Category: 80-32-0

Zhang, Yue;Li, Yang;Liu, Xiaoxia;Sun, Ying published 《Determination of multiple antibiotics in agricultural soil using a quick, easy, cheap, effective, rugged, and safe method coupled with ultra-high performance liquid chromatography-tandem mass spectrometry》 in 2022. The article was appeared in 《Journal of Separation Science》. They have made some progress in their research.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article mentions the following:

In this study, we combined ultra-high performance liquid chromatog. with tandem mass spectrometry to establish a quick, easy, cheap, effective, rugged, and safe method of detecting 21 target antibiotics in agricultural soil samples. Antibiotics were extracted with mixed solvents consisting of EDTA disodium salt dihydrate and phosphoric acid citric acid buffer and acetonitrile which were purified with octadecylsilyl as an adsorbent and anhydrous sodium sulfate as a desiccant. This method was able to effectively extract all of the target antibiotics from agricultural soils, with recovery efficiencies ranging from 55 to 108% and limits of detection between 0.09-0.68μg/kg. We also validated this new method for selectivity, sensitivity, and reliability of detecting multiple antibiotics in 12 samples. Considering the potential environmental and public health effects of antibiotics in agricultural soils, our new method can help analyze the degree of antibiotic contamination and provide valuable information for soil quality and risk assessment.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Application In Synthesis of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pokrant, Ekaterina;Trincado, Lina;Yevenes, Karina;Terraza, Gigliola;Maddaleno, Aldo;Martin, Betty San;Zavala, Sebastian;Hidalgo, Hector;Lapierre, Lisette;Cornejo, Javiera published 《Determination of five antimicrobial families in droppings of therapeutically treated broiler chicken by high-performance liquid chromatography-tandem mass spectrometry》. The research results were published in《Poultry Science》 in 2021.Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:

Antimicrobials are currently used in poultry for disease treatment. However, their excretion in bird feces may contaminate the environment. Considering this, the objective of this work was to quantify antimicrobials residues concentrations in therapeutically treated broiler chicken droppings throughout the post-treatment period. For this aim a multiresidue method using high-performance liquid chromatog.-tandem mass spectrometry (HPLC-MS/MS) was validated. Forty-eight male broiler chickens were distributed and treated with com. formulations of 5 different antimicrobials. Anal. showed that oxytetracycline and 4-epi-oxytetracycline, presented the highest concentrations during all sampling period, detecting concentrations of 1471.41μg kg-1 at the last sampling point (day 22 post-treatment). Florfenicol, tylosin, enrofloxacin, and ciprofloxacin were eliminated and detected in treated chicken droppings until d 18 post-treatment. Sulfachloropyridazine decrease gradually during post-treatment period until day 30. Anal. demonstrate that studied antimicrobials in treated chicken droppings were eliminated for prolonged periods, therefore becoming a significant route of residues dissemination into the environment. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C10H9ClN4O2SIn 2022, Hu, Yabin;Li, Juan;Yuan, Tao;Yu, Tingting;Chen, Yao;Kong, Huijun;Lin, Cuilan;Shen, Zhemin;Tian, Ying;Tong, Shilu;Yu, Xiaodan;Liu, Shijian published 《Exposure to antibiotics and precocious puberty in children: A school-based cross-sectional study in China》. 《Environmental Research》published the findings. The article contains the following contents:

Foods and water can be contaminated with antibiotics in China, which may affect children′s health, but evidence on antibiotic exposure with precocious puberty (PP) is limited. This study explored the association of antibiotic exposure with PP in a school-based setting. A cross-sectional study with multistage stratified cluster random sampling was conducted in Zhongshan City, Guangdong Province and Qufu City, Shandong Province in China from Oct. 11 to Dec. 5, 2019. A first-morning urine sample was collected to detect antibiotic exposure. We detected 33 of 45 types of antibiotics from eight categories in 928 primary school children aged 6-12 years using HPLS-MS/MS. Detection rate of antibiotics was stratified by sex, study site, and BMI. The Tanner stages were assessed by professional pediatricians from local hospitals. PP is defined as the onset of secondary characters before 8-yr-old or menarche before 10-yr-old for girls and before 9-yr-old for boys. Multivariable logistic regression was performed to examine the association between antibiotic exposure and PP after adjusting potential confounders. The overall detection rate of antibiotics was 93.0% in 928 children. We found the detection rate of tetracyclines and fluoroquinolones in children with PP was significantly higher than that of children with normal puberty (41.4% vs 29.9%, 56.8% vs 50.6%, resp., all p < 0.05). Both fluoroquinolones (odds ratio (OR): 1.835, 95% confidence interval (CI): 1.066-3.158) and tetracyclines (OR: 2.120, 95% CI: 1.175-3.825) were associated with increased OR of PP after adjusting sex, age, BMI, study site, and family income. Specifically, compared to the values less than the limits of detection, low concentration of ofloxacin from fluoroquinolones (OR: 2.056, 95% CI: 1.091-3.875) and high concentration of chlortetracycline (OR: 3.027, 95% CI: 1.126-8.140) and tetracycline from tetracyclines (OR: 2.756, 95% CI: 1.167-6.506) were associated with increased OR of PP. Exposure to antibiotics, especially fluoroquinolones and tetracyclines was pos. associated with precocious puberty. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Computed Properties of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yin, Fubin;Dong, Hongmin;Zhang, Wanqin;Wang, Shunli;Cao, Qitao;Lian, Tianjing published 《Antibiotic removal potential for low greenhouse gas emission process of anaerobic digestion (AD) producing volatile fatty acids (VFAs)》. The research results were published in《Bioresource Technology》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:

This study aimed to investigate the antibiotic of sulfachloropyridazine (SCP) reduction and its effects on volatile fatty acids (VFAs) accumulation and microbial community structures during the process of anaerobic digestion (AD) producing VFA. Results showed that initial SCP concentrations have a pos. correlation with reduction of SCP and accumulation of VFAs. The removal rates of SCP were 22.21%, 30.00%, 39.31% and 42.59% and the maximum production of VFAs were 3947, 6180, 6462 and 6032 mg/L for initial SCP concentrations of 25, 50, 75 and 100 mg/kg·TS, resp. SCP only altered bacterial composition by hastening growth of specific bacterial taxa, but didn’t increase bacterial α-diversity. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Synthetic Route of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hu, Yu;Wei, Xianping;Zhu, Qingqing;Li, Lingxiangyu;Liao, Chunyang;Jiang, Guibin published 《COVID-19 Pandemic Impacts on Humans Taking Antibiotics in China》 in 2022. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Computed Properties of C10H9ClN4O2S The article mentions the following:

The outbreak of the novel coronavirus 2019 (COVID-19) pandemic has resulted in the increased human consumption of medicines. Antibiotics are of great concern due to their adverse effects, such as increased bacterial resistance and dysbiosis of gut microbiota. Nevertheless, very little is known about the changes in self-medication with antibiotics during the COVID-19 pandemic and the resultant potential health risks. Herein, we examined the concentration profiles of some commonly used antibiotics in human urine collected from several geog. regions in China between 2020 and 2021. Antibiotics were found in 99.2% of the urine samples at concentrations ranging from not detected (nd) to 357 000 (median: 10.2) ng/mL. During the COVID-19 pandemic, concentrations of urinary antibiotics were remarkably higher than those found either before the pandemic or in the smooth period of the pandemic. Moreover, elevated levels of antibiotics were determined in urine samples from the regions with more confirmed cases. The exposure assessment showed that hazard index values >1 were determined in 35.2% of people. These findings show that human exposure to antibiotics increased during the COVID-19 pandemic, and further research is imperative to identify the public health risks. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Computed Properties of C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dong, Jianwei;Shang, Meiqi;Feng, Ranran;Song, Xin;Yan, Dandan;Xie, Hui published 《Export and risk from antibiotic remobilization from surrounding water to lake in the extreme 2020 Yangtze River basin flooding》. The research results were published in《Science of the Total Environment》 in 2022.Recommanded Product: 80-32-0 The article conveys some information:

Global climate change increased the frequency of extreme rainfall events, leading to higher flood risk. In addition to the personal and property losses, another important consequence of a flood disaster was release and exposure risks from emerging contaminants, which was usually overlooked. The remobilization and fate of the antibiotics induced by floods remain unclear. We captured antibiotic concentrations around the Chaohu Lake after an unprecedented flood with a range of 5.0-317 ng/L. Higher concentrations in polder waters than their receiving rivers were attributed to the antibiotic release from soil particles and the sharp increase of water: soil ratio by flood storage. Source apportionment anal. of antibiotics implied that diffuse pollution by manure application and aquaculture activity was the predominant sources. Commonalities of spatial variations of antibiotics in polders were related to the condition of waterlogging and pollution source. The total antibiotic storage for all submerged polders was estimated at 27.9 kg. The concentrations and risks from pumping floodwater detained by polders into the lake were much higher than that from discharging flood directly into the lake. The retention-reaction-remobilization process would pose unexpectedly high risks for the lake. This study provided a new sight for constructing ecol. wetland flood storage areas.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Recommanded Product: 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhou, Min;Hong, Bing;Li, Juan;Yu, Shen published 《Fingerprinting pharmaceuticals of multiple sources at a provincial watershed scale》 in 2022. The article was appeared in 《Science of the Total Environment》. They have made some progress in their research.Electric Literature of C10H9ClN4O2S The article mentions the following:

Pharmaceutical residues in the aquatic environment have increasingly attracted public concerns but their fingerprint of sources remain unclear at a watershed scale. This study systematically explored pharmaceutical residues in effluent of 8 different type of sources in a provincial watershed in China using a multi-category protocol of pharmaceutical quantification. Seventy-seven out of 94 target compounds from 6 categories were quantified in effluent, up to 71,318 ng L^-1 in total from urban hospital sources with 20 antibiotics and 32 others. The spectrum of the quantified compounds in effluent significantly differentiated the urban (hospitals, domestic sewages, and WWTPs), rural (health centers and domestic sewages), and agricultural production sources (poultry and swine breeding yards, aquaculture ponds, and paddy fields). Compounds of non-steroidal anti-inflammation drugs (NSAIDs), cardiovascular drugs (CVs), and central nervous drugs (CNs) could fingerprint the three groups of sources. However, the three categories contributed 7 out of 10 compounds with high risk (risk quotient >1.0) to the aquatic environment identified by the eco-environmental risk assessment. No high-risk compounds were identified in effluent of urban WWTPs. Findings of this study suggest source identification and compound spectrum fingerprinting are crucial for studies on pharmaceutical residues in the aquatic environment, especially the complexity of pharmaceutical residues in source effluents for exploring source-sink dynamics at a watershed scale. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Electric Literature of C10H9ClN4O2SDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bueno, Irene;Beaudoin, Amanda;Arnold, William A.;Kim, Taegyu;Frankson, Lara E.;LaPara, Timothy M.;Kanankege, Kaushi;Wammer, Kristine H.;Singer, Randall S. published 《Quantifying and predicting antimicrobials and antimicrobial resistance genes in waterbodies through a holistic approach: a study in Minnesota, United States》 in 2021. The article was appeared in 《Scientific Reports》. They have made some progress in their research.Product Details of 80-32-0 The article mentions the following:

The environment plays a key role in the spread and persistence of antimicrobial resistance (AMR). Antimicrobials and antimicrobial resistance genes (ARG) are released into the environment from sources such as wastewater treatment plants, and animal farms. This study describes an approach guided by spatial mapping to quantify and predict antimicrobials and ARG in Minnesota’s waterbodies in water and sediment at two spatial scales: macro, throughout the state, and micro, in specific waterbodies. At the macroscale, the highest concentrations across all antimicrobial classes were found near populated areas. Kernel interpolation provided an approximation of antimicrobial concentrations and ARG abundance at unsampled locations. However, there was high uncertainty in these predictions, due in part to low study power and large distances between sites. At the microscale, wastewater treatment plants had an effect on ARG abundance (sul1 and sul2 in water; blaSHV, intl1, mexB, and sul2 in sediment), but not on antimicrobial concentrations Results from sediment reflected a long-term history, while water reflected a more transient record of antimicrobials and ARG. This study highlights the value of using spatial analyses, different spatial scales, and sampling matrixes, to design an environmental monitoring approach to advance our understanding of AMR persistence and dissemination.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Product Details of 80-32-0 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yin, Fubin;Dong, Hongmin;Zhang, Wanqin;Wang, Shunli;Shang, Bin;Zhu, Zhiping published 《Ability of anaerobic digestion to remove antibiotics contained in swine manure》. The research results were published in《Biosystems Engineering》 in 2021.Related Products of 80-32-0 The article conveys some information:

Antibiotics in animal manure, which are used to treat animal diseases, have become a major concern due to human and ecol. health risks. Anaerobic digestion (AD) is viable for treating manure because it generates energy. However, the ability of AD to completely eliminate antibiotics remains unclear. Therefore, the AD ability of swine manure containing 10 antibiotics was investigated. The results showed that the thresholds of complete antibiotic reduction were 25, 50, 50, 75, 75, and 75 mg (kg TS)^-1 for SD, CIP, SQ, SAR, DIF, and SA, resp. At their thresholds, SD, CIP, and SA could increase methane production, but the opposite results were obtained for SQ, SAR, and DIF. The modified Gompertz model showed good application for AD with different antibiotic loads. Antibiotic reduction and methane production are strongly correlated for the antibiotics of SAR and ENR, so their reduction performance can be inferred simply by determining their methane production4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Related Products of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lei Lu, Tan;Shahriman, Mohamad Shariff;Sambasevam, Kavirajaa Pandian;Mohamad Zain, Nur Nadhirah;Yahaya, Noorfatimah;Lim, Vuanghao;Raoov, Muggundha published 《In-tip solid-phase microextraction: a method for determination of sulphonamide residues in environmental water samples》 in . The article was appeared in 《International Journal of Environmental Analytical Chemistry》. They have made some progress in their research.Category: pyridine-derivatives The article mentions the following:

This study involved the development of an in-pipet tip solid-phase microextraction (SPME) method using activated charcoal as an adsorbent. Simultaneous determination of three sulfonamide antibiotic residues in environmental water was performed using this method, coupled with high-performance liquid chromatog.-photodiode array (HPLC-PDA) detection. Seven extraction parameters were optimized by one-variable-at-a-time (OVAT) and response surface (RSM) methods. Optimum extraction efficiency was achieved when 10 mL of sample solution at a natural pH (pH 5-6) was loaded through a 1 mL pipet tip packed with 10 mg of adsorbent, washed with 1 mL of hexane and eluted with 500 μL of 1% ammonium in methanol solution Under the optimized exptl. condition, this method manifested good linearity (5-500 μg L^-1) at the coefficient of determination, R2 of 0.9992 to 0.9993, high sensitivity (limit of detection, LOD: 0.38-1.14 μg L^-1; limit of quantification, LOQ: 1.14-3.35 μg L^-1), and satisfactory recoveries (82.8-108.7%) with acceptable reproducibility (RSD < 4.6%). Real sample anal. of five environmental water samples sourced from Universiti Malaya, Kuala Lumpur and Malacca showed that the samples contained either none or traces of the target sulfonamides (SAs) with their concentration lower than the LOQs. In contrast to other methods, the comparison outcomes depicted that this in-tip SPME method was beneficial in terms of its simple, reusable, cost-saving setup together with a significant reduction in chem. consumption. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem