Category: 799293-85-9

Reference of 799293-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine. A new synthetic method of this compound is introduced below.

To a solution of 3-bromo-thieno[2,3-c]pyridine-4-yl-amine (1.00 g, 4.38 mmol) in DMF (15 mL) was added NIS (1.08 g, 4.81 mmol). The resulting solution was stirred at room temperature overnight. Approximately half of the solvent was removed in vacuo and the resulting slurry was poured into sodium thiosulfate (5% solution in water, 100 mL). The resulting precipitate was collected and washed with water (2 x 30 mL) to afford 4-amino-7- biphenyl-3-yl-thieno[3,2-c]pyridine carboxylic acid as a tan solid (1.55 g, 4.38 mmol); RP- HPLC (Table 1, Method i) Rt 2.72 min; m/z: (M + H) + 357.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-85-9, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 799293-85-9, Adding some certain compound to certain chemical reactions, such as: 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine,molecular formula is C7H5BrN2S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 799293-85-9.

EXAMPLE 10A 3-(4-phenoxyphenyl)thieno[3,2-c]pyridin-4-amine A mixture of Example 1B (1.5 g, 6.5 mmol), 4-phenoxyphenylboronic acid (1.53 g, 7.1 mmol) and Na2CO3 (1.81 g, 17.1 mmol) in toluene (26 mL), ethanol (5 mL), and water (10 mL) was purged with nitrogen for 45 minutes, then treated with Pd(PPh3)4 (0.382 g, 0.33 mmol) and heated to 90 C. overnight. The reaction was cooled to room temperature and partitioned between water and ethyl acetate. The aqueous phase was extracted with ethyl acetate twice and the combined organic extracts were washed with brine, dried (Na2SO4), filtered, and concentrated. The residue was purified by flash column chromatography on silica gel with 40% ethyl acetate/hexanes to provide 1.69 g (82% yield) of the desired product. MS (ESI(+)) m/e 318.9 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 799293-85-9, 3-Bromothieno[3,2-c]pyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Betschmann, Patrick; Burchat, Andrew F.; Calderwood, David J.; Curtin, Michael L.; Davidsen, Steven K.; Davis, Heather M.; Frey, Robin R.; Heyman, Howard R.; Hirst, Gavin C.; Hrnciar, Peter; Michaelides, Michael R.; Muckey, Melanie A.; Rafferty, Paul; Wada, Carol K.; US2005/43347; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem