Category: 799293-83-7

Adding a certain compound to certain chemical reactions, such as: 799293-83-7, 3-Bromothieno[3,2-c]pyridin-4(5H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 3-Bromothieno[3,2-c]pyridin-4(5H)-one, blongs to pyridine-derivatives compound. Safety of 3-Bromothieno[3,2-c]pyridin-4(5H)-one

Step-1: (0216) (0217) Preparation of 3-(4-chloro-3-(trifluoromethyl)phenyl)thieno[3,2-c]pyridin-4(5H)-one: (0218) [00115] To a solution of 3-bromothieno[3,2-c]pyridin-4(5H)-one (0.55 g, 2.17 mmol) and (4-chloro-3-(trifluoromethyl)phenyl)boronic acid (0.73 g, 3.25 mmol) in 1,4-dioxane:water mixture (20 mL, 4:1), potassium carbonate (0.9 g, 6.51 mmol) was added. The reaction mixture was purged with argon for 15 minutes and PdCl2(PPh3)2 (0.15 g, 0.21 mmol) was added. Then the reaction mixture was stirred at 100 C for 18 h. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (3 x 100 mL). The combined organic layer was dried over anhydrous sodium sulphate, filtered and concentrated. The crude product was purified by silica gel column chromatography using 30% ethyl acetate in hexane to afford the title compound 3-(4-chloro-3-(trifluoromethyl)phenyl)thieno[3,2-c]pyridin-4(5H)- one (0.74 g, 94% yield) as off-white solid. Calculated (M+H): 330; Found (M+H): 330.0.

The synthetic route of 799293-83-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUC THERAPEUTICS; ANDERSON, David, R.; VOLKMANN, Robert, A.; MENNITE, Frank, S.; FANGER, Christopher; (390 pag.)WO2017/100591; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 799293-83-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 799293-83-7 as follows.

3-Bromothieno[3,2-c]pyridin-4(5H)-one (1.09 g, 4.74 mmol) synthesized according to a known method (WO2004/100947) was suspended in DMF (24 mL), and potassium carbonate (1.96 g, 14.2 mmol) and methyl 4-toluenesulfonate (0.858 mL, 5.68 mmol) were added. The mixture was stirred overnight at room temperature. After adding a saturated sodium bicarbonate aqueous solution to the reaction mixture, the insoluble matter was filtered, and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The obtained residue was washed with diethyl ether to give Compound bc (670 mg, 58 %). ESI-MS: m/z 244 [M + H]+. 1H-NMR (CDCl3) delta (ppm): 7.23 (s, 1H), 7.19 (d, J = 7.8 Hz, 1H), 6.62 (d, J = 7.8 Hz, 1H), 3.60 (s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-83-7, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; OTSUBO, Nobumasa; OKAZAKI, Shuko; TSUKUMO, Yukihito; IIDA, Kyoichiro; NAKOJI, Masayoshi; EP2708540; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem