Category: 80-32-0

Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideIn 2022, Chen, Qincheng;Cheng, Zhiwen;Li, Xiaoying;Wang, Chen;Yan, Lili;Shen, Guoqing;Shen, Zhemin published 《Degradation mechanism and QSAR models of antibiotic contaminants in soil by MgFe-LDH engineered biochar activating urea-hydrogen peroxide》. 《Applied Catalysis, B: Environmental》published the findings. The article contains the following contents:

Developing an in-situ soil remediation technol. for simultaneous catalytic degradation of contaminants and nitrogen supplementation is of great importance but remains challenging. Herein, MgFe-LDH engineered biochar (MB) was successfully synthesized by using a simple co-precipitation method. The as-prepared materials were used as catalysts for the first time to activate urea-hydrogen peroxide (UHP) to degrade antibiotic sulfamethoxazole (SMX) and provide nitrogen. The enhanced degradation efficiency of SMX (91%) were mainly attributed to •OH and ¹O₂-mediated oxidation Pot experiments showed MB/UHP significantly decreased the SMX concentration from 6.47 to 2.10 mg kg^-1 and simultaneously increased NH⁺₄-N and NO^–₃-N concentration The optimal quant.-structure-activity-relationship model for 19 antibiotics suggested the dipole moment, energy of the HOMO, and bond order were the intrinsic influencing factors. This study not only provides a green remediation technol. but also offers a theor. basis for estimating the removal rate of unexplored antibiotics. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Paoletti, Fabiola;Sdogati, Stefano;Barola, Carolina;Giusepponi, Danilo;Moretti, Simone;Galarini, Roberta published 《Two-procedure approach for multiclass determination of 64 antibiotics in honey using liquid chromatography coupled to time-of-flight mass spectrometry》. The research results were published in《Food Control》 in 2022.COA of Formula: C10H9ClN4O2S The article conveys some information:

A “two-procedure approach” was developed to detect and confirm residues of 64 antibiotic substances in honey using liquid-chromatog. coupled to quadrupole time-of-flight mass spectrometry. Eight antimicrobial classes were determined (amphenicols, lincosamides, macrolides, nitroimidazoles, pleuromutilins, quinolones, sulfonamides and tetracyclines) together with single drugs. The procedures were validated in the range 0.2-50μg kg-1, obtaining recovery factors from 67 to 100% and coefficients of variation in within-lab reproducibility conditions lower than 20%. Limits of detection and quantification were in the ranges 0.1-3.3μg kg-1 and 0.2-11μg kg-1, resp., satisfying the current European levels for anal. control of antibiotic residues in honey. An extensive matrix effect study was performed considering acacia, chestnut and multiflower honey types. Method performances were confirmed through participation in proficiency tests obtaining z-scores between -0.7 and +1.08. The proposed approach was applied to honey samples collected in local markets and three out of fifty-five samples tested pos. The found mols. were sulfonamides (sulfamethazine and sulfathiazole) and tetracyclines (oxytetracycline and tetracycline) at concentrations lower than 2μg kg-1. Two out of three contaminated samples contained honey from extra-EU countries.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.COA of Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of C10H9ClN4O2SIn 2021, Hu, Yaru;Jin, Lei;Zhao, Yi;Jiang, Lei;Yao, Shijie;Zhou, Wang;Lin, Kuangfei;Cui, Changzheng published 《Annual trends and health risks of antibiotics and antibiotic resistance genes in a drinking water source in East China》. 《Science of the Total Environment》published the findings. The article contains the following contents:

The extensive pollution of antibiotics and antibiotic resistance genes (ARGs) in drinking water has aroused worldwide concern. Successive monitoring of these pollutants has noteworthy significance for drinking water safety. Accordingly, this study conducted successive monitoring of antibiotics and ARGs from 2015 to 2017 in a drinking water source in East China. The total antibiotic concentration ranged from 19.68 ng/L to 497.00 ng/L, and decreased slightly from 2015 to 2017. Eighteen out of forty-one ARG subtypes showing resistance to six antibiotic classes and one class I integrase gene intI1, were detected in the drinking water source at concentrations ranging from 6.5 x 104 copies/mL to 1.6 x 106 copies/mL. Importantly, the total ARG concentration increased on an annual basis from 2015 to 2017 with an average annual increment of 0.25 orders of magnitude, which was mainly attributed to the increase in specific ARG subtypes, such as sul1, sul2, sul3, tetA, qnrB, and ermB. Most ARGs was pos. correlated with the intI1 genes (r = 0.47-0.55, P < 0.01). Furthermore, the variation of antibiotics and ARGs appeared to be related to the water indexes, particularly of the values of COD, BOD₅, NO₂-N (P < 0.05). This study provides basic data on antibiotic and ARG pollution in the studied drinking water source. Importantly, the findings expound that although the residual antibiotics in this drinking water source decreased slightly from 2015 to 2017, while its biol. effect, the antibiotic resistance, increased annually, which give a warning of the antibiotic resistance pollution in the drinking water source. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Electric Literature of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

de Campos, Victoria M.;Andrade, Mariane A.;Maciel, Edvaldo V. S.;de Toffoli, Ana Lucia;Lancas, Fernando M. published 《Environmentally friendly analysis of sulphonamides in Brazilian honey through automated and miniaturised sample preparation coupled with LC-MS/MS》 in 2022. The article was appeared in 《Food Additives & Contaminants, Part A》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

Increased use of environmentally friendly practices has become a trend in science because of the current awareness regarding climate change and related issues. Similarly for anal. chem., considering the development of greener methods for reducing the use of reagents and samples and also toxic waste generation. To meet such goals, automation, and miniaturization of sample preparation-a well-recognized laborious and time-consuming anal. step-are two promising strategies. This work associates the greener aspects of miniaturization and the performance of automated sample preparation Therefore, we proposed an anal. method using a miniaturized extraction column for pre-concentrating sulphamerazine, sulphamethazine, sulphamethoxazole, sulphadimethoxine, sulphathiazole, and sulphachlorpyridazine from honey and cleaning-up the samples. Several variables were optimized: extractive phase, loading flow, loading phase, and loading time. Under optimized conditions, the method showed adequate linearity between 5.0 and 60 ng g-1 with R > 0.99, and also good selectivity and recovery (114.6-124.1%) which are acceptable according to Brazilian legislation. Intra and inter-day precision were in the range 3.0-5.0%. Although sulfonamides were detected in one of the eight com. honey samples, the value was below the established MRL. The method showed efficiency, while also exhibiting greener characteristics resulting from miniaturization and automation, representing a promising environmentally friendly alternative for conventional sample preparation methods. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shahriman, Mohamad Shariff;Mohamad, Sharifah;Mohamad Zain, Nur Nadhirah;Alias, Yatimah;Chandrasekaram, Kumuthini;Raoov, Muggundha published 《Paper-based polymeric ionic liquid for thin film micro extraction of sulfonamides in environmental water samples prior to HPLC-DAD analysis》. The research results were published in《Microchemical Journal》 in 2021.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:

Paper-based polymeric ionic liquid (p-Poly-(MMA-IL)) was successfully developed by grafting the polymeric ionic liquid on the surface of com. filter paper by using dipping method, presenting a new cost-effective film. The newly developed p-Poly-(MMA-IL) was then applied as a paper-based thin film microextraction (p-TFME) to extract four representative sulfonamides (SAs) drugs, which were sulfadiazine, sulfachloropyridazine, sulfamethoxazole, and sulfadimethoxine in environmental water samples. Besides, p-Poly-(MMA-IL) was successfully characterised by FTIR, FESEM, and XRD techniques and underwent significant parameters optimization, which affected the extraction efficiency. Under optimal conditions, the proposed method (p-Poly-(MMA-IL)-TFME) was evaluated and applied to analyze SAs in environmental water samples by using a high-performance liquid chromatog.-diode array detector (HPLC-DAD). The validation method showed that a good linearity (0.50 μg L^-1 -500 μg L^-1) was noted (R² > 0.999, n = 3). Detection and quantification limits were within 0.14 μg L^-1 – 0.52 μg L^-1 and 0.41 – 1.57 μg L^-1, resp., the preconcentraction factors were > 14.95, and the matrix effect was less than 2.64%, an acceptable percentage for real samples anal. The extraction recoveries of environmental water samples were ranged from 90.4% to 109.9% with a relative standard deviation (RSD) of less than 9.8%. The newly developed paper-based polymeric ionic liquid p-Poly-(MMA-IL) for anal. of SAs under the p-TFME procedure was successfully achieved with limited sample volume and organic solvent, fast extraction, and practicable in the daily anal. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Reference of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Chunmeng;Shi, Jiaqi;Zhang, Xuesheng;Qin, Li;Jiang, Zhongguan;Wang, Jinhua;Li, Yucheng;Liu, Bingxiang published 《Occurrence and bioaccumulation of sulfonamide antibiotics in different fish species from Hangbu-Fengle River, Southeast China》 in 2021. The article was appeared in 《Environmental Science and Pollution Research》. They have made some progress in their research.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

As a class of synthetic sulfur drugs, sulfonamides (SAs) have been used to treat diseases and promote organism growth. Different concentrations of SAs have been detected in the water environment, which has threatened the ecol. environment. In this study, the contamination of 9 SAs in water, sediments, and 8 fish species from the Hangbu-Fengle River, China, were analyzed using UPLC-MS/MS. The total SA concentrations in surface water, sediments, and fish were ND-5.064 ng/L, ND-5.052 ng/g dry weight (d.w.), and ND-1.42 ng/g wet weight (w.w.), resp. The major compounds were sulfadiazine (SDZ), sulfamerazine (SMZ), and sulfamethoxazole (SMX) in water and fish. The SA levels of in fish from different habitat preferences revealed a spatial difference, with the order of demersal species > pelagic species. Moreover, the SA concentrations were affected by trophic guilds, indicating their decrease in the order of piscivorous fish > omnivorous fish > planktivorous fish > herbivorous fish. The obtained bioaccumulation factors showed that SMZ and SMX have strong bioenrichments in Ophiocephalus argus Cantor and Pelteobagrus fulvidraco. The risk assessment indicated that SAs did not pose significant health threats to the organisms. This research is the first report of SA contamination in the Hangbu-Fenle River, which can provide an important scientific basis for their pollution prevention and ecol. risk assessment in the aquatic environment.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamideDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Ruidong;Mu, Shuhe;Feng, Tengwang;Liu, Huan;Sun, Huiwu;Li, Jincheng published 《Development of a vortex oscillating clean-up column for high-throughput semi-automatic sample preparation of drug residues in fish muscle tissues》 in 2022. The article was appeared in 《Journal of Food Composition and Analysis》. They have made some progress in their research.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

A novelty high-throughput semi-automatic sample clean-up method was developed and used for rapid anal. of 9 drug residues in fish muscle tissues combined with high-performance liquid chromatog./quadrupole-linear ion trap mass spectrometry (HPLC-QTRAP-MS/MS). The target compounds were extracted by Quick, Easy, Cheap, Effective, Rugged and Safe multiresidue (QuEChERS) method with acetonitrile. A vortex oscillating clean-up column was proposed for single step purification firstly. After centrifugation, 1 mL of acetonitrile layer was transferred into a 3 mL vortex oscillating clean-up column which packed with 150 mg C₁₈ sorbent. The column was covered with piston, placed on a column-tube rack, vigorously agitated on a multi-tube vortex mixer. After vortex oscillation, purified extract was obtained for anal. by pushing the piston of oscillating clean-up column. The performance of the developed method was validated by analyzing 9 analytes in spiked grass carp muscle tissues. The limits of quantification (LOQs) ranged from 1.0 to 5.0 μg kg^-1. The recoveries were in the range of 101-119% at the four concentration levels (2.0, 5.0, 10.0, 20.0 μg kg^-1). Inter-day and intra-day relative standard deviations (RSDs) were lower than 16% for all analytes. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Recommanded Product: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C10H9ClN4O2S《Comparison and prioritization of antibiotics in a reservoir and its inflow rivers of Beijing, China》 was published in 2022. The authors were Hu, Jingrun;Qi, Dianqing;Chen, Qian;Sun, Weiling, and the article was included in《Environmental Science and Pollution Research》. The author mentioned the following in the article:

The occurrence of antibiotics in drinking water resources, like reservoirs, is of considerable concern due to their potential risks to ecosystem, human health, and antimicrobial resistance development. Here, we quantified 83 antibiotics in water and sediments of wet and dry seasons from the Miyun reservoir and its inflow rivers in Beijing, China. Twenty-four antibiotics were detected in water with concentrations of ND-11.6 ng/L and 19 antibiotics were observed in sediments with concentrations of ND-6.50 ng/g. Sulfonamides (SAs) were the dominated antibiotics in water in two seasons. SAs and quinolones (QNs) in wet season and macrolides (MLs) and QNs in dry season predominated in sediments. The reservoir and inflow rivers showed significant differences in antibiotic concentrations and compositions in water and sediments. As an important input source of reservoir, the river water showed significantly higher total antibiotic concentrations than those in the reservoir. In contrast, the reservoir sediments are the sink of antibiotics, and had higher total antibiotic concentrations compared with rivers. A prioritization approach based on the overall risk scores and detection frequencies of antibiotics was developed, and 3 (sulfaguanidine, anhydroerythromycin, and sulfamethoxazole) and 5 (doxycycline, sulfadiazine, clarithromycin, roxithromycin, and flumequine) antibiotics with high and moderate priority, resp., were screened. The study provides a comprehensive insight of antibiotics in the Miyun Reservoir and its inflow rivers, and is significant for future monitoring and pollution mitigation of antibiotics. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Computed Properties of C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Lei;Wu, Xiaona;Chen, Xiaoyu;Chen, Fei;Zheng, Xiaona;Song, Qinan;Liu, Xiang;Li, Miao published 《Synergistic Removal of Nutrient Pollutants and Pharmaceutical and Personal Care Products (PPCPs) from Contaminated Groundwater: Macro- and Microelements and Microorganisms》. The research results were published in《ACS ES&T Water》 in 2022.Related Products of 80-32-0 The article conveys some information:

The synergistic removal performance of nutrient pollutants and pharmaceutical and personal care products (PPCPs) from contaminated groundwater, and the biogeochem. interactions of macro- and microelements-contaminants-microorganisms were further studied. The electrolysis-zeolite/basalt system proved to achieve better synergistic removal performance than all other purification systems considered, reaching average removal efficiencies of 85.8% for nutrient pollutants and 74.7% for PPCPs. Electrolysis not only enhanced the abundance and distribution of MOB and DNB, but also promoted the production of microelements Fe³⁺ (0.1 ± 0.1 mg/L) and Zn²⁺ (0.3 ± 0.3 mg/L). Macroelements Ca²⁺ and Mg²⁺ increased by 27.8 ± 2.7 and 16.5 ± 9.6 mg/L, resp., which significantly stimulated the activities of function microbials. Microelements Fe3+ exchanged from zeolite, Mn²⁺ from basalt, and Cu²⁺ from groundwater itself were crucial for enzyme activity. Meanwhile, Mn²⁺ was co-regulated by oxidation-reduction processes and ion-exchange strength. Thus, the electrolysis-zeolite/basalt system is a promising technol. for synergistic nutrient pollutant and PPCP removal from contaminated groundwater, especially in dispersive water supplied in the countryside of China.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Related Products of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ji, Baocheng;Zhao, Wenhao;Xu, Xu;Han, Yu;Jie, Mingsha;Xu, Gaigai;Bai, Yanhong published 《Development of a modified quick, easy, cheap, effective, rugged, and safe method based on melamine sponge for multi-residue analysis of veterinary drugs in milks by ultra-performance liquid chromatography tandem mass spectrometry》. The research results were published in《Journal of Chromatography A》 in 2021.Recommanded Product: 80-32-0 The article conveys some information:

The purpose of this study was to develop a modified QuEChERS method based on melamine sponge for rapid determination of multi-class veterinary drugs in milks by UPLC-MS/MS. Through simple infiltration and extrusion, fast and convenient matrix purification could be achieved within several seconds, and there was no need of extra phase separation operations. Good linearity with correlation coefficient (R2) ≥0.999 was obtained for all drugs in the range of 2∼500μg·kg-1. The obtained matrix effects were within ±20% for all monitored drugs. The recoveries of all monitored drugs ranged from 60.7% to 116.0% at three spiked levels (50, 100, and 200μg·kg-1), with relative standard deviations less than 7.4%. Comparatively low LODs and LOQs were obtained in the ranges of 0.1∼3.8μg·kg-1 and 0.2∼6.3μg·kg-1, resp. Compared with conventional purification adsorbents, melamine sponge yielded an equal or higher purification performance with matrix removal rate as high as 52.5% and acceptable recoveries in range of 60%-120% for all monitored drugs. The satisfactory results have demonstrated the good potential of melamine sponge in matrix purification for rapid determination of multiclass residues in food safety. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Recommanded Product: 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem