H, d), 3.16 – 3.21 (4H, m), 6.90 (IH, s), 7.10 – 7.14 (IH, m), 7.20 (IH, d), 7.40 (IH, d), 8.19 (IH, s), 8.58 (IH, d), 9.67 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 394.09.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 796851-03-1, 2,5-Dichloro-4-iodopyridine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 796851-03-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 796851-03-1, name is 2,5-Dichloro-4-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2,5-dichloro-4-iodopyridine (3.86 g, 14.09 mmol, 1.00 equiv), 5-(tetramethyl- 1,3,2-dioxaborolan-2-yl)-2-(trifluoromethyl)pyrimidine (4.26 g, 15.54 mmol, 1.10 equiv), potassium carbonate (5.83 g, 42.19 mmol, 2.99 equiv), and Pd(dppf)C12 (516 mg, 0.70 mmol, 0.05 equiv) in dioxane (50 mL)/water (5 mL) was stirred for 12 h at 60C under nitrogen. The solids were filtered out. The filtrate was diluted with ethyl acetate, washed with brine, dried over anhydrous sodium sulfate, and concentrated under vacuum. The residue was purified by a silica gel column eluting with acetate/petroleum ether (1/100) to afford the title compound (2.2 g, 53%) as a yellow solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 796851-03-1, 2,5-Dichloro-4-iodopyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; CHEN, Huifen; CHU, Yanyan; DO, Steven; ESTRADA, Anthony; HU, Baihua; KOLESNIKOV, Aleksandr; LIN, Xingyu; LYSSIKATOS, Joseph P.; SHORE, Daniel; VERMA, Vishal; WANG, Lan; WU, Guosheng; YUEN, Po-wai; WO2015/52264; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 796851-03-1, 2,5-Dichloro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,5-Dichloro-4-iodopyridine, blongs to pyridine-derivatives compound. Recommanded Product: 2,5-Dichloro-4-iodopyridine

a) A mixture of 2,5-dichloro-4-iodopyridine (0.2 g, 0.73 mmol), 7-amino-2-methyl- 3H-isoindol-l-one (0.118 g, 0.73 mmol), palladium(II) acetate (6.56 mg, 0.03 mmol), 9,9- dimethyl-4,5-bis(diphenylphosphino)xanthene (0.025 g, 0.04 mmol) and cesium carbonate (0.476 g, 1.46 mmol) were suspended in dioxane (5 mL). The mixture was heated at 1000C for 30 minutes in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution OfNH3 in MeOH. Fractions containing product were combined and evaporated. A solid recovered from the top of the column was washed with water, dried in vacuo, and combined with the evaporated residue to afford 7-[(2,5-dichloropyridin-4- yl)amino]-2-methyl-3H-isoindol-l-one (0.160 g, 71% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 3.07 (3H, s), 4.50 (2H, s), 7.25 – 7.28 (IH, m), 7.48 (IH, s), 7.56 – 7.63 (2H, m), 8.36 (IH, s), 9.80 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 308.01 and 309.97 and 311.99.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,796851-03-1, 2,5-Dichloro-4-iodopyridine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 796851-03-1 , The common heterocyclic compound, 796851-03-1, name is 2,5-Dichloro-4-iodopyridine, molecular formula is C5H2Cl2IN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

a) A mixture of 2,5-dichloro-4-iodopyridine (0.4Og, 1.46 mmol), 7-amino-2-methyl-4- (4-propan-2-ylpiperazin-l-yl)-3H-isoindol-l-one (0.421 g, 1.46 mmol), 9,9-dimethyl-4,5- bis(diphenylphosphino)xanthene (0.051 g, 0.09 mmol), cesium carbonate (0.952 g, 2.92 mmol) and palladium(II) acetate (0.013 g, 0.06 mmol) was suspended in DMA (15 mL). The mixture was heated at 1000C for 1 hour in a microwave reactor and then allowed to cool to room temperature. The mixture was loaded onto an SCX column and the product eluted first with MeOH and then with a 7M solution of NH3 in MeOH. Fractions containing product were combined and evaporated to afford 7-[(2,5-dichloropyridin-4- yl)amino]-2-methyl-4-(4-propan-2-ylpiperazin-l-yl)-3H-isoindol-l-one (0.630 g, 99% yield); 1H NMR spectrum: (300 MHz, DMSO) delta 1.01 – 1.18 (3H, d), 2.60 – 2.64 (4H, m), 3.04 – 3.09 (5H, m), 4.51 (2H, s), 7.16 (IH, d), 7.29 (IH, s), 7.50 (IH, d), 8.28 (IH, s), 9.59 (IH, s); Mass spectrum: m/z (ESI+) (M+H)+ = 434.0 and 436.0 and 438.0.

The synthetic route of 796851-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/153589; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem